ENSMUSG00000038664


Mus musculus

Features
Gene ID: ENSMUSG00000038664
  
Biological name :Herc1
  
Synonyms : HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 / Herc1
  
Possible biological names infered from orthology : Q15751
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: C
Gene start: 66350450
Gene end: 66508775
  
Corresponding Affymetrix probe sets: 10586505 (MoGene1.0st)   1425378_at (Mouse Genome 430 2.0 Array)   1434060_at (Mouse Genome 430 2.0 Array)   1440437_at (Mouse Genome 430 2.0 Array)   1450655_at (Mouse Genome 430 2.0 Array)   1454722_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044801
Ensembl peptide - ENSMUSP00000119991
NCBI entrez gene - 235439     See in Manteia.
MGI - MGI:2384589
RefSeq - XM_017313338
RefSeq - XM_006511107
RefSeq - XM_006511108
RefSeq - XM_017313337
RefSeq - NM_145617
RefSeq - XM_006511103
RefSeq - XM_006511104
RefSeq - XM_006511105
RefSeq - XM_006511106
RefSeq Peptide - NP_663592
swissprot - F6RXM1
swissprot - E9PZP8
Ensembl - ENSMUSG00000038664
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 herc1ENSDARG00000077901Danio rerio
 HERC1ENSGALG00000003381Gallus gallus
 HERC1ENSG00000103657Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*ENSMUSG0000003045125
Herc6 / F2Z461 / E3 ISG15--protein ligase Herc6 / Q8IVU3* / HECT and RLD domain containing E3 ubiquitin protein ligase family member 6*ENSMUSG000000297984
Herc4 / Q6PAV2 / Probable E3 ubiquitin-protein ligase HERC4 / Q5GLZ8* / HECT and RLD domain containing E3 ubiquitin protein ligase 4*ENSMUSG000000200644
Herc3 / HECT and RLD domain containing E3 ubiquitin protein ligase 3 / Q15034*ENSMUSG000000298044
Hectd3 / Q3U487 / E3 ubiquitin-protein ligase HECTD3 / Q5T447* / HECT domain E3 ubiquitin protein ligase 3*ENSMUSG000000468613
Rccd1 / Q8BTU7 / RCC1 domain-containing protein 1 / A6NED2* / RCC1 domain containing 1*ENSMUSG000000389302
Ube3a / O08759 / ubiquitin protein ligase E3A / Q05086*ENSMUSG000000253262
Hectd2 / Q8CDU6 / Probable E3 ubiquitin-protein ligase HECTD2 / Q5U5R9* / HECT domain E3 ubiquitin protein ligase 2*ENSMUSG000000411802


Protein motifs (from Interpro)
Interpro ID Name
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR000569  HECT domain
 IPR001680  WD40 repeat
 IPR001870  B30.2/SPRY domain
 IPR003877  SPRY domain
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR035768  HERC1, SPRY domain
 IPR035983  HECT, E3 ligase catalytic domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010507 negative regulation of autophagy IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0021702 cerebellar Purkinje cell differentiation IMP
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Slc8a1tm1Hssh/Slc8a1tm1Hssh,Tg(Myh6-SLC8A1)AMord/?
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Slc8a1tm1Hssh/Slc8a1tm1Hssh,Tg(Myh6-SLC8A1)AMord/?
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Slc8a1tm1Hssh/Slc8a1tm1Hssh,Tg(Myh6-SLC8A1)AMord/?
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Slc8a1tm1Hssh/Slc8a1tm1Hssh,Tg(Myh6-SLC8A1)AMord/?
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Slc8a1tm1Hssh/Slc8a1tm1Hssh,Tg(Myh6-SLC8A1)AMord/?
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc8a1tm1Hssh/Slc8a1tm1Hssh,Tg(Myh6-SLC8A1)AMord/?
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Slc8a1tm1Hssh/Slc8a1tm1Hssh,Tg(Myh6-SLC8A1)AMord/?
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Slc8a1tm1Hssh/Slc8a1tm1Hssh,Tg(Myh6-SLC8A1)AMord/?
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc8a1tm1Hssh/Slc8a1tm1Hssh,Tg(Myh6-SLC8A1)AMord/?
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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