ENSMUSG00000056071


Mus musculus

Features
Gene ID: ENSMUSG00000056071
  
Biological name :S100a9
  
Synonyms : P31725 / S100a9 / S100 calcium binding protein A9 (calgranulin B)
  
Possible biological names infered from orthology : P06702 / S100 calcium binding protein A9
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 90692632
Gene end: 90695721
  
Corresponding Affymetrix probe sets: 10499861 (MoGene1.0st)   1448756_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000070842
Ensembl peptide - ENSMUSP00000112843
NCBI entrez gene - 20202     See in Manteia.
MGI - MGI:1338947
RefSeq - NM_009114
RefSeq - NM_001281852
RefSeq Peptide - NP_001268781
RefSeq Peptide - NP_033140
swissprot - P31725
swissprot - Q3UP42
Ensembl - ENSMUSG00000056071
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P06702ENSG00000163220Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm5849ENSMUSG0000009662143


Protein motifs (from Interpro)
Interpro ID Name
 IPR001751  S100/Calbindin-D9k, conserved site
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR013787  S100/CaBP-9k-type, calcium binding, subdomain
 IPR028475  Protein S100-A9


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002523 leukocyte migration involved in inflammatory response IEA
 biological_processGO:0002793 positive regulation of peptide secretion IMP
 biological_processGO:0006417 regulation of translation IMP
 biological_processGO:0006914 autophagy ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0014002 astrocyte development IGI
 biological_processGO:0018119 peptidyl-cysteine S-nitrosylation IMP
 biological_processGO:0030194 positive regulation of blood coagulation IMP
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0030595 leukocyte chemotaxis IMP
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0035606 peptidyl-cysteine S-trans-nitrosylation IEA
 biological_processGO:0035821 modification of morphology or physiology of other organism IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045113 regulation of integrin biosynthetic process IMP
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IEA
 biological_processGO:0070488 neutrophil aggregation IEA
 biological_processGO:0098869 cellular oxidant detoxification IEA
 biological_processGO:2001244 positive regulation of intrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016209 antioxidant activity IEA
 molecular_functionGO:0035662 Toll-like receptor 4 binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050544 arachidonic acid binding IEA
 molecular_functionGO:0050786 RAGE receptor binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TLR by endogenous ligand
Neutrophil degranulation
Metal sequestration by antimicrobial proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MafOfl/MafOfl
Genetic Background: either: 102/ElH or C3H/HeH

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
Show

Allelic Composition: Ophn1tm1Bill/Y
Genetic Background: Not Specified

 MP:0011400 complete lethality "all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified" [MGI:llw2]
Show

Allelic Composition: Mboat7tm1Arai/Mboat7tm1Arai
Genetic Background: B6.129P2-Mboat7tm1Arai

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / reaction / complex
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / reaction / complex
 ENSMUSG00000056054 P27005 / S100a8 / S100 calcium binding protein A8 (calgranulin A) / P05109* / S100 calcium binding protein A8*  / complex
 ENSMUSG00000056071 P31725 / S100a9 / S100 calcium binding protein A9 (calgranulin B) / P06702* / S100 calcium binding protein A9*  / complex






 

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