Manteia

ENSMUSG00000029798

Mus musculus

Features

Gene ID:	ENSMUSG00000029798

Biological name :	Herc6

Synonyms :	E3 ISG15--protein ligase Herc6 / F2Z461 / Herc6

Possible biological names infered from orthology :	HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 / Q8IVU3

Species:	Mus musculus

Chr. number:	6
Strand:	1
Band:	B3
Gene start:	57581000
Gene end:	57664632

Corresponding Affymetrix probe sets:	10538590 (MoGene1.0st) 1427813_at (Mouse Genome 430 2.0 Array) 1431095_a_at (Mouse Genome 430 2.0 Array) 1432026_a_at (Mouse Genome 430 2.0 Array) 1438037_at (Mouse Genome 430 2.0 Array) 1453757_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000031817 Ensembl peptide - ENSMUSP00000145505 NCBI entrez gene - 67138 See in Manteia. MGI - MGI:1914388 RefSeq - NM_025992 RefSeq Peptide - NP_080268 swissprot - F2Z461 swissprot - A0A0N4SWG1 Ensembl - ENSMUSG00000029798

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Herc3 / HECT and RLD domain containing E3 ubiquitin protein ligase 3 / Q15034*	ENSMUSG00000029804	37
Herc4 / Q6PAV2 / Probable E3 ubiquitin-protein ligase HERC4 / Q5GLZ8* / HECT and RLD domain containing E3 ubiquitin protein ligase 4*	ENSMUSG00000020064	35
Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*	ENSMUSG00000030451	19
Herc1 / HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 / Q15751*	ENSMUSG00000038664	18
Ube3a / O08759 / ubiquitin protein ligase E3A / Q05086*	ENSMUSG00000025326	17
Hectd2 / Q8CDU6 / Probable E3 ubiquitin-protein ligase HECTD2 / Q5U5R9* / HECT domain E3 ubiquitin protein ligase 2*	ENSMUSG00000041180	17
Hectd3 / Q3U487 / E3 ubiquitin-protein ligase HECTD3 / Q5T447* / HECT domain E3 ubiquitin protein ligase 3*	ENSMUSG00000046861	13
Rccd1 / Q8BTU7 / RCC1 domain-containing protein 1 / A6NED2* / RCC1 domain containing 1*	ENSMUSG00000038930	7

Protein motifs (from Interpro)

Interpro ID	Name
IPR000408	Regulator of chromosome condensation, RCC1
IPR000569	HECT domain
IPR009091	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
IPR035983	HECT, E3 ligase catalytic domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002244	hematopoietic progenitor cell differentiation	IGI
biological_process	GO:0002376	immune system process	IEA
biological_process	GO:0016567	protein ubiquitination	ISO
biological_process	GO:0045087	innate immune response	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IBA
cellular_component	GO:0005829	cytosol	IEA
molecular_function	GO:0004842	ubiquitin-protein transferase activity	ISO
molecular_function	GO:0016740	transferase activity	IEA
molecular_function	GO:0030332	cyclin binding	ISO
molecular_function	GO:0061630	ubiquitin protein ligase activity	ISO

Pathways (from Reactome)

Pathway description

Antigen processing: Ubiquitination & Proteasome degradation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0002644	decreased circulating triglyceride level	"lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Grin2b^{tm1e.1(KOMP)Wtsi}/Grin2b⁺ Genetic Background: C57BL/6N-Grin2b^{tm1e.1(KOMP)Wtsi}/Tcp

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr