ENSG00000101425


Homo sapiens

Features
Gene ID: ENSG00000101425
  
Biological name :BPI
  
Synonyms : bactericidal/permeability-increasing protein / BPI / P17213
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q11.23
Gene start: 38304123
Gene end: 38337505
  
Corresponding Affymetrix probe sets: 205557_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000486976
Ensembl peptide - ENSP00000494528
Ensembl peptide - ENSP00000262865
Ensembl peptide - ENSP00000409833
NCBI entrez gene - 671     See in Manteia.
OMIM - 109195
RefSeq - NM_001725
RefSeq Peptide - NP_001716
swissprot - A0A0D9SFX6
swissprot - H0Y738
swissprot - P17213
Ensembl - ENSG00000101425
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000006756Gallus gallus
 BpiENSMUSG00000052922Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LBP / P18428 / lipopolysaccharide binding proteinENSG0000012998843
BPIFC / Q8NFQ6 / BPI fold containing family CENSG0000018445926
PLTP / P55058 / phospholipid transfer proteinENSG0000010097925


Protein motifs (from Interpro)
Interpro ID Name
 IPR001124  Lipid-binding serum glycoprotein, C-terminal
 IPR017942  Lipid-binding serum glycoprotein, N-terminal
 IPR017943  Bactericidal permeability-increasing protein, alpha/beta domain superfamily
 IPR017954  Lipid-binding serum glycoprotein, conserved site
 IPR030181  Bactericidal permeability-increasing protein
 IPR030675  Lipid binding protein BPI/LBP
 IPR032942  BPI/LBP/Plunc family


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0032715 negative regulation of interleukin-6 production IDA
 biological_processGO:0032717 negative regulation of interleukin-8 production IDA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IDA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043031 negative regulation of macrophage activation IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0001530 lipopolysaccharide binding IDA
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade
Neutrophil degranulation
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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