ENSG00000158856


Homo sapiens

Features
Gene ID: ENSG00000158856
  
Biological name :DMTN
  
Synonyms : dematin actin binding protein / DMTN / Q08495
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p21.3
Gene start: 22048995
Gene end: 22082527
  
Corresponding Affymetrix probe sets: 204505_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000429234
Ensembl peptide - ENSP00000429116
Ensembl peptide - ENSP00000429377
Ensembl peptide - ENSP00000478536
Ensembl peptide - ENSP00000477684
Ensembl peptide - ENSP00000430618
Ensembl peptide - ENSP00000430609
Ensembl peptide - ENSP00000430600
Ensembl peptide - ENSP00000430382
Ensembl peptide - ENSP00000429948
Ensembl peptide - ENSP00000265800
Ensembl peptide - ENSP00000350977
Ensembl peptide - ENSP00000370879
Ensembl peptide - ENSP00000397904
Ensembl peptide - ENSP00000401291
Ensembl peptide - ENSP00000416111
Ensembl peptide - ENSP00000427866
Ensembl peptide - ENSP00000428063
Ensembl peptide - ENSP00000428415
Ensembl peptide - ENSP00000428733
NCBI entrez gene - 2039     See in Manteia.
OMIM - 125305
RefSeq - XM_017013198
RefSeq - NM_001114138
RefSeq - NM_001114139
RefSeq - NM_001302816
RefSeq - NM_001302817
RefSeq - NM_001323378
RefSeq - NM_001323380
RefSeq - NM_001323381
RefSeq - NM_001323382
RefSeq - NM_001323383
RefSeq - NM_001323384
RefSeq - NM_001323385
RefSeq - NM_001323387
RefSeq - NM_001323388
RefSeq - NM_001323389
RefSeq - NM_001323390
RefSeq - NM_001323391
RefSeq - NM_001323392
RefSeq - NM_001323393
RefSeq - NM_001323394
RefSeq - NM_001323395
RefSeq - NM_001323396
RefSeq - NM_001323397
RefSeq - NM_001323398
RefSeq - NM_001323399
RefSeq - NM_001323400
RefSeq - NM_001323401
RefSeq - NM_001978
RefSeq - XM_005273432
RefSeq - XM_005273433
RefSeq - XM_005273442
RefSeq - XM_011544435
RefSeq - XM_017013189
RefSeq - XM_017013190
RefSeq - XM_017013191
RefSeq - XM_017013192
RefSeq - XM_017013193
RefSeq - XM_017013194
RefSeq - XM_017013195
RefSeq - XM_017013196
RefSeq - XM_017013197
RefSeq - NM_001114135
RefSeq - NM_001114136
RefSeq - NM_001114137
RefSeq Peptide - NP_001107609
RefSeq Peptide - NP_001310325
RefSeq Peptide - NP_001310326
RefSeq Peptide - NP_001310327
RefSeq Peptide - NP_001310328
RefSeq Peptide - NP_001310329
RefSeq Peptide - NP_001310330
RefSeq Peptide - NP_001969
RefSeq Peptide - NP_001107607
RefSeq Peptide - NP_001107608
RefSeq Peptide - NP_001107610
RefSeq Peptide - NP_001107611
RefSeq Peptide - NP_001289745
RefSeq Peptide - NP_001289746
RefSeq Peptide - NP_001310307
RefSeq Peptide - NP_001310308
RefSeq Peptide - NP_001310309
RefSeq Peptide - NP_001310310
RefSeq Peptide - NP_001310311
RefSeq Peptide - NP_001310312
RefSeq Peptide - NP_001310313
RefSeq Peptide - NP_001310314
RefSeq Peptide - NP_001310316
RefSeq Peptide - NP_001310317
RefSeq Peptide - NP_001310318
RefSeq Peptide - NP_001310319
RefSeq Peptide - NP_001310320
RefSeq Peptide - NP_001310321
RefSeq Peptide - NP_001310322
RefSeq Peptide - NP_001310323
RefSeq Peptide - NP_001310324
swissprot - E5RJ61
swissprot - E5RGQ7
swissprot - E5RGQ0
swissprot - E5RFK6
swissprot - E5RFK4
swissprot - A0A087WUC0
swissprot - E5RJC0
swissprot - Q08495
swissprot - A0A087WT94
Ensembl - ENSG00000158856
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX465198.3ENSDARG00000116484Danio rerio
 dmtnENSDARG00000013110Danio rerio
 DmtnENSMUSG00000022099Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ABLIM1 / O14639 / actin binding LIM protein 1ENSG0000009920445
ABLIM3 / O94929 / actin binding LIM protein family member 3ENSG0000017321035
ABLIM2 / Q6H8Q1 / actin binding LIM protein family member 2ENSG0000016399531
WTIP / A6NIX2 / WT1 interacting proteinENSG000001422796
LIMD1 / Q9UGP4 / LIM domains containing 1ENSG000001447916
LPP / Q93052 / LIM domain containing preferred translocation partner in lipomaENSG000001450125
TRIP6 / Q15654 / thyroid hormone receptor interactor 6ENSG000000870775
AJUBA / Q96IF1 / ajuba LIM proteinENSG000001294745
ZYX / zyxin / Q15942ENSG000001598405
FBLIM1 / Q8WUP2 / filamin binding LIM protein 1ENSG000001624581


