ENSMUSG00000020064


Mus musculus

Features
Gene ID: ENSMUSG00000020064
  
Biological name :Herc4
  
Synonyms : Herc4 / Probable E3 ubiquitin-protein ligase HERC4 / Q6PAV2
  
Possible biological names infered from orthology : HECT and RLD domain containing E3 ubiquitin protein ligase 4 / Q5GLZ8
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B4
Gene start: 63243810
Gene end: 63317878
  
Corresponding Affymetrix probe sets: 10363641 (MoGene1.0st)   1427032_at (Mouse Genome 430 2.0 Array)   1431716_at (Mouse Genome 430 2.0 Array)   1438814_at (Mouse Genome 430 2.0 Array)   1444599_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020258
Ensembl peptide - ENSMUSP00000151505
Ensembl peptide - ENSMUSP00000151886
NCBI entrez gene - 67345     See in Manteia.
MGI - MGI:1914595
RefSeq - XM_006513990
RefSeq - NM_026101
RefSeq - NM_030114
RefSeq - XM_006513986
RefSeq - XM_006513987
RefSeq - XM_006513988
RefSeq - XM_006513989
RefSeq - XM_006513985
RefSeq Peptide - NP_080377
RefSeq Peptide - NP_084390
swissprot - Q6PAV2
swissprot - A0A1W2P735
Ensembl - ENSMUSG00000020064
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 herc4ENSDARG00000059936Danio rerio
 HERC4ENSGALG00000003861Gallus gallus
 HERC4ENSG00000148634Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Herc3 / HECT and RLD domain containing E3 ubiquitin protein ligase 3 / Q15034*ENSMUSG0000002980455
Herc6 / F2Z461 / E3 ISG15--protein ligase Herc6 / Q8IVU3* / HECT and RLD domain containing E3 ubiquitin protein ligase family member 6*ENSMUSG0000002979834
Hectd2 / Q8CDU6 / Probable E3 ubiquitin-protein ligase HECTD2 / Q5U5R9* / HECT domain E3 ubiquitin protein ligase 2*ENSMUSG0000004118021
Ube3a / O08759 / ubiquitin protein ligase E3A / Q05086*ENSMUSG0000002532620
Herc2 / Q4U2R1 / E3 ubiquitin-protein ligase HERC2 / O95714* / HECT and RLD domain containing E3 ubiquitin protein ligase 2*ENSMUSG0000003045120
Herc1 / HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 / Q15751*ENSMUSG0000003866420
Hectd3 / Q3U487 / E3 ubiquitin-protein ligase HECTD3 / Q5T447* / HECT domain E3 ubiquitin protein ligase 3*ENSMUSG0000004686114
Rccd1 / Q8BTU7 / RCC1 domain-containing protein 1 / A6NED2* / RCC1 domain containing 1*ENSMUSG000000389307


Protein motifs (from Interpro)
Interpro ID Name
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR000569  HECT domain
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
 IPR035983  HECT, E3 ligase catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0030154 cell differentiation IEA
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity TAS
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity TAS


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Tgfb3tm2(Tgfb1)Vk/Tgfb3tm2(Tgfb1)Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Tgfb3tm2(Tgfb1)Vk/Tgfb3tm2(Tgfb1)Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tgfb3tm2(Tgfb1)Vk/Tgfb3tm2(Tgfb1)Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0009237 kinked sperm flagellum "a sharp bend or zigzag in the sperm tail" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tgfb3tm2(Tgfb1)Vk/Tgfb3tm2(Tgfb1)Vk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr