ENSMUSG00000017922


Mus musculus

Features
Gene ID: ENSMUSG00000017922
  
Biological name :Prl3c1
  
Synonyms : Prl3c1 / prolactin family 3, subfamily c, member 1 / Q9QUN5
  
Possible biological names infered from orthology : P01236 / PRL / prolactin
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A3.1
Gene start: 27196659
Gene end: 27203749
  
Corresponding Affymetrix probe sets: 10404287 (MoGene1.0st)   1449830_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018066
Ensembl peptide - ENSMUSP00000105993
Ensembl peptide - ENSMUSP00000136890
NCBI entrez gene - 27372     See in Manteia.
MGI - MGI:1351649
RefSeq - NM_013766
RefSeq - NM_001163218
RefSeq Peptide - NP_001156690
RefSeq Peptide - NP_038794
swissprot - Q0VBM3
swissprot - Q9QUN5
swissprot - Z4YL38
Ensembl - ENSMUSG00000017922
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prlENSDARG00000037946Danio rerio
 prlENSGALG00000012671Gallus gallus
 PRLENSG00000172179Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Prl3b1 / P09586 / prolactin family 3, subfamily b, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000003889130
Prl3d1 / prolactin family 3, subfamily d, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000005717029
Prl3d3 / prolactin family 3, subfamily d, member 3 / PRL* / P01236* / prolactin*ENSMUSG0000006220129
Prl3d2 / prolactin family 3, subfamily d, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000006273728
Prl7c1 / Q9CRB5 / prolactin family 7, subfamily c, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000006073828
Prl3a1 / prolactin family 3, subfamily a, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000003888328
Prl7d1 / P04769 / prolactin family 7, subfamily d, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000002134827
Prl2a1 / Q9JHK0 / prolactin family 2, subfamily a, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000002288627
Prl7b1 / Q8CGZ9 / Prolactin-7B1 / PRL* / P01236* / prolactin*ENSMUSG0000002134726
Prl2c2 / P04095 / Prolactin-2C2 / PRL* / P01236* / prolactin*ENSMUSG0000007909225
Prl4a1 / O35256 / prolactin family 4, subfamily a, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000000589125
Prl2c1 / Prolactin family 2, subfamily c, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000006255125
Prl / P06879 / prolactin / P01236*ENSMUSG0000002134225
P04768 / Prl2c3 / Mus musculus prolactin family 2, subfamily c, member 4 (Prl2c4), mRNA. / PRL* / P01236* / prolactin*ENSMUSG0000005645725
Prl6a1 / O35257 / prolactin family 6, subfamily a, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000006925924
Prl2b1 / Q9DAZ2 / prolactin family 2, subfamily b, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000006925824
Prl2c5 / Q9JLV9 / Prolactin-2C5 / PRL* / P01236* / prolactin*ENSMUSG0000005536024
Prl5a1 / Q9JII2 / prolactin family 5, subfamily a, member 1 / PRL* / P01236* / prolactin*ENSMUSG0000001706418


Protein motifs (from Interpro)
Interpro ID Name
 IPR001400  Somatotropin/prolactin
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005179 hormone activity IEA


Pathways (from Reactome)
Pathway description
Prolactin receptor signaling
Growth hormone receptor signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001148 enlarged testes "increased size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:63229]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

 MP:0001152 Leydig cell hyperplasia "increased number of interstitial cells of the seminiferous tubules that secrete testosterone" [J:45065]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

 MP:0001751 increased circulating luteinizing hormone level "higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35782, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

 MP:0002669 abnormal scrotum morphology "malformation of the external sac of skin that encloses the testes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

 MP:0002673 abnormal sperm count "increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

 MP:0002781 increased circulating testosterone level "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

 MP:0002997 enlarged seminal gland "increased size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

 MP:0004851 increased testis weight "greater average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

 MP:0004884 abnormal testicular physiology "anomaly or loss either the production of male germ cells or the endocrine cells for the production testosterone" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

 MP:0004909 increased seminal gland weight "increase in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

 MP:0005646 abnormal pituitary gland physiology "anmalous function of this unpaired compound gland suspended from the base of the hypothalamus by a short extension of the infundibulum, the infundibular or pituitary stalk" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

 MP:0013604 abnormal adult Leydig cell differentiation "atypical formation of or inability to produce the second or adult population of Leydig cells (ALCs) between birth and puberty; ALCs arise in the interstitium of adult testes from unknown progenitor cells and become the major source of androgens that control differentiation of the male reproductive tract and spermatogenesis; ALCs are not derived from fetal Leydig cells (FLCs), and the origin and the molecular events that control ALC differentiation are poorly understood" [PMID:23568777]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-Slc39a14*L438R)Wvh/Gt(ROSA)26Sor+,Tg(Ctsk-cre)1Rda/0
Genetic Background: involves: C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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