ENSG00000143546


Homo sapiens

Features
Gene ID: ENSG00000143546
  
Biological name :S100A8
  
Synonyms : P05109 / S100A8 / S100 calcium binding protein A8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.3
Gene start: 153390032
Gene end: 153391188
  
Corresponding Affymetrix probe sets: 202917_s_at (Human Genome U133 Plus 2.0 Array)   214370_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357721
Ensembl peptide - ENSP00000357722
NCBI entrez gene - 6279     See in Manteia.
OMIM - 123885
RefSeq - NM_002964
RefSeq - NM_001319201
RefSeq - NM_001319196
RefSeq - NM_001319197
RefSeq - NM_001319198
RefSeq Peptide - NP_001306125
RefSeq Peptide - NP_001306126
RefSeq Peptide - NP_001306127
RefSeq Peptide - NP_001306130
RefSeq Peptide - NP_002955
swissprot - P05109
Ensembl - ENSG00000143546
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P27005ENSMUSG00000056054Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001751  S100/Calbindin-D9k, conserved site
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR013787  S100/CaBP-9k-type, calcium binding, subdomain
 IPR018247  EF-Hand 1, calcium-binding site
 IPR028474  Protein S100-A8


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production TAS
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002523 leukocyte migration involved in inflammatory response IDA
 biological_processGO:0002526 acute inflammatory response IEA
 biological_processGO:0002544 chronic inflammatory response IEA
 biological_processGO:0002793 positive regulation of peptide secretion IEA
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0014002 astrocyte development IEA
 biological_processGO:0018119 peptidyl-cysteine S-nitrosylation IMP
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0030307 positive regulation of cell growth TAS
 biological_processGO:0030593 neutrophil chemotaxis IDA
 biological_processGO:0032119 sequestering of zinc ion TAS
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032602 chemokine production TAS
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0042742 defense response to bacterium TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050729 positive regulation of inflammatory response IDA
 biological_processGO:0050832 defense response to fungus TAS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
 biological_processGO:0051493 regulation of cytoskeleton organization TAS
 biological_processGO:0070488 neutrophil aggregation IDA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 cellular_componentGO:0045111 intermediate filament cytoskeleton IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005509 calcium ion binding TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008017 microtubule binding TAS
 molecular_functionGO:0008270 zinc ion binding TAS
 molecular_functionGO:0035662 Toll-like receptor 4 binding TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050544 arachidonic acid binding TAS
 molecular_functionGO:0050786 RAGE receptor binding TAS


Pathways (from Reactome)
Pathway description
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Metal sequestration by antimicrobial proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / complex / reaction
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / reaction / complex
 ENSG00000143546 P05109 / S100A8 / S100 calcium binding protein A8  / complex
 ENSG00000163220 P06702 / S100A9 / S100 calcium binding protein A9  / complex






 

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