ENSMUSG00000058709


Mus musculus

Features
Gene ID: ENSMUSG00000058709
  
Biological name :Egln2
  
Synonyms : Egln2 / Egl nine homolog 2 / Q91YE2
  
Possible biological names infered from orthology : egl-9 family hypoxia inducible factor 2 / Q96KS0
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: A3
Gene start: 27158658
Gene end: 27166802
  
Corresponding Affymetrix probe sets: 10561170 (MoGene1.0st)   1416533_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000078966
Ensembl peptide - ENSMUSP00000104019
NCBI entrez gene - 112406     See in Manteia.
MGI - MGI:1932287
RefSeq - XM_017321929
RefSeq - NM_053208
RefSeq Peptide - NP_444438
swissprot - Q80X29
swissprot - Q91YE2
Ensembl - ENSMUSG00000058709
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 egln2ENSDARG00000062562Danio rerio
 EGLN2ENSG00000269858Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Egln1 / Q91YE3 / Egl nine homolog 1 / Q9GZT9* / egl-9 family hypoxia inducible factor 1*ENSMUSG0000003198740
Egln3 / egl-9 family hypoxia inducible factor 3 / Q9H6Z9*ENSMUSG0000003510531


Protein motifs (from Interpro)
Interpro ID Name
 IPR005123  Oxoglutarate/iron-dependent dioxygenase
 IPR006620  Prolyl 4-hydroxylase, alpha subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia ISS
 biological_processGO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline ISO
 biological_processGO:0043523 regulation of neuron apoptotic process ISO
 biological_processGO:0045454 cell redox homeostasis ISS
 biological_processGO:0045732 positive regulation of protein catabolic process ISS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors ISO
 molecular_functionGO:0019826 oxygen sensor activity ISO
 molecular_functionGO:0031418 L-ascorbic acid binding IEA
 molecular_functionGO:0031545 peptidyl-proline 4-dioxygenase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051213 dioxygenase activity IEA


Pathways (from Reactome)
Pathway description
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000443 abnormal snout morphology "anomalous structure or development of the anterior facial part of the muzzle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001190 reddish skin "skin has a more intense ruddy appearance than normal, often due to capillary congestion" [J:65038]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Plcg2tm1Kuro/Plcg2tm1Kuro,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Egln2tm2Fong/Egln2tm2Fong,Egln3tm2Fong/Egln3tm2Fong,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NCr * CD-1

 MP:0002872 polycythemia "an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003852 skeletal muscle necrosis "pathological cell death in the skeletal muscle, usually due to irreversible damage" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Plcg2tm1Kuro/Plcg2tm1Kuro,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Plcg2tm1Kuro/Plcg2tm1Kuro,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Plcg2tm1Kuro/Plcg2tm1Kuro,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008826 abnormal splenic cell ratio "deviation from the standard ratios of splenocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Egln1tm2Fong/Egln1tm2Fong,Gt(ROSA)26Sortm1(cre/ERT2)Alj/Gt(ROSA)26Sor+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021109 Hif1a / Q61221 / Hypoxia-inducible factor 1-alpha / Q16665* / hypoxia inducible factor 1 alpha subunit*  / reaction
 ENSMUSG00000004328 Hif3a / Q0VBL6 / Hypoxia-inducible factor 3-alpha / Q9Y2N7* / hypoxia inducible factor 3 alpha subunit*  / reaction






 

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