ENSMUSG00000025326


Mus musculus

Features
Gene ID: ENSMUSG00000025326
  
Biological name :Ube3a
  
Synonyms : O08759 / Ube3a / ubiquitin protein ligase E3A
  
Possible biological names infered from orthology : Q05086
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: B5
Gene start: 59228750
Gene end: 59311536
  
Corresponding Affymetrix probe sets: 10553813 (MoGene1.0st)   1416680_at (Mouse Genome 430 2.0 Array)   1416681_at (Mouse Genome 430 2.0 Array)   1416682_at (Mouse Genome 430 2.0 Array)   1425206_a_at (Mouse Genome 430 2.0 Array)   1431224_at (Mouse Genome 430 2.0 Array)   1437354_at (Mouse Genome 430 2.0 Array)   1438695_at (Mouse Genome 430 2.0 Array)   1445727_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143896
Ensembl peptide - ENSMUSP00000146673
Ensembl peptide - ENSMUSP00000146524
Ensembl peptide - ENSMUSP00000144645
Ensembl peptide - ENSMUSP00000144453
Ensembl peptide - ENSMUSP00000144398
Ensembl peptide - ENSMUSP00000144220
Ensembl peptide - ENSMUSP00000144148
Ensembl peptide - ENSMUSP00000143962
Ensembl peptide - ENSMUSP00000103161
Ensembl peptide - ENSMUSP00000143859
NCBI entrez gene - 22215     See in Manteia.
MGI - MGI:105098
RefSeq - XM_017322125
RefSeq - NM_001033962
RefSeq - NM_011668
RefSeq - NM_173010
RefSeq - XM_006540799
RefSeq - XM_006540800
RefSeq - XM_006540801
RefSeq - XM_006540803
RefSeq - XM_011250847
RefSeq Peptide - NP_035798
RefSeq Peptide - NP_001029134
RefSeq Peptide - NP_766598
swissprot - A0A0J9YV26
swissprot - O08759
swissprot - A0A0J9YUK0
swissprot - A0A0J9YUF2
swissprot - A0A0J9YTX6
swissprot - A0A140LHS2
swissprot - A0A0J9YUY4
swissprot - A0A140LI50
swissprot - A0A0J9YVG1
Ensembl - ENSMUSG00000025326
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube3aENSDARG00000055737Danio rerio
 UBE3AENSGALG00000034944Gallus gallus
 UBE3AENSG00000114062Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hectd2 / Q8CDU6 / Probable E3 ubiquitin-protein ligase HECTD2 / Q5U5R9* / HECT domain E3 ubiquitin protein ligase 2*ENSMUSG0000004118027
Herc4 / Q6PAV2 / Probable E3 ubiquitin-protein ligase HERC4 / Q5GLZ8* / HECT and RLD domain containing E3 ubiquitin protein ligase 4*ENSMUSG0000002006424
Herc3 / HECT and RLD domain containing E3 ubiquitin protein ligase 3 / Q15034*ENSMUSG0000002980424
Herc6 / F2Z461 / E3 ISG15--protein ligase Herc6 / Q8IVU3* / HECT and RLD domain containing E3 ubiquitin protein ligase family member 6*ENSMUSG0000002979820
Hectd3 / Q3U487 / E3 ubiquitin-protein ligase HECTD3 / Q5T447* / HECT domain E3 ubiquitin protein ligase 3*ENSMUSG0000004686114
Herc1 / HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 / Q15751*ENSMUSG0000003866413
Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*ENSMUSG0000003045113
Rccd1 / Q8BTU7 / RCC1 domain-containing protein 1 / A6NED2* / RCC1 domain containing 1*ENSMUSG000000389301


Protein motifs (from Interpro)
Interpro ID Name
 IPR000569  HECT domain
 IPR017134  Ubiquitin-protein ligase E3A
 IPR032353  Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain
 IPR035983  HECT, E3 ligase catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001541 ovarian follicle development IMP
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IDA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030521 androgen receptor signaling pathway IPI
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0035037 sperm entry IMP
 biological_processGO:0042220 response to cocaine IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0042752 regulation of circadian rhythm IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050847 progesterone receptor signaling pathway IEA
 biological_processGO:0051865 protein autoubiquitination IEA
 biological_processGO:0060736 prostate gland growth IMP
 biological_processGO:0061002 negative regulation of dendritic spine morphogenesis IEA
 biological_processGO:0070936 protein K48-linked ubiquitination IEA
 biological_processGO:1990416 cellular response to brain-derived neurotrophic factor stimulus IEA
 biological_processGO:2000058 regulation of ubiquitin-dependent protein catabolic process IEA
 cellular_componentGO:0000502 proteasome complex IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity ISO


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

Allelic Composition: Ube3atm1Jwf/Ube3a+
Genetic Background: B6.129S4-Ube3atm1Jwf

Allelic Composition: Snhg14tm1Alb/Snhg14+,Ube3atm1Alb/Ube3a+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ube3atm1Yelg/Ube3a+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPasCrl

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Ube3atm1Yelg/Ube3a+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPasCrl * C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

Allelic Composition: Ube3atm1Jwf/Ube3a+
Genetic Background: B6.129S4-Ube3atm1Jwf

Allelic Composition: Snhg14tm1Alb/Snhg14+,Ube3atm1Alb/Ube3a+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ube3atm1Yelg/Ube3a+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPasCrl

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Ube3atm1Yelg/Ube3a+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPasCrl * C57BL/6J

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

 MP:0001447 abnormal nest building behavior "deviation from the usual behavior of mice to build sleeping nests out of any available materials; also of female mice to bulid nests to protect offspring" [J:42758, What s wrong with my mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Ube3atm1Yelg/Ube3a+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPasCrl

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Ube3atm1Yelg/Ube3a+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPasCrl * C57BL/6J

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Eif2ak2tm1Jcbe/Eif2ak2tm1Jcbe
Genetic Background: involves: 129S4/SvJae

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

 MP:0001496 audiogenic seizures "a reflex seizure triggered by loud noises" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ube3atm1Alb/Ube3a+
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Ube3atm1Yelg/Ube3a+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPasCrl

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Ube3atm1Yelg/Ube3a+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPasCrl * C57BL/6J

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eif2ak2tm1Jcbe/Eif2ak2tm1Jcbe
Genetic Background: involves: 129S4/SvJae

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ube3atm1Jwf/Ube3a+
Genetic Background: B6.129S4-Ube3atm1Jwf

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001906 increased dopamine level "greater than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eif2ak2tm1Jcbe/Eif2ak2tm1Jcbe
Genetic Background: involves: 129S4/SvJae

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Eif2ak2tm1Jcbe/Eif2ak2tm1Jcbe
Genetic Background: involves: 129S4/SvJae

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

 MP:0002175 low brain weight "lower than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ube3atm1Jwf/Ube3a+
Genetic Background: B6.129S4-Ube3atm1Jwf

 MP:0002207 abnormal long term potentiation "alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Ube3atm1Yelg/Ube3a+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPasCrl * C57BL/6J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

Allelic Composition: Ube3atm1Jwf/Ube3a+
Genetic Background: B6.129S4-Ube3atm1Jwf

 MP:0002572 abnormal emotion/affect behavior "altered response in tests for emotional related behaviors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

Allelic Composition: Snhg14tm1Alb/Snhg14+,Ube3atm1Alb/Ube3a+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ube3atm1Yelg/Ube3a+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPasCrl

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Ube3atm1Yelg/Ube3a+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPasCrl * C57BL/6J

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002803 abnormal operant conditional behavior "defects in the operant conditioning system refers to abnormalities in scheduled controlled behavior; behavioral assessment occurs in an automated chamber where responses are reinforced with food" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

 MP:0003123 paternal imprinting "specific loci are inactivated during spermatogenesis and are not expressed in offspring " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator, llw2:Linda Washburn, Mouse Genome Informatics Curator]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

Allelic Composition: Ube3atm1Yelg/Ube3a+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPasCrl

 MP:0003216 absence seizures "impairment of consciousness without convulsions associated with widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)" [RGD:Rat Genome Database submission]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

 MP:0003356 impaired lutenization "atypical transformation of the mature ovarian follicle and its theca interna into a corpus luteum after ovulation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:57854, J:43075]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003360 depression-related behavior 
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Allelic Composition: Ube3atm1Yelg/Ube3a+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPasCrl

Allelic Composition: Tg(CAG-cre/Esr1*)5Amc/0,Ube3atm1Yelg/Ube3a+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPasCrl * C57BL/6J

 MP:0003666 impaired sperm capacitation "anomaly in the change undergone by spermatozoa in the female genital tract that enables them to penetrate and fertilize an egg" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96669]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003962 abnormal adrenaline level "aberrant concentration in the blood or tissues of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

 MP:0003997 tonic-clonic seizures "increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

Allelic Composition: Ube3atm1Alb/Ube3a+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-5tm3.1Mwc/Nkx2-5tm3.1Mwc
Genetic Background: B6J.Cg-Nkx2-5tm3.1Mwc/Mwc

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004905 decreased uterus weight "reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004962 decreased prostate weight "reduction in the average weight of the gland in males that secretes part of the seminiferous fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004994 abnormal brain wave pattern "any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

Allelic Composition: Ube3atm1Jwf/Ube3a+
Genetic Background: B6.129S4-Ube3atm1Jwf

 MP:0005156 bradykinesia "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0006269 abnormal mammary gland growth during pregnancy "anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

 MP:0008840 abnormal spike wave discharge "anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy" [PMID:16725200]
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Allelic Composition: Ube3atm1Jwf/Ube3a+
Genetic Background: B6.129S4-Ube3atm1Jwf

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Acancmd/Acancmd
Genetic Background: involves: STOCK T tlow Itpr3tf

Allelic Composition: Ube3atm1Jwf/Ube3a+
Genetic Background: B6.129S4-Ube3atm1Jwf

 MP:0010069 increased serotonin concentration "increase in the amount per unit of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Ebf2tm2(Zfp423)Reed/Ebf2+,Omptm4(cre)Mom/Omp+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Ube3atm1Alb/Ube3atm1Alb
Genetic Background: involves: 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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