ENSMUSG00000021342


Mus musculus

Features
Gene ID: ENSMUSG00000021342
  
Biological name :Prl
  
Synonyms : P06879 / Prl / prolactin
  
Possible biological names infered from orthology : P01236
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.1
Gene start: 27057570
Gene end: 27065205
  
Corresponding Affymetrix probe sets: 10404264 (MoGene1.0st)   1429287_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018061
Ensembl peptide - ENSMUSP00000105998
Ensembl peptide - ENSMUSP00000153245
NCBI entrez gene - 19109     See in Manteia.
MGI - MGI:97762
RefSeq - XM_017315423
RefSeq - NM_001163530
RefSeq - NM_011164
RefSeq Peptide - NP_035294
RefSeq Peptide - NP_001157002
swissprot - P06879
swissprot - Q9CPQ0
swissprot - Q9CPQ2
Ensembl - ENSMUSG00000021342
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prlENSDARG00000037946Danio rerio
 prlENSGALG00000012671Gallus gallus
 PRLENSG00000172179Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prl3b1 / P09586 / prolactin family 3, subfamily b, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000003889136
Prl2a1 / Q9JHK0 / prolactin family 2, subfamily a, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000002288636
Prl6a1 / O35257 / prolactin family 6, subfamily a, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000006925933
Prl4a1 / O35256 / prolactin family 4, subfamily a, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000000589133
Prl2c1 / Prolactin family 2, subfamily c, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000006255132
Prl7d1 / P04769 / prolactin family 7, subfamily d, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000002134832
Prl7c1 / Q9CRB5 / prolactin family 7, subfamily c, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000006073832
Prl7b1 / Q8CGZ9 / Prolactin-7B1 / PRL* / P01236* / prolactin*ENSMUSG0000002134732
Prl3d1 / prolactin family 3, subfamily d, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000005717031
Prl3a1 / prolactin family 3, subfamily a, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000003888331
Prl2b1 / Q9DAZ2 / prolactin family 2, subfamily b, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000006925831
Prl3d3 / prolactin family 3, subfamily d, member 3 / PRL* / P01236* / prolactin*ENSMUSG0000006220130
Prl3d2 / prolactin family 3, subfamily d, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000006273730
Prl5a1 / Q9JII2 / prolactin family 5, subfamily a, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000001706430
P04768 / Prl2c3 / Mus musculus prolactin family 2, subfamily c, member 4 (Prl2c4), mRNA. / PRL* / P01236* / prolactin*ENSMUSG0000005645729
Prl2c5 / Q9JLV9 / Prolactin-2C5 / PRL* / P01236* / prolactin*ENSMUSG0000005536029
Prl2c2 / P04095 / Prolactin-2C2 / PRL* / P01236* / prolactin*ENSMUSG0000007909229
Prl3c1 / Q9QUN5 / prolactin family 3, subfamily c, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000001792223


Protein motifs (from Interpro)
Interpro ID Name
 IPR001400  Somatotropin/prolactin
 IPR009079  Four-helical cytokine-like, core
 IPR018116  Somatotropin hormone, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001937 negative regulation of endothelial cell proliferation ISO
 biological_processGO:0007567 parturition IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030278 regulation of ossification IEA
 biological_processGO:0030879 mammary gland development IGI
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032870 cellular response to hormone stimulus IEA
 biological_processGO:0033555 multicellular organismal response to stress IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042698 ovulation cycle IEA
 biological_processGO:0042711 maternal behavior IGI
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0046425 regulation of JAK-STAT cascade IDA
 biological_processGO:0046427 positive regulation of JAK-STAT cascade ISO
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IEA
 biological_processGO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0030141 secretory granule IEA
 molecular_functionGO:0005148 prolactin receptor binding ISO
 molecular_functionGO:0005179 hormone activity IEA


Pathways (from Reactome)
Pathway description
Prolactin receptor signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0000633 abnormal pituitary gland morphology "anomalous structure of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0000635 pituitary gland hyperplasia "increased size of pituitary gland due to increased cell number" [J:63229, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0000636 enlarged pituitary gland "increased size of pituitary gland" [J:50053]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0000661 small ventral prostate "reduced size of lateral lobe of the prostate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63764]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0001728 failure of implantation "inability of the blastocyst to attach to the endometrium of the uterus" [J:38772]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0001746 abnormal pituitary secretion "altered ability of the pituitary to release its products" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0002041 pituitary adenoma "appearance of benign neoplasms of the pituitary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0003371 decreased circulating estrogen level "reduction in the blood concentration of any substance that causes development of the female reproductive organs and secondary sexual characteristics" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0005121 decreased circulating prolactin level "less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0005130 decreased follicle stimulating hormone level "less than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0005132 decreased luteinizing hormone level "lower than normal concentration of LH " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0005138 decreased prolactin level "less than expected concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0005181 decreased circulating estradiol level "less than the normal blood concentration of this most potent naturally occurring estrogen in mammals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0005643 decreased dopamine level "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0008325 abnormal gonadotroph morphology "any structural anomaly of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)" [MESH:A06.407.747.608.750]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0008332 decreased lactotroph cell number "reduced number of an acidophilic cell of the anterior pituitary that produces prolactin" [CL:0000439, MESH:A06.407.747.608.812]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0008939 increased pituitary gland weight "greater than average weight of the compound gland suspended from the base of the hypothalamus" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0009007 short estrous cycle "decrease in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0009014 prolonged proestrus "increase in the length of the proestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0009017 prolonged estrus "increase in the length of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

 MP:0013336 pituitary gland hypertrophy "increase in the bulk size of the pituitary gland due to cell enlargement" [MGI:Anna]
Show

Allelic Composition: Casp4tm1Yuan/Casp4tm1Yuan
Genetic Background: involves: 129S4/SvJae * C57BL/6J * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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