21898


Mus musculus (NCBI)
regulationresponseproductioninterleukin-processsignalingbiosyntheticreceptoractivationactivitypathwayfactormembranecelllipopolysaccharidebindingcellularimmuneinvolvedinflammatorytoll-likecytokineinterferon-gammatumornecrosiscascademacrophagesecretionstimuluserk

Features
Gene ID: 21898
  
Biological name :
  
Synonyms : Lps|Ly87|Ran/M1|Rasl2-8 / Tlr4 / toll-like receptor 4
  
Possible biological names infered from orthology :
  
Species: Mus musculus (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 1418162_at (Mouse Genome 430 2.0 Array)   1418163_at (Mouse Genome 430 2.0 Array)   1430695_at (Mouse Genome 430 2.0 Array)   1442827_at (Mouse Genome 430 2.0 Array)   
  
Cross references: RefSeq - 10946594
RefSeq - NC_000070.6
RefSeq - NP_067272.1
RefSeq - NM_021297.3
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSMUSG00000039005 to get all the annotations available for this gene.


Gene Ontology (GO)
nitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscell activationresponse to stressimmune responseimmune effector processleukocyte proliferationproduction of molecular mediator of immune responsecytokine productionsmall molecule metabolic processresponse to external stimulusresponse to biotic stimulusregulation of biological qualitycoagulationanatomical structure developmentcellular developmental processresponse to chemicaldetection of stimulusbiosynthetic processcell deathmacromolecule localizationestablishment of localizationsystem processresponse to abiotic stimulusdigestionresponse to endogenous stimuluscellular component organizationcellular component biogenesisnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscell activationresponse to stressimmune responseimmune effector processleukocyte proliferationproduction of molecular mediator of immune responsecytokine productionsmall molecule metabolic processresponse to external stimulusresponse to biotic stimulusregulation of biological qualitycoagulationanatomical structure developmentcellular developmental processresponse to chemicaldetection of stimulusbiosynthetic processcell deathmacromolecule localizationestablishment of localizationsystem processresponse to abiotic stimulusdigestionresponse to endogenous stimuluscellular component organizationcellular component biogenesisnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscell activationresponse to stressimmune responseimmune effector processleukocyte proliferationproduction of molecular mediator of immune responsecytokine productionsmall molecule metabolic processresponse to external stimulusresponse to biotic stimulusregulation of biological qualitycoagulationanatomical structure developmentcellular developmental processresponse to chemicaldetection of stimulusbiosynthetic processcell deathmacromolecule localizationestablishment of localizationsystem processresponse to abiotic stimulusdigestionresponse to endogenous stimuluscellular component organizationcellular component biogenesisnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscell activationresponse to stressimmune responseimmune effector processleukocyte proliferationproduction of molecular mediator of immune responsecytokine productionsmall molecule metabolic processresponse to external stimulusresponse to biotic stimulusregulation of biological qualitycoagulationanatomical structure developmentcellular developmental processresponse to chemicaldetection of stimulusbiosynthetic processcell deathmacromolecule localizationestablishment of localizationsystem processresponse to abiotic stimulusdigestionresponse to endogenous stimuluscellular component organizationcellular component biogenesisnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscell activationresponse to stressimmune responseimmune effector processleukocyte proliferationproduction of molecular mediator of immune responsecytokine productionsmall molecule metabolic processresponse to external stimulusresponse to biotic stimulusregulation of biological qualitycoagulationanatomical structure developmentcellular developmental processresponse to chemicaldetection of stimulusbiosynthetic processcell deathmacromolecule localizationestablishment of localizationsystem processresponse to abiotic stimulusdigestionresponse to endogenous stimuluscellular component organizationcellular component biogenesisnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscell activationresponse to stressimmune responseimmune effector processleukocyte proliferationproduction of molecular mediator of immune responsecytokine productionsmall molecule metabolic processresponse to external stimulusresponse to biotic stimulusregulation of biological qualitycoagulationanatomical structure developmentcellular developmental processresponse to chemicaldetection of stimulusbiosynthetic processcell deathmacromolecule localizationestablishment of localizationsystem processresponse to abiotic stimulusdigestionresponse to endogenous stimuluscellular component organizationcellular component biogenesisnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscell activationresponse to stressimmune responseimmune effector processleukocyte proliferationproduction of molecular mediator of immune responsecytokine productionsmall molecule metabolic processresponse to external stimulusresponse to biotic stimulusregulation of biological qualitycoagulationanatomical structure developmentcellular developmental processresponse to chemicaldetection of stimulusbiosynthetic processcell deathmacromolecule localizationestablishment of localizationsystem processresponse to abiotic stimulusdigestionresponse to endogenous stimuluscellular component organizationcellular component biogenesisnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscell activationresponse to stressimmune responseimmune effector processleukocyte proliferationproduction of molecular mediator of immune responsecytokine productionsmall molecule metabolic processresponse to external stimulusresponse to biotic stimulusregulation of biological qualitycoagulationanatomical structure developmentcellular developmental processresponse to chemicaldetection of stimulusbiosynthetic processcell deathmacromolecule localizationestablishment of localizationsystem processresponse to abiotic stimulusdigestionresponse to endogenous stimuluscellular component organizationcellular component biogenesisnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscell activationresponse to stressimmune responseimmune effector processleukocyte proliferationproduction of molecular mediator of immune responsecytokine productionsmall molecule metabolic processresponse to external stimulusresponse to biotic stimulusregulation of biological qualitycoagulationanatomical structure developmentcellular developmental processresponse to chemicaldetection of stimulusbiosynthetic processcell deathmacromolecule localizationestablishment of localizationsystem processresponse to abiotic stimulusdigestionresponse to endogenous stimuluscellular component organizationcellular component biogenesisnitrogen compound metabolic processcell communicationcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcellular response to stimuluscell activationresponse to stressimmune responseimmune effector processleukocyte proliferationproduction of molecular mediator of immune responsecytokine productionsmall molecule metabolic processresponse to external stimulusresponse to biotic stimulusregulation of biological qualitycoagulationanatomical structure developmentcellular developmental processresponse to chemicaldetection of stimulusbiosynthetic processcell deathmacromolecule localizationestablishment of localizationsystem processresponse to abiotic stimulusdigestionresponse to endogenous stimuluscellular component organizationcellular component biogenesisnitrnitrogen compound metabolic processcellcell communicationcellcellular metabolic processprimprimary metabolic processreguregulation of molecular functionorgaorganic substance metabolic processcellcellular response to stimuluscellcell activationrespresponse to stressimmuimmune responseimmuimmune effector processleukleukocyte proliferationprodproduction of molecular mediator of immune responsecytocytokine productionsmalsmall molecule metabolic processrespresponse to external stimulusrespresponse to biotic stimulusreguregulation of biological qualitycoagcoagulationanatanatomical structure developmentcellcellular developmental processrespresponse to chemicaldetedetection of stimulusbiosbiosynthetic processcellcell deathmacrmacromolecule localizationestaestablishment of localizationsystsystem processrespresponse to abiotic stimulusdigedigestionrespresponse to endogenous stimuluscellcellular component organizationcellcellular component biogenesis
lipid bindingcarbohydrate derivative bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingsignaling receptor activityprotein bindinglipid bindingcarbohydrate derivative bindingsignaling receptor activityprotein bindinglipid bindinglipid bindingcarbohydrate derivative bindingcarbohydrate derivative bindingsignaling receptor activitysignaling receptor activityprotein bindingprotein binding
cellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellorganellemembraneprotein-containing complexcellcellorganelleorganellemembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0001774 microglial cell activation ISO
 biological_processGO:0002218 activation of innate immune response IMP
 biological_processGO:0002224 toll-like receptor signaling pathway ISO
 biological_processGO:0002322 B cell proliferation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002537 nitric oxide production involved in inflammatory response IMP
 biological_processGO:0002730 regulation of dendritic cell cytokine production IDA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IGI
 biological_processGO:0002758 innate immune response-activating signal transduction ISO
 biological_processGO:0006691 leukotriene metabolic process ISO
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006979 response to oxidative stress ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007250 activation of NF-kappaB-inducing kinase activity NAS
 biological_processGO:0007252 I-kappaB phosphorylation ISO
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0010572 positive regulation of platelet activation IMP
 biological_processGO:0010628 positive regulation of gene expression ISO
 biological_processGO:0014002 astrocyte development IMP
 biological_processGO:0030890 positive regulation of B cell proliferation IMP
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway ISO
 biological_processGO:0032496 response to lipopolysaccharide ISO
 biological_processGO:0032497 detection of lipopolysaccharide TAS
 biological_processGO:0032609 interferon-gamma production IGI
 biological_processGO:0032689 negative regulation of interferon-gamma production IMP
 biological_processGO:0032700 negative regulation of interleukin-17 production IMP
