ENSGALG00000007625


Gallus gallus

Features
Gene ID: ENSGALG00000007625
  
Biological name :FADD
  
Synonyms : FADD / Fas associated via death domain
  
Possible biological names infered from orthology : FAS-associated death domain protein / Q13158 / Q61160
  
Species: Gallus gallus
  
Chr. number: 5
Strand: 1
Band:
Gene start: 17814653
Gene end: 17816686
  
Corresponding Affymetrix probe sets: Gga.10782.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000012326
NCBI entrez gene - 423146     See in Manteia.
RefSeq - XM_421073
swissprot - F1NKQ7
Ensembl - ENSGALG00000007625
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 faddENSDARG00000103021Danio rerio
 FADDENSG00000168040Homo sapiens
 FaddENSMUSG00000031077Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR001875  Death effector domain
 IPR011029  Death-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001916 positive regulation of T cell mediated cytotoxicity IEA
 biological_processGO:0002821 positive regulation of adaptive immune response IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0033077 T cell differentiation in thymus IEA
 biological_processGO:0036462 TRAIL-activated apoptotic signaling pathway IEA
 biological_processGO:0042104 positive regulation of activated T cell proliferation IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043029 T cell homeostasis IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045651 positive regulation of macrophage differentiation IEA
 biological_processGO:0045862 positive regulation of proteolysis IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048535 lymph node development IEA
 biological_processGO:0048536 spleen development IEA
 biological_processGO:0048538 thymus development IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway IEA
 biological_processGO:0060546 negative regulation of necroptotic process IEA
 biological_processGO:0070236 negative regulation of activation-induced cell death of T cells IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0097049 motor neuron apoptotic process IEA
 biological_processGO:0097190 apoptotic signaling pathway IEA
 biological_processGO:0097191 extrinsic apoptotic signaling pathway IEA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:0097202 activation of cysteine-type endopeptidase activity IEA
 biological_processGO:0097527 necroptotic signaling pathway IEA
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:2000454 positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0031264 death-inducing signaling complex IEA
 cellular_componentGO:0031265 CD95 death-inducing signaling complex IEA
 cellular_componentGO:0097342 ripoptosome IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0032813 tumor necrosis factor receptor superfamily binding IEA
 molecular_functionGO:0035877 death effector domain binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0089720 caspase binding IEA


Pathways (from Reactome)
Pathway description
via Death Receptors in the presence of ligand
TRIF-mediated programmed cell death
Regulation by c-FLIP
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Dimerization of procaspase-8
FasL/ CD95L signaling
TRAIL signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008240 CFLAR / CASP8 and FADD-like apoptosis regulator / O15519* / O35732* / CASP8 and FADD-like apoptosis regulator CASP8 and FADD-like apoptosis regulator subunit p43 CASP8 and FADD-like apopto...  / reaction / complex
 ENSGALG00000003076 FASLG / Fas ligand / Fasl* / P41047* / P48023* / Tumor necrosis factor ligand superfamily member 6 Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor lig...  / reaction / complex
 ENSGALG00000000452 TNFRSF10B / O14798* / Q9UBN6* / O00220* / O14763* / Q9QZM4* / TNFRSF10D* / TNFRSF10A* / TNFRSF10C* / TNF receptor superfamily member 10b* / TNF receptor superfamily member 10a* / TNF recept...  / reaction / complex
 ENSGALG00000007625 FADD / Fas associated via death domain / Q13158* / Q61160* / FAS-associated death domain protein *  / reaction / complex
 ENSGALG00000009179 TNFSF10 / TNF superfamily member 10 / P50591* / P50592* / tumor necrosis factor (ligand) superfamily, member 10*  / complex / reaction
 ENSGALG00000012827 RIPK1 / receptor interacting serine/threonine kinase 1 / Q13546* / Q60855* / Receptor-interacting serine/threonine-protein kinase 1 *  / complex / reaction
 ENSGALG00000006351 FAS / Fas cell surface death receptor / P25445* / P25446* / Tumor necrosis factor receptor superfamily member 6 *  / reaction / complex
 ENSGALG00000026850 TICAM1 / TIR domain-containing adapter molecule 1 / Q80UF7* / Q8IUC6* / toll like receptor adaptor molecule 1*  / complex / reaction
 ENSGALG00000039140 CD14 / monocyte differentiation antigen CD14 precursor / P10810* / P08571* / CD14 molecule* / Monocyte differentiation antigen CD14 *  / reaction / complex
 ENSGALG00000032701 LY96 / lymphocyte antigen 96 / Q9JHF9* / Q9Y6Y9*  / complex / reaction






 

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