ENSG00000138642


Homo sapiens

Features
Gene ID: ENSG00000138642
  
Biological name :HERC6
  
Synonyms : HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 / HERC6 / Q8IVU3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: 1
Band: q22.1
Gene start: 88378739
Gene end: 88443111
  
Corresponding Affymetrix probe sets: 1563659_at (Human Genome U133 Plus 2.0 Array)   219352_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000425504
Ensembl peptide - ENSP00000273960
Ensembl peptide - ENSP00000369617
Ensembl peptide - ENSP00000425060
Ensembl peptide - ENSP00000264346
NCBI entrez gene - 55008     See in Manteia.
OMIM - 609249
RefSeq - XM_017008333
RefSeq - NM_001165136
RefSeq - NM_017912
RefSeq - XM_005263083
RefSeq - XM_011532053
RefSeq Peptide - NP_001158608
RefSeq Peptide - NP_060382
swissprot - D6RCT4
swissprot - H0Y9U0
swissprot - Q8IVU3
swissprot - A0A0B4J1R3
Ensembl - ENSG00000138642
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HERC5ENSDARG00000075785Danio rerio
 ENSGALG00000042001Gallus gallus
 Herc6ENSMUSG00000029798Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5ENSG0000013864649
HERC3 / Q15034 / HECT and RLD domain containing E3 ubiquitin protein ligase 3ENSG0000013864138
HERC4 / Q5GLZ8 / HECT and RLD domain containing E3 ubiquitin protein ligase 4ENSG0000014863437
HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2ENSG0000012873120
HERC1 / Q15751 / HECT and RLD domain containing E3 ubiquitin protein ligase family member 1ENSG0000010365718
UBE3A / Q05086 / ubiquitin protein ligase E3AENSG0000011406218
HECTD3 / Q5T447 / HECT domain E3 ubiquitin protein ligase 3ENSG0000012610715
HECTD2 / Q5U5R9 / HECT domain E3 ubiquitin protein ligase 2ENSG0000016533815
RCCD1 / A6NED2 / RCC1 domain containing 1ENSG000001669658
AC098582.1ENSG000002853852


Protein motifs (from Interpro)
Interpro ID Name
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR000569  HECT domain
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
 IPR035983  HECT, E3 ligase catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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