ENSG00000136488


Homo sapiens

Features
Gene ID: ENSG00000136488
  
Biological name :CSH1
  
Synonyms : chorionic somatomammotropin hormone 1 / CSH1 / P0DML2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q23.3
Gene start: 63894909
Gene end: 63896661
  
Corresponding Affymetrix probe sets: 202493_x_at (Human Genome U133 Plus 2.0 Array)   203807_x_at (Human Genome U133 Plus 2.0 Array)   205958_x_at (Human Genome U133 Plus 2.0 Array)   206475_x_at (Human Genome U133 Plus 2.0 Array)   207285_x_at (Human Genome U133 Plus 2.0 Array)   208293_x_at (Human Genome U133 Plus 2.0 Array)   208294_x_at (Human Genome U133 Plus 2.0 Array)   208295_x_at (Human Genome U133 Plus 2.0 Array)   208341_x_at (Human Genome U133 Plus 2.0 Array)   208342_x_at (Human Genome U133 Plus 2.0 Array)   208356_x_at (Human Genome U133 Plus 2.0 Array)   208357_x_at (Human Genome U133 Plus 2.0 Array)   211739_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000316416
Ensembl peptide - ENSP00000478652
Ensembl peptide - ENSP00000402517
Ensembl peptide - ENSP00000333268
NCBI entrez gene - 1442     See in Manteia.
OMIM - 150200
RefSeq - NM_001317
RefSeq Peptide - NP_001308
swissprot - A0A087WUG6
swissprot - B1A4H2
swissprot - P0DML2
swissprot - A8K6C2
swissprot - A6NFB4
Ensembl - ENSG00000136488
  
Related genetic diseases (OMIM): 150200 - [Placental lactogen deficiency]
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gh1ENSDARG00000038185Danio rerio
 GHENSGALG00000000249Gallus gallus
 GhENSMUSG00000020713Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CSH2 / P0DML3 / chorionic somatomammotropin hormone 2ENSG00000213218100
CSHL1 / Q14406 / chorionic somatomammotropin hormone like 1ENSG0000020441492
GH1 / P01241 / growth hormone 1ENSG0000025938485
GH2 / P01242 / growth hormone 2ENSG0000013648757


Protein motifs (from Interpro)
Interpro ID Name
 IPR001400  Somatotropin/prolactin
 IPR009079  Four-helical cytokine-like, core
 IPR018116  Somatotropin hormone, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway TAS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0031904 endosome lumen TAS
 cellular_componentGO:0031982 vesicle IDA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Prolactin receptor signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex / reaction
 ENSG00000113494 PRLR / P16471 / prolactin receptor  / complex / reaction
 ENSG00000172179 PRL / P01236 / prolactin  / complex
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / reaction / complex
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / complex
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / complex
 ENSG00000173757 P51692 / STAT5B / signal transducer and activator of transcription 5B  / complex / reaction
 ENSG00000136488 CSH1 / P0DML2 / chorionic somatomammotropin hormone 1  / complex
 ENSG00000178188 SH2B1 / Q9NRF2 / SH2B adaptor protein 1  / complex / reaction
 ENSG00000126561 P42229 / STAT5A / signal transducer and activator of transcription 5A  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction / complex
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / reaction / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex






 

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