HP:0000006 | Autosomal dominant inheritance | "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators] |
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HP:0000083 | Renal failure | |
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HP:0000155 | Oral ulcers | |
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HP:0000407 | Hearing loss, sensorineural | "Hearing loss caused by damage or dysfunction of the auditory nerve (cranial nerve VIII)." [HPO:curators] |
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HP:0000488 | Retinopathy | |
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HP:0000499 | Abnormality of the eyelashes | "An abnormality of the `eyelashes` (FMA:53669)." [HPO:probinson] |
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HP:0000501 | Glaucoma | "Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usually associated with increased intraocular pressure." [HPO:curators] |
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HP:0000505 | Impaired vision | |
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HP:0000518 | Cataract | "A cataract is an opacity or clouding that develops in the crystalline `lens` (FMA:58241) of the eye or in its `capsule` (FMA:58881)." [HPO:probinson] |
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HP:0000534 | Abnormality of the eyebrow | "An abnormality of the `eyebrow` (FMA:54237)." [HPO:probinson] |
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HP:0000541 | Detached retina | |
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HP:0000613 | Photophobia | "Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light." [HPO:curators] |
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HP:0000618 | Blindness | |
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HP:0000737 | Irritability | |
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HP:0001025 | Urticaria | |
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HP:0001045 | Vitiligo | |
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HP:0001053 | Hypopigmented skin patches | |
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HP:0001061 | Acne | |
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HP:0001097 | Keratoconjunctivitis sicca | "Dryness of the eye related to deficiency of the tear film components (aqueous, mucin, or lipid), lid surface abnormalities, or epithelial abnormalities. Keratoconjunctivitis sicca often results in a scratchy or sandy sensation (foreign body sensation) in the eyes, and may also be associated with itching, inability to produce tears, photosensitivity, redness, pain, and difficulty in moving the eyelids." [HPO:curators] |
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HP:0001250 | Seizures | "Seizures are an intermittent `abnormality of the central nervous system` (FMA:HP:0002011) due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements." [HPO:probinson] |
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HP:0001251 | Ataxia | "Ataxia is a nonspecific neurological sign and symptom consisting of gross lack of coordination of muscle movements. Ataxia is caused by dysfunction of one or more parts of the nervous system including the cerebellum, the sensory nervous system, the vestibular system, or the cerebral cortex." [HPO:curators] |
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HP:0001269 | Hemiparesis | "Relatively mild weakness in the arm, leg, and in some cases the face on one side of the body." [HPO:curators] |
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HP:0001287 | Meningitis | |
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HP:0001288 | Gait disturbance | "The term gait disturbance can refer to any disruption of the ability to walk. In general, this can refer to neurological diseases but also fractures or other sources of pain that is triggered upon walking. However, in the current context gait disturbance refers to difficulty walking on the basis of a neurological or muscular disease." [HPO:curators] |
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HP:0001289 | Confusion | "Lack of clarity and coherence of thought, perception, understanding, or action." [HPO:curators] |
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HP:0001347 | Hyperreflexia | "The presence of overactive or overresponsive reflexes." [HPO:curators] |
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HP:0001369 | Arthritis | |
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HP:0001482 | Subcutaneous nodules | |
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HP:0001637 | Abnormality of the myocardium | |
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HP:0001653 | Mitral regurgitation | "An `abnormality of the mitral valve` (HP:0001633) characterized by insufficiency or incompetence of the mitral valve resulting in retrograde leaking of blood through the mitral valve upon ventricular contraction." [HPO:probinson] |
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HP:0001658 | Myocardial infarction | |
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HP:0001659 | Aortic insufficiency | "An insufficiency of the aortic valve, leading to regurgitation (backward flow) of blood from the aorta into the left ventricle." [HPO:curators] |
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HP:0001701 | Pericarditis | |
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HP:0001733 | Pancreatitis | |
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HP:0001744 | Splenomegaly | "An abnormal enlargement of the spleen." [HPO:curators] |
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HP:0001824 | Weight loss | |
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HP:0001880 | Eosinophilia | "Increased count of eosinophile granulocytes in the blood." [HPO:sdoelken] |
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HP:0001890 | Autoimmune hemolytic anemia | |
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HP:0001891 | Iron deficiency anemia | |
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HP:0001904 | Autoimmune neutropenia | |
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HP:0001945 | Fever | |
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HP:0001973 | Immune thrombocytopenia | |
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HP:0002017 | Nausea and vomiting | |
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HP:0002024 | Malabsorption | |
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HP:0002027 | Abdominal pain | |
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HP:0002039 | Anorexia | |
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HP:0002076 | Migraine | |
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HP:0002102 | Pleuritis | "Inflammation of the pleura." [HPO:sdoelken] |
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HP:0002105 | Hemoptysis | "Coughing up (expectoration) of blood or blood-streaked sputum from the larynx, trachea, bronchi, or lungs." [HPO:curators] |
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HP:0002113 | Pulmonary infiltrates | |
