ENSG00000185651


Homo sapiens

Features
Gene ID: ENSG00000185651
  
Biological name :UBE2L3
  
Synonyms : P68036 / UBE2L3 / ubiquitin conjugating enzyme E2 L3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q11.21
Gene start: 21549447
Gene end: 21624034
  
Corresponding Affymetrix probe sets: 200676_s_at (Human Genome U133 Plus 2.0 Array)   200682_s_at (Human Genome U133 Plus 2.0 Array)   200683_s_at (Human Genome U133 Plus 2.0 Array)   200684_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000445931
Ensembl peptide - ENSP00000344259
Ensembl peptide - ENSP00000400906
NCBI entrez gene - 7332     See in Manteia.
OMIM - 603721
RefSeq - NM_001256355
RefSeq - NM_001256356
RefSeq - NM_003347
RefSeq Peptide - NP_001243284
RefSeq Peptide - NP_001243285
RefSeq Peptide - NP_003338
swissprot - P68036
swissprot - A0A024R1A4
Ensembl - ENSG00000185651
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube2l3aENSDARG00000112087Danio rerio
 ube2l3bENSDARG00000027141Danio rerio


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
UBE2L5 / ubiquitin conjugating enzyme E2 L5ENSG0000023644468
O14933 / UBE2L6 / ubiquitin conjugating enzyme E2 L6ENSG0000015658738
P62837 / UBE2D2 / ubiquitin conjugating enzyme E2 D2ENSG0000013150827
Q9Y2X8 / UBE2D4 / ubiquitin conjugating enzyme E2 D4 (putative)ENSG0000007896727
P51668 / UBE2D1 / ubiquitin conjugating enzyme E2 D1ENSG0000007240126
P61077 / UBE2D3 / ubiquitin conjugating enzyme E2 D3ENSG0000010933225
Q969T4 / UBE2E3 / ubiquitin conjugating enzyme E2 E3ENSG0000017003524
Q96LR5 / UBE2E2 / ubiquitin conjugating enzyme E2 E2ENSG0000018224724
P51965 / UBE2E1 / ubiquitin conjugating enzyme E2 E1ENSG0000017014224
UBE2S / Q16763 / ubiquitin conjugating enzyme E2 SENSG0000010810618


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like
 IPR023313  Ubiquitin-conjugating enzyme, active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006464 cellular protein modification process TAS
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process TAS
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0031398 positive regulation of protein ubiquitination IGI
 biological_processGO:0044770 cell cycle phase transition IMP
 biological_processGO:0051443 positive regulation of ubiquitin-protein transferase activity IGI
 biological_processGO:0070979 protein K11-linked ubiquitination IDA
 biological_processGO:0071383 cellular response to steroid hormone stimulus IMP
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IDA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IMP
 cellular_componentGO:0000151 ubiquitin ligase complex TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding TAS
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0061631 ubiquitin conjugating enzyme activity IDA
 molecular_functionGO:0097027 ubiquitin-protein transferase activator activity IGI


Pathways (from Reactome)
Pathway description
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000151692 P50876 / RNF144A / ring finger protein 144A  / reaction / complex
 ENSG00000253729 PRKDC / P78527 / protein kinase, DNA-activated, catalytic polypeptide  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr