ENSMUSG00000041180


Mus musculus

Features
Gene ID: ENSMUSG00000041180
  
Biological name :Hectd2
  
Synonyms : Hectd2 / Probable E3 ubiquitin-protein ligase HECTD2 / Q8CDU6
  
Possible biological names infered from orthology : HECT domain E3 ubiquitin protein ligase 2 / Q5U5R9
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C2
Gene start: 36554639
Gene end: 36621135
  
Corresponding Affymetrix probe sets: 10462702 (MoGene1.0st)   1433944_at (Mouse Genome 430 2.0 Array)   1446224_at (Mouse Genome 430 2.0 Array)   1446430_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120791
Ensembl peptide - ENSMUSP00000134964
Ensembl peptide - ENSMUSP00000128387
Ensembl peptide - ENSMUSP00000042646
Ensembl peptide - ENSMUSP00000117273
NCBI entrez gene - 226098     See in Manteia.
MGI - MGI:2442663
RefSeq - XM_006526991
RefSeq - XM_017318161
RefSeq - XM_017318160
RefSeq - XM_017318159
RefSeq - NM_001163471
RefSeq - NM_172637
RefSeq Peptide - NP_001156943
RefSeq Peptide - NP_766225
swissprot - Q8CDU6
swissprot - D6RI27
swissprot - B2RPZ5
swissprot - H3BJF4
swissprot - D6REW0
Ensembl - ENSMUSG00000041180
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hectd2ENSDARG00000061194Danio rerio
 HECTD2ENSGALG00000038043Gallus gallus
 HECTD2ENSG00000165338Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ube3a / O08759 / ubiquitin protein ligase E3A / Q05086*ENSMUSG0000002532631
Herc4 / Q6PAV2 / Probable E3 ubiquitin-protein ligase HERC4 / Q5GLZ8* / HECT and RLD domain containing E3 ubiquitin protein ligase 4*ENSMUSG0000002006429
Herc3 / HECT and RLD domain containing E3 ubiquitin protein ligase 3 / Q15034*ENSMUSG0000002980429
Herc6 / F2Z461 / E3 ISG15--protein ligase Herc6 / Q8IVU3* / HECT and RLD domain containing E3 ubiquitin protein ligase family member 6*ENSMUSG0000002979822
Hectd3 / Q3U487 / E3 ubiquitin-protein ligase HECTD3 / Q5T447* / HECT domain E3 ubiquitin protein ligase 3*ENSMUSG0000004686115
Herc1 / HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 / Q15751*ENSMUSG0000003866414
Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*ENSMUSG0000003045114
Rccd1 / Q8BTU7 / RCC1 domain-containing protein 1 / A6NED2* / RCC1 domain containing 1*ENSMUSG000000389302


Protein motifs (from Interpro)
Interpro ID Name
 IPR000569  HECT domain
 IPR035983  HECT, E3 ligase catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016567 protein ubiquitination IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISO
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000149 abnormal scapula morphology "malformation of either or both of the large, flat bones of the back part of the shoulder" [J:13049]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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