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HP:0002202 | Pleural effusion | "The presence of an excessive amount of fluid in the pleural cavity." [HPO:curators] |
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HP:0002204 | Pulmonary embolism | |
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HP:0002209 | Sparse scalp hair | "Sparseness of the `head hair` (FMA:54241)." [HPO:probinson] |
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HP:0002216 | Premature graying of hair | |
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HP:0002239 | Gastrointestinal hemorrhage | |
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HP:0002240 | Hepatomegaly | "An abnormal enlargment of the liver." [HPO:curators] |
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HP:0002290 | Poliosis | "Circumscribed depigmentation of the hair of the head or the eyelashes." [HPO:curators] |
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HP:0002321 | Vertigo | "An abnormal sensation of spinning while the body is actually stationary." [HPO:curators] |
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HP:0002354 | Memory impairment | |
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HP:0002376 | Developmental regression | |
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HP:0002383 | Encephalitis | |
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HP:0002516 | Increased intracranial pressure | |
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HP:0002633 | Vasculitis | |
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HP:0002637 | Cerebral ischemia | |
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HP:0002716 | Lymphadenopathy | |
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HP:0002729 | Lymph nodes show florid reactive follicular hyperplasia and marked paracortical expansion with immunoblasts and plasma cells | |
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HP:0002730 | Chronic noninfectious lymphadenopathy | |
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HP:0002731 | Defective lymphocyte apoptosis | |
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HP:0002829 | Arthralgia | |
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HP:0002851 | Increased number of CD4-/CD8- T cells expressing alpha/beta T-cell receptors | |
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HP:0002853 | Increased proportion of HLA DR+ and CD57+ T cells | |
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HP:0002923 | Rheumatoid factor positive | |
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HP:0002972 | Reduced delayed hypersensitivity | |
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HP:0003237 | Increased IgG level | "An abnormally increased level of immunoglobulin G in blood." [HPO:probinson] |
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HP:0003261 | Increased IgA level | "An abnormally increased level of immunoglobulin A in blood." [HPO:probinson] |
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HP:0003262 | Smooth muscle antibody positive | |
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HP:0003326 | Myalgia | "A tendency to experience muscle pain." [HPO:curators] |
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HP:0003401 | Paresthesia | "Abnormal sensations such as tingling, pricking, or numbness of the skin with no apparent physical cause." [HPO:curators] |
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HP:0003453 | Neutrophil antibody positive | |
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HP:0003454 | Platelet antibody positive | |
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HP:0003493 | Antinuclear antibody positive | |
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HP:0003496 | Increased IgM level | "An abnormally increased level of immunoglobulin M in blood." [HPO:probinson] |
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HP:0003613 | Phospholipid antibody positive | |
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HP:0004322 | Decreased body height | "A height below that which is expected according to age and gender norms. Although there is no universally accepted definition of short stature, many refer to "short stature" as height more than 2 standard deviations below the mean for age and gender (or below the 3rd percentile for age and gender dependent norms)." [HPO:curators] |
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HP:0004420 | Arterial thrombosis | |
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HP:0004844 | coombs-positive hemolytic anemia | |
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HP:0004936 | Venous thrombosis | |
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HP:0006824 | Cranial nerve paralysis | |
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HP:0007256 | Mild pyramidal signs | |
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HP:0008066 | Abnormal blistering of the skin | |
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HP:0010885 | Aseptic necrosis | "A disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply." [HPO:sdoelken] |
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HP:0011107 | Recurrent aphthous stomatitis | "Recurrent episodes of ulceration of the oral mucosa." [HPO:probinson] |
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HP:0012378 | Fatigue | "A subjective feeling of tiredness characterized by a lack of energy and motivation." [HPO:probinson] |
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HP:0100326 | Immunologic hypersensitivity | |
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HP:0100543 | Cognitive impairment | "Abnormality in the process of thought including the ability to process information." [HPO:sdoelken] |
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HP:0100584 | Endocarditis | "An inflammation of the endocardium, the inner layer of the heart, which usually involves the heart valves." [HPO:sdoelken] |
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HP:0100614 | Myositis | "A general term for inflammation of the muscles without respect to the underlying cause." [HPO:sdoelken] |
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HP:0100654 | Retrobulbar optic neuritis | "`Optic neuritis`(HP:0100653) that occurs in the section of the optic nerve located behind the eyebal." [HPO:sdoelken] |
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HP:0100758 | Gangrene | "A serious and potentially life-threatening condition that arises when a considerable mass of body tissue dies (necrosis)." [ISBN:9780781770873] |
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HP:0100796 | Orchitis | "Testicular inflammation." [HPO:sdoelken] |
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HP:0100820 | Glomerulopathy | "Inflammatory or noninflammatory diseases affecting the glomeruli of the nephron." [HPO:sdoelken] |
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HP:0200034 | skin papules | "A circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point." [HPO:SKOEHLER] |
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