ENSG00000172179


Homo sapiens

Features
Gene ID: ENSG00000172179
  
Biological name :PRL
  
Synonyms : P01236 / PRL / prolactin
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p22.3
Gene start: 22287244
Gene end: 22297501
  
Corresponding Affymetrix probe sets: 205445_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000480195
Ensembl peptide - ENSP00000302150
Ensembl peptide - ENSP00000478566
NCBI entrez gene - 5617     See in Manteia.
OMIM - 176760
RefSeq - XM_011514754
RefSeq - NM_000948
RefSeq - NM_001163558
RefSeq - XM_011514753
RefSeq Peptide - NP_001157030
RefSeq Peptide - NP_000939
swissprot - P01236
swissprot - Q5I0G2
swissprot - Q5THQ0
swissprot - A6XMH3
Ensembl - ENSG00000172179
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prlENSDARG00000037946Danio rerio
 prlENSGALG00000012671Gallus gallus
 O35256ENSMUSG00000005891Mus musculus
 O35257ENSMUSG00000069259Mus musculus
 P04095ENSMUSG00000079092Mus musculus
 P04768ENSMUSG00000056457Mus musculus
 P04769ENSMUSG00000021348Mus musculus
 P09586ENSMUSG00000038891Mus musculus
 PrlENSMUSG00000021342Mus musculus
 Prl2a1ENSMUSG00000022886Mus musculus
 Prl2b1ENSMUSG00000069258Mus musculus
 Prl2c1ENSMUSG00000062551Mus musculus
 Prl2c5ENSMUSG00000055360Mus musculus
 Prl3a1ENSMUSG00000038883Mus musculus
 Prl3c1ENSMUSG00000017922Mus musculus
 Prl3d1ENSMUSG00000057170Mus musculus
 Prl3d2ENSMUSG00000062737Mus musculus
 Prl3d3ENSMUSG00000062201Mus musculus
 Prl5a1ENSMUSG00000017064Mus musculus
 Prl7b1ENSMUSG00000021347Mus musculus
 Prl7c1ENSMUSG00000060738Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001400  Somatotropin/prolactin
 IPR009079  Four-helical cytokine-like, core
 IPR018116  Somatotropin hormone, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IDA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007565 female pregnancy NAS
 biological_processGO:0007595 lactation IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016525 negative regulation of angiogenesis NAS
 biological_processGO:0040014 regulation of multicellular organism growth IEP
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IDA
 biological_processGO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway TAS
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0031904 endosome lumen TAS
 molecular_functionGO:0005148 prolactin receptor binding TAS
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Prolactin receptor signaling
Amyloid fiber formation
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100387 RBX1 / P62877 / ring-box 1  / complex / reaction
 ENSG00000113494 PRLR / P16471 / prolactin receptor  / complex / reaction
 ENSG00000172179 PRL / P01236 / prolactin  / - / complex
 ENSG00000136488 CSH1 / P0DML2 / chorionic somatomammotropin hormone 1  / complex
 ENSG00000178188 SH2B1 / Q9NRF2 / SH2B adaptor protein 1  / reaction / complex
 ENSG00000136487 GH2 / P01242 / growth hormone 2  / complex
 ENSG00000259384 GH1 / P01241 / growth hormone 1  / complex
 ENSG00000126561 P42229 / STAT5A / signal transducer and activator of transcription 5A  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / complex / reaction
 ENSG00000173757 P51692 / STAT5B / signal transducer and activator of transcription 5B  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex






 

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