ENSMUSG00000020372


Mus musculus

Features
Gene ID: ENSMUSG00000020372
  
Biological name :Rack1
  
Synonyms : P68040 / Rack1 / Receptor of activated protein C kinase 1 Receptor of activated protein C kinase 1, N-terminally processed
  
Possible biological names infered from orthology : P63244 / receptor for activated C kinase 1
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.2
Gene start: 48800332
Gene end: 48806434
  
Corresponding Affymetrix probe sets: 10375487 (MoGene1.0st)   10375497 (MoGene1.0st)   10375499 (MoGene1.0st)   10375501 (MoGene1.0st)   1440120_at (Mouse Genome 430 2.0 Array)   1455168_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020640
NCBI entrez gene - 14694     See in Manteia.
MGI - MGI:101849
RefSeq - NM_008143
RefSeq Peptide - NP_032169
swissprot - P68040
Ensembl - ENSMUSG00000020372
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rack1ENSDARG00000041619Danio rerio
 GNB2L1ENSGALG00000000122Gallus gallus
 RACK1ENSG00000204628Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006412 translation IMP
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0008104 protein localization ISO
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway ISS
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030822 obsolete positive regulation of cAMP catabolic process IEA
 biological_processGO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
 biological_processGO:0032464 positive regulation of protein homooligomerization IEA
 biological_processGO:0032880 regulation of protein localization ISS
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction ISO
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042998 positive regulation of Golgi to plasma membrane protein transport IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043473 pigmentation IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:0050765 negative regulation of phagocytosis IEA
 biological_processGO:0051302 regulation of cell division ISS
 biological_processGO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IEA
 biological_processGO:0051901 positive regulation of mitochondrial depolarization IEA
 biological_processGO:0061099 negative regulation of protein tyrosine kinase activity IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071363 cellular response to growth factor stimulus IEA
 biological_processGO:0072344 rescue of stalled ribosome IEA
 biological_processGO:1903208 negative regulation of hydrogen peroxide-induced neuron death IGI
 biological_processGO:2000114 regulation of establishment of cell polarity ISS
 biological_processGO:2000543 positive regulation of gastrulation ISS
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0044297 cell body IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 cellular_componentGO:1990630 IRE1-RACK1-PP2A complex IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008200 ion channel inhibitor activity IDA
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019903 protein phosphatase binding IEA
 molecular_functionGO:0030292 protein tyrosine kinase inhibitor activity IEA
 molecular_functionGO:0030332 cyclin binding IEA
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0035591 signaling adaptor activity IEA
 molecular_functionGO:0042169 SH2 domain binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043022 ribosome binding IEA
 molecular_functionGO:0045296 cadherin binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR1-mediated ceramide production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dixdc1tm1Bnrc/Dixdc1tm1Bnrc
Genetic Background: involves: 129 * C57BL/6

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dixdc1tm1Bnrc/Dixdc1tm1Bnrc
Genetic Background: involves: 129 * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Dixdc1tm1Bnrc/Dixdc1tm1Bnrc
Genetic Background: involves: 129 * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dixdc1tm1Bnrc/Dixdc1tm1Bnrc
Genetic Background: involves: 129 * C57BL/6

 MP:0001694 failure to form egg cylinders "inability of inner cell mass cells to grow towards the abembryonic pole to form a cylinder-like structure" [The Atlas of Mouse Development , Revised edition:ISBN 0-12-402035-6, MGI:cls, J:34458]
Show

Allelic Composition: Dixdc1tm1Bnrc/Dixdc1tm1Bnrc
Genetic Background: involves: 129 * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dixdc1tm1Bnrc/Dixdc1tm1Bnrc
Genetic Background: involves: 129 * C57BL/6

 MP:0005175 non-pigmented tail tip "lack of color at the end of the tail " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
Show

Allelic Composition: Dixdc1tm1Bnrc/Dixdc1tm1Bnrc
Genetic Background: involves: 129 * C57BL/6

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Dixdc1tm1Bnrc/Dixdc1tm1Bnrc
Genetic Background: involves: 129 * C57BL/6

 MP:0011277 decreased tail pigmentation "visually detectable dilution of pigment present on the tail surface" [MGI:csmith]
Show

Allelic Composition: Dixdc1tm1Bnrc/Dixdc1tm1Bnrc
Genetic Background: involves: 129 * C57BL/6

 MP:0011568 decreased foot pigmentation "visually detectable dilution of pigment present on the foot surface" [MGI:csmith]
Show

Allelic Composition: Dixdc1tm1Bnrc/Dixdc1tm1Bnrc
Genetic Background: involves: 129 * C57BL/6

 MP:0013272 abnormal translation "any anomaly in the cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain; translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA; translation ends with the release of a polypeptide chain from the ribosome" [GO:0006412]
Show

Allelic Composition: Dixdc1tm1Bnrc/Dixdc1tm1Bnrc
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004221 Ikbkg / O88522 / NF-kappa-B essential modulator / Q9Y6K9* / inhibitor of nuclear factor kappa B kinase subunit gamma*  / complex / reaction
 ENSMUSG00000031906 Smpd3 / Q9JJY3 / sphingomyelin phosphodiesterase 3, neutral / Q9NY59* / sphingomyelin phosphodiesterase 3*  / complex / reaction
 ENSMUSG00000019822 Smpd2 / O70572 / sphingomyelin phosphodiesterase 2, neutral / O60906* / sphingomyelin phosphodiesterase 2*  / complex / reaction
 ENSMUSG00000024401 Tnf / P06804 / tumor necrosis factor / P01375*  / reaction / complex
 ENSMUSG00000025199 Chuk / conserved helix-loop-helix ubiquitous kinase / O15111*  / reaction / complex
 ENSMUSG00000030341 P25118 / Tnfrsf1a / tumor necrosis factor receptor superfamily, member 1a / P19438* / TNF receptor superfamily member 1A*  / reaction / complex
 ENSMUSG00000028245 Nsmaf / O35242 / neutral sphingomyelinase (N-SMase) activation associated factor / Q92636* / neutral sphingomyelinase activation associated factor*  / reaction / complex






 

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