ENSMUSG00000029804


Mus musculus

Features
Gene ID: ENSMUSG00000029804
  
Biological name :Herc3
  
Synonyms : HECT and RLD domain containing E3 ubiquitin protein ligase 3 / Herc3
  
Possible biological names infered from orthology : Q15034
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B3
Gene start: 58831465
Gene end: 58920398
  
Corresponding Affymetrix probe sets: 10538658 (MoGene1.0st)   1431202_at (Mouse Genome 430 2.0 Array)   1433590_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031823
Ensembl peptide - ENSMUSP00000145319
Ensembl peptide - ENSMUSP00000145273
Ensembl peptide - ENSMUSP00000122762
Ensembl peptide - ENSMUSP00000122401
Ensembl peptide - ENSMUSP00000119115
Ensembl peptide - ENSMUSP00000040025
NCBI entrez gene - 73998     See in Manteia.
MGI - MGI:1921248
RefSeq - XM_006506701
RefSeq - NM_028705
RefSeq - XM_006506695
RefSeq - XM_006506696
RefSeq - XM_006506697
RefSeq - XM_006506698
RefSeq - XM_006506699
RefSeq Peptide - NP_082981
swissprot - D3Z2S3
swissprot - A6H6S0
swissprot - A0A0N4SW02
swissprot - A0A0N4SVW7
swissprot - G5E876
swissprot - D3Z6D4
swissprot - D3Z3U0
Ensembl - ENSMUSG00000029804
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 herc3ENSDARG00000075887Danio rerio
 HERC3ENSGALG00000010363Gallus gallus
 HERC3ENSG00000138641Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Herc4 / Q6PAV2 / Probable E3 ubiquitin-protein ligase HERC4 / Q5GLZ8* / HECT and RLD domain containing E3 ubiquitin protein ligase 4*ENSMUSG0000002006455
Herc6 / F2Z461 / E3 ISG15--protein ligase Herc6 / Q8IVU3* / HECT and RLD domain containing E3 ubiquitin protein ligase family member 6*ENSMUSG0000002979836
Hectd2 / Q8CDU6 / Probable E3 ubiquitin-protein ligase HECTD2 / Q5U5R9* / HECT domain E3 ubiquitin protein ligase 2*ENSMUSG0000004118022
Herc1 / HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 / Q15751*ENSMUSG0000003866420
Ube3a / O08759 / ubiquitin protein ligase E3A / Q05086*ENSMUSG0000002532620
Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*ENSMUSG0000003045119
Hectd3 / Q3U487 / E3 ubiquitin-protein ligase HECTD3 / Q5T447* / HECT domain E3 ubiquitin protein ligase 3*ENSMUSG0000004686114
Rccd1 / Q8BTU7 / RCC1 domain-containing protein 1 / A6NED2* / RCC1 domain containing 1*ENSMUSG000000389307


Protein motifs (from Interpro)
Interpro ID Name
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR000569  HECT domain
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
 IPR035983  HECT, E3 ligase catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001391 abnormal tail movements "a change from the normal manner of moving the tail" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0001512 trunk curl "posture of the trunk in a curled position" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hdac8tm1a(EUCOMM)Wtsi/Hdac8tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Hdac8tm1a(EUCOMM)Wtsi/Wtsi

 MP:0009759 abnormal hair follicle bulge "an anomaly in the area located in the bottom of the permanent portion of a resting (telogen) hair follicle where the cells of the external root sheath of the hair follicle are contiguous with the basal layer of the epidermis; this portion of the follicle is involved in the generation of a new hair at the onset of the hair growth cycle (anagen)" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mysm1tm1a(KOMP)Wtsi/Mysm1tm1a(KOMP)Wtsi
Genetic Background: C57BL/6-Mysm1tm1a(KOMP)Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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