ENSG00000148634


Homo sapiens

Features
Gene ID: ENSG00000148634
  
Biological name :HERC4
  
Synonyms : HECT and RLD domain containing E3 ubiquitin protein ligase 4 / HERC4 / Q5GLZ8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q21.3
Gene start: 67921899
Gene end: 68075348
  
Corresponding Affymetrix probe sets: 208054_at (Human Genome U133 Plus 2.0 Array)   208055_s_at (Human Genome U133 Plus 2.0 Array)   225988_at (Human Genome U133 Plus 2.0 Array)   225989_at (Human Genome U133 Plus 2.0 Array)   232026_at (Human Genome U133 Plus 2.0 Array)   233509_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422383
Ensembl peptide - ENSP00000416504
Ensembl peptide - ENSP00000423671
Ensembl peptide - ENSP00000427191
Ensembl peptide - ENSP00000426563
Ensembl peptide - ENSP00000277817
Ensembl peptide - ENSP00000362804
Ensembl peptide - ENSP00000378624
Ensembl peptide - ENSP00000406171
NCBI entrez gene - 26091     See in Manteia.
OMIM - 609248
RefSeq - XM_017016041
RefSeq - NM_001278186
RefSeq - NM_001278187
RefSeq - NM_015601
RefSeq - NM_022079
RefSeq - XM_011539592
RefSeq - XM_011539593
RefSeq - XM_011539594
RefSeq - XM_011539595
RefSeq - XM_011539596
RefSeq - XM_011539597
RefSeq - NM_001278185
RefSeq Peptide - NP_001265115
RefSeq Peptide - NP_001265116
RefSeq Peptide - NP_056416
RefSeq Peptide - NP_071362
RefSeq Peptide - NP_001265114
swissprot - D6RFK9
swissprot - D6RCL5
swissprot - H0Y6K7
swissprot - Q5GLZ8
swissprot - A0A024QZN8
Ensembl - ENSG00000148634
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 herc4ENSDARG00000059936Danio rerio
 HERC4ENSGALG00000003861Gallus gallus
 Herc4ENSMUSG00000020064Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HERC3 / Q15034 / HECT and RLD domain containing E3 ubiquitin protein ligase 3ENSG0000013864156
HERC6 / Q8IVU3 / HECT and RLD domain containing E3 ubiquitin protein ligase family member 6ENSG0000013864236
HERC5 / Q9UII4 / HECT and RLD domain containing E3 ubiquitin protein ligase 5ENSG0000013864634
HECTD2 / Q5U5R9 / HECT domain E3 ubiquitin protein ligase 2ENSG0000016533821
HERC2 / O95714 / HECT and RLD domain containing E3 ubiquitin protein ligase 2ENSG0000012873120
UBE3A / Q05086 / ubiquitin protein ligase E3AENSG0000011406220
HERC1 / Q15751 / HECT and RLD domain containing E3 ubiquitin protein ligase family member 1ENSG0000010365719
HECTD3 / Q5T447 / HECT domain E3 ubiquitin protein ligase 3ENSG0000012610713
RCCD1 / A6NED2 / RCC1 domain containing 1ENSG000001669658
AC098582.1ENSG000002853854


Protein motifs (from Interpro)
Interpro ID Name
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR000569  HECT domain
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
 IPR035983  HECT, E3 ligase catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007283 spermatogenesis ISS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030154 cell differentiation IEA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr