ENSG00000129988


Homo sapiens

Features
Gene ID: ENSG00000129988
  
Biological name :LBP
  
Synonyms : LBP / lipopolysaccharide binding protein / P18428
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q11.23
Gene start: 38346356
Gene end: 38377023
  
Corresponding Affymetrix probe sets: 211652_s_at (Human Genome U133 Plus 2.0 Array)   214461_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000217407
NCBI entrez gene - 3929     See in Manteia.
OMIM - 151990
RefSeq - NM_004139
RefSeq Peptide - NP_004130
swissprot - P18428
Ensembl - ENSG00000129988
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000006756Gallus gallus
 LbpENSMUSG00000016024Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BPI / P17213 / bactericidal/permeability-increasing proteinENSG0000010142544
PLTP / P55058 / phospholipid transfer proteinENSG0000010097924
BPIFC / Q8NFQ6 / BPI fold containing family CENSG0000018445923


Protein motifs (from Interpro)
Interpro ID Name
 IPR001124  Lipid-binding serum glycoprotein, C-terminal
 IPR017942  Lipid-binding serum glycoprotein, N-terminal
 IPR017943  Bactericidal permeability-increasing protein, alpha/beta domain superfamily
 IPR017954  Lipid-binding serum glycoprotein, conserved site
 IPR030180  Lipopolysaccharide-binding protein
 IPR030675  Lipid binding protein BPI/LBP
 IPR032942  BPI/LBP/Plunc family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002232 leukocyte chemotaxis involved in inflammatory response IEA
 biological_processGO:0002281 macrophage activation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006869 lipid transport IEA
 biological_processGO:0006953 acute-phase response ISS
 biological_processGO:0006968 cellular defense response ISS
 biological_processGO:0008228 opsonization ISS
 biological_processGO:0015920 lipopolysaccharide transport IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0032490 detection of molecule of bacterial origin IDA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IDA
 biological_processGO:0032722 positive regulation of chemokine production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IDA
 biological_processGO:0032757 positive regulation of interleukin-8 production IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0033036 macromolecule localization IDA
 biological_processGO:0034142 toll-like receptor 4 signaling pathway TAS
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IDA
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043032 positive regulation of macrophage activation IDA
 biological_processGO:0044130 negative regulation of growth of symbiont in host IEA
 biological_processGO:0045087 innate immune response ISS
 biological_processGO:0045919 positive regulation of cytolysis IDA
 biological_processGO:0050829 defense response to Gram-negative bacterium ISS
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0060265 positive regulation of respiratory burst involved in inflammatory response IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071223 cellular response to lipoteichoic acid IDA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space ISS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001530 lipopolysaccharide binding IDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0070891 lipoteichoic acid binding IDA
 molecular_functionGO:0071723 lipopeptide binding IDA


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade
Transfer of LPS from LBP carrier to CD14
Regulation of TLR by endogenous ligand
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / reaction






 

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