ENSG00000080839


Homo sapiens

Features
Gene ID: ENSG00000080839
  
Biological name :RBL1
  
Synonyms : P28749 / RBL1 / RB transcriptional corepressor like 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q11.23
Gene start: 36996349
Gene end: 37095995
  
Corresponding Affymetrix probe sets: 1555003_at (Human Genome U133 Plus 2.0 Array)   1555004_a_at (Human Genome U133 Plus 2.0 Array)   1559307_s_at (Human Genome U133 Plus 2.0 Array)   205296_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000437240
Ensembl peptide - ENSP00000343646
Ensembl peptide - ENSP00000362768
Ensembl peptide - ENSP00000434711
NCBI entrez gene - 5933     See in Manteia.
OMIM - 116957
RefSeq - XM_017027992
RefSeq - NM_001323281
RefSeq - NM_001323282
RefSeq - NM_002895
RefSeq - NM_183404
RefSeq - XM_006723842
RefSeq - XM_011528955
RefSeq - XM_011528958
RefSeq Peptide - NP_899662
RefSeq Peptide - NP_001310210
RefSeq Peptide - NP_001310211
RefSeq Peptide - NP_002886
swissprot - P28749
swissprot - H0YE05
swissprot - E9PNB6
Ensembl - ENSG00000080839
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbl1ENSDARG00000008141Danio rerio
 RBL1ENSGALG00000001332Gallus gallus
 Rbl1ENSMUSG00000027641Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RBL2 / Q08999 / RB transcriptional corepressor like 2ENSG0000010347951
RB1 / P06400 / RB transcriptional corepressor 1ENSG0000013968723


Protein motifs (from Interpro)
Interpro ID Name
 IPR002719  Retinoblastoma-associated protein, B-box
 IPR002720  Retinoblastoma-associated protein, A-box
 IPR013763  Cyclin-like
 IPR015030  Retinoblastoma-associated protein, C-terminal
 IPR024599  Retinoblastoma-associated protein, N-terminal
 IPR028309  Retinoblastoma protein family
 IPR028310  Retinoblastoma-like protein 1
 IPR036915  Cyclin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0016032 viral process IEA
 biological_processGO:0043550 regulation of lipid kinase activity IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II TAS
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:2000773 negative regulation of cellular senescence IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:1990841 promoter-specific chromatin binding IDA


Pathways (from Reactome)
Pathway description
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Activation of E2F1 target genes at G1/S
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Cyclin D associated events in G1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110092 CCND1 / P24385 / cyclin D1  / reaction
 ENSG00000111276 CDKN1B / P46527 / cyclin dependent kinase inhibitor 1B  / reaction
 ENSG00000124762 CDKN1A / P38936 / cyclin dependent kinase inhibitor 1A  / reaction
 ENSG00000175387 SMAD2 / Q15796 / SMAD family member 2  / complex / reaction
 ENSG00000123374 CDK2 / P24941 / cyclin dependent kinase 2  / reaction / complex
 ENSG00000135446 CDK4 / P11802 / cyclin dependent kinase 4  / reaction
 ENSG00000166949 SMAD3 / P84022 / SMAD family member 3  / reaction / complex
 ENSG00000141646 SMAD4 / Q13485 / SMAD family member 4  / complex / reaction
 ENSG00000133740 E2F5 / Q15329 / E2F transcription factor 5  / complex
 ENSG00000205250 E2F4 / Q16254 / E2F transcription factor 4  / complex
 ENSG00000116478 HDAC1 / Q13547 / histone deacetylase 1  / complex / reaction
 ENSG00000198176 TFDP1 / Q14186 / transcription factor Dp-1  / complex
 ENSG00000114126 TFDP2 / Q14188 / transcription factor Dp-2  / complex






 

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