 biological_processGO:0032707 negative regulation of interleukin-23 production IMP
 biological_processGO:0032715 negative regulation of interleukin-6 production IMP
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0032722 positive regulation of chemokine production ISO
 biological_processGO:0032727 positive regulation of interferon-alpha production IDA
 biological_processGO:0032728 positive regulation of interferon-beta production IDA
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0032732 positive regulation of interleukin-1 production IDA
 biological_processGO:0032733 positive regulation of interleukin-10 production IDA
 biological_processGO:0032735 positive regulation of interleukin-12 production IDA
 biological_processGO:0032755 positive regulation of interleukin-6 production NAS
 biological_processGO:0032757 positive regulation of interleukin-8 production ISO
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IMP
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IDA
 biological_processGO:0034142 toll-like receptor 4 signaling pathway IEA
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway IGI
 biological_processGO:0042116 macrophage activation ISS
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process ISO
 biological_processGO:0043032 positive regulation of macrophage activation IGI
 biological_processGO:0043065 positive regulation of apoptotic process ISO
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043388 positive regulation of DNA binding ISO
 biological_processGO:0045084 positive regulation of interleukin-12 biosynthetic process ISO
 biological_processGO:0045087 innate immune response TAS
 biological_processGO:0045348 positive regulation of MHC class II biosynthetic process IMP
 biological_processGO:0045359 positive regulation of interferon-beta biosynthetic process IMP
 biological_processGO:0045362 positive regulation of interleukin-1 biosynthetic process NAS
 biological_processGO:0045368 positive regulation of interleukin-13 biosynthetic process NAS
 biological_processGO:0045410 positive regulation of interleukin-6 biosynthetic process NAS
 biological_processGO:0045416 positive regulation of interleukin-8 biosynthetic process ISO
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IMP
 biological_processGO:0045471 response to ethanol ISO
 biological_processGO:0045576 mast cell activation NAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0046330 positive regulation of JNK cascade IGI
 biological_processGO:0050671 positive regulation of lymphocyte proliferation IMP
 biological_processGO:0050702 interleukin-1 beta secretion IDA
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion ISO
 biological_processGO:0050727 regulation of inflammatory response IMP
 biological_processGO:0050729 positive regulation of inflammatory response ISO
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0050829 defense response to Gram-negative bacterium IMP
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain ISO
 biological_processGO:0050966 detection of mechanical stimulus involved in sensory perception of pain ISO
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity ISO
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IDA
 biological_processGO:0051930 regulation of sensory perception of pain ISO
 biological_processGO:0060729 intestinal epithelial structure maintenance IMP
 biological_processGO:0060907 positive regulation of macrophage cytokine production IMP
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IMP
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0070430 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IDA
 biological_processGO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
 biological_processGO:0070542 response to fatty acid ISO
 biological_processGO:0071222 cellular response to lipopolysaccharide ISO
 biological_processGO:0071223 cellular response to lipoteichoic acid IMP
 biological_processGO:0071346 cellular response to interferon-gamma ISO
 biological_processGO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus IGI
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response IGI
 biological_processGO:1900227 positive regulation of NLRP3 inflammasome complex assembly IDA
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling ISO
 biological_processGO:1903223 positive regulation of oxidative stress-induced neuron death IGI
 biological_processGO:1903428 positive regulation of reactive oxygen species biosynthetic process IMP
 biological_processGO:1903974 positive regulation of cellular response to macrophage colony-stimulating factor stimulus ISO
 biological_processGO:1904467 regulation of tumor necrosis factor secretion ISO
 biological_processGO:1904646 cellular response to amyloid-beta ISO
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane ISO
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane ISO
 cellular_componentGO:0043235 receptor complex ISO
 cellular_componentGO:0045121 membrane raft ISO
 cellular_componentGO:0046696 lipopolysaccharide receptor complex ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0001530 lipopolysaccharide binding ISO
 molecular_functionGO:0001875 lipopolysaccharide receptor activity ISO
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding ISO
 molecular_functionGO:0046982 protein heterodimerization activity ISO


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   


© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr