ENSMUSG00000056054


Mus musculus

Features
Gene ID: ENSMUSG00000056054
  
Biological name :S100a8
  
Synonyms : P27005 / S100a8 / S100 calcium binding protein A8 (calgranulin A)
  
Possible biological names infered from orthology : P05109 / S100 calcium binding protein A8
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 90668978
Gene end: 90670035
  
Corresponding Affymetrix probe sets: 10493831 (MoGene1.0st)   1419394_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064385
NCBI entrez gene - 20201     See in Manteia.
MGI - MGI:88244
RefSeq - NM_013650
RefSeq Peptide - NP_038678
swissprot - P27005
swissprot - Q53X15
Ensembl - ENSMUSG00000056054
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P05109ENSG00000143546Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001751  S100/Calbindin-D9k, conserved site
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR013787  S100/CaBP-9k-type, calcium binding, subdomain
 IPR018247  EF-Hand 1, calcium-binding site
 IPR028474  Protein S100-A8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002523 leukocyte migration involved in inflammatory response IEA
 biological_processGO:0002793 positive regulation of peptide secretion IMP
 biological_processGO:0006914 autophagy ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0014002 astrocyte development IGI
 biological_processGO:0018119 peptidyl-cysteine S-nitrosylation IEA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0070488 neutrophil aggregation IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0035662 Toll-like receptor 4 binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050544 arachidonic acid binding IEA
 molecular_functionGO:0050786 RAGE receptor binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Metal sequestration by antimicrobial proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Lman1Gt(XST010)Byg/Lman1Gt(XST010)Byg
Genetic Background: D2.129P2-Lman1Gt(XST010)Byg

Allelic Composition: S100a8tm1Hogg/S100a8tm1Hogg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Cacna1dtm1Jst/Cacna1dtm1Jst
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0011104 partial embryonic lethality before implantation "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Lman1Gt(XST010)Byg/Lman1Gt(XST010)Byg
Genetic Background: D2.129P2-Lman1Gt(XST010)Byg

Allelic Composition: S100a8tm1Hogg/S100a8tm1Hogg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / complex / reaction
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / complex / reaction
 ENSMUSG00000056054 P27005 / S100a8 / S100 calcium binding protein A8 (calgranulin A) / P05109* / S100 calcium binding protein A8*  / complex
 ENSMUSG00000056071 P31725 / S100a9 / S100 calcium binding protein A9 (calgranulin B) / P06702* / S100 calcium binding protein A9*  / complex






 

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