Protein motifs (from Interpro)
Interpro ID Name
 IPR003128  Villin headpiece
 IPR032402  Putative adherens-junction anchoring domain
 IPR036886  Villin headpiece domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization TAS
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0010591 regulation of lamellipodium assembly IMP
 biological_processGO:0010763 positive regulation of fibroblast migration ISS
 biological_processGO:0010801 negative regulation of peptidyl-threonine phosphorylation ISS
 biological_processGO:0010812 negative regulation of cell-substrate adhesion ISS
 biological_processGO:0030036 actin cytoskeleton organization ISS
 biological_processGO:0030194 positive regulation of blood coagulation ISS
 biological_processGO:0032956 regulation of actin cytoskeleton organization IDA
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation ISS
 biological_processGO:0035584 calcium-mediated signaling using intracellular calcium source ISS
 biological_processGO:0035585 calcium-mediated signaling using extracellular calcium source ISS
 biological_processGO:0048821 erythrocyte development ISS
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation ISS
 biological_processGO:0051017 actin filament bundle assembly TAS
 biological_processGO:0051489 regulation of filopodium assembly IMP
 biological_processGO:0051693 actin filament capping IEA
 biological_processGO:0051895 negative regulation of focal adhesion assembly ISS
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:0065003 protein-containing complex assembly ISS
 biological_processGO:0070560 protein secretion by platelet ISS
 biological_processGO:0071277 cellular response to calcium ion ISS
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:0090303 positive regulation of wound healing ISS
 biological_processGO:0090315 negative regulation of protein targeting to membrane ISS
 biological_processGO:0090527 actin filament reorganization ISS
 biological_processGO:1900025 negative regulation of substrate adhesion-dependent cell spreading ISS
 biological_processGO:1900026 positive regulation of substrate adhesion-dependent cell spreading ISS
 biological_processGO:1901731 positive regulation of platelet aggregation ISS
 biological_processGO:2001046 positive regulation of integrin-mediated signaling pathway ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005884 actin filament IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0014731 spectrin-associated cytoskeleton IDA
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030863 cortical cytoskeleton IEA
 cellular_componentGO:0031095 platelet dense tubular network membrane IDA
 cellular_componentGO:0031253 cell projection membrane ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0005102 signaling receptor binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030507 spectrin binding IDA
 molecular_functionGO:0043621 protein self-association IEA


Pathways (from Reactome)
Pathway description
Miscellaneous transport and binding events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000075340 ADD2 / P35612 / adducin 2  / reaction / complex
 ENSG00000087274 ADD1 / P35611 / adducin 1  / complex / reaction
 ENSG00000148700 ADD3 / Q9UEY8 / adducin 3  / complex / reaction






 

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