ENSG00000269858


Homo sapiens

Features
Gene ID: ENSG00000269858
  
Biological name :EGLN2
  
Synonyms : egl-9 family hypoxia inducible factor 2 / EGLN2 / Q96KS0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.2
Gene start: 40798996
Gene end: 40808433
  
Corresponding Affymetrix probe sets: 220956_s_at (Human Genome U133 Plus 2.0 Array)   223083_s_at (Human Genome U133 Plus 2.0 Array)   227147_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472146
Ensembl peptide - ENSP00000472991
Ensembl peptide - ENSP00000472870
Ensembl peptide - ENSP00000472414
Ensembl peptide - ENSP00000307080
Ensembl peptide - ENSP00000385253
Ensembl peptide - ENSP00000469272
Ensembl peptide - ENSP00000469323
Ensembl peptide - ENSP00000469686
Ensembl peptide - ENSP00000470968
Ensembl peptide - ENSP00000471546
Ensembl peptide - ENSP00000471568
Ensembl peptide - ENSP00000471740
Ensembl peptide - ENSP00000471944
NCBI entrez gene - 112398     See in Manteia.
OMIM - 606424
RefSeq - NM_053046
RefSeq - NM_080732
RefSeq Peptide - NP_444274
RefSeq Peptide - NP_542770
swissprot - M0R0Z6
swissprot - M0R110
swissprot - M0R1A3
swissprot - M0R1L0
swissprot - M0R1W4
swissprot - M0R2X9
swissprot - M0R350
swissprot - A0A0C4DGR4
swissprot - Q96KS0
swissprot - A0A024R0R2
swissprot - M0QXM8
swissprot - M0QXR0
swissprot - M0R035
Ensembl - ENSG00000269858
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 egln2ENSDARG00000062562Danio rerio
 Egln2ENSMUSG00000058709Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EGLN1 / Q9GZT9 / egl-9 family hypoxia inducible factor 1ENSG0000013576641
EGLN3 / Q9H6Z9 / egl-9 family hypoxia inducible factor 3ENSG0000012952131
AC008537.1ENSG0000026879711


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth NAS
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline IDA
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway NAS
 biological_processGO:0043523 regulation of neuron apoptotic process IMP
 biological_processGO:0045454 cell redox homeostasis IDA
 biological_processGO:0045732 positive regulation of protein catabolic process IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008198 ferrous iron binding NAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IDA
 molecular_functionGO:0019826 oxygen sensor activity IDA
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0031545 peptidyl-proline 4-dioxygenase activity EXP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000116016 EPAS1 / Q99814 / endothelial PAS domain protein 1  / reaction
 ENSG00000100644 HIF1A / Q16665 / hypoxia inducible factor 1 alpha subunit  / reaction
 ENSG00000124440 HIF3A / Q9Y2N7 / hypoxia inducible factor 3 alpha subunit  / reaction






 

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