ENSGALG00000005646


Gallus gallus

Features
Gene ID: ENSGALG00000005646
  
Biological name :TSC2
  
Synonyms : TSC2 / TSC complex subunit 2
  
Possible biological names infered from orthology : P49815 / tuberous sclerosis 2
  
Species: Gallus gallus
  
Chr. number: 14
Strand: 1
Band:
Gene start: 6306530
Gene end: 6335008
  
Corresponding Affymetrix probe sets: GgaAffx.3545.1.S1_at (Chicken Array)   GgaAffx.3545.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050606
Ensembl peptide - ENSGALP00000053919
Ensembl peptide - ENSGALP00000009042
NCBI entrez gene - 416552     See in Manteia.
RefSeq - XM_015294452
RefSeq - XM_015294449
RefSeq - XM_015294450
RefSeq - XM_015294451
RefSeq - XM_015294446
RefSeq - XM_015294447
RefSeq - XM_015294448
swissprot - A0A1D5PM46
swissprot - F1NGI4
swissprot - A0A1D5PCW5
Ensembl - ENSGALG00000005646
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TSC2ENSG00000103197Homo sapiens
 Tsc2ENSMUSG00000002496Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
RALGAPA1 / ral GTPase-activating protein subunit alpha-1 isoform 3 / Q6GYQ0* / Q6GYP7* / Ral GTPase activating protein, alpha subunit 1* / Ral GTPase activating protein catalytic alpha subunit 1*ENSGALG0000001008816
SIPA1L2 / signal induced proliferation associated 1 like 2 / Q80TE4* / Q9P2F8* / Mus musculus signal-induced proliferation-associated 1 like 2 (Sipa1l2), transcript variant 2, mRNA.*ENSGALG000000375069
SIPA1L1 / O43166* / Q8C0T5* / signal induced proliferation associated 1 like 1* / Signal-induced proliferation-associated 1-like protein 1 *ENSGALG000000093819
GARNL3 / GTPase-activating Rap/Ran-GAP domain-like protein 3 / Q3V0G7* / Q5VVW2* / GTPase activating Rap/RanGAP domain like 3* / Mus musculus GTPase activating RANGAP domain-like 3 (Garnl3...ENSGALG000000008475
A3KGS3* / Q2PPJ7* / RALGAPA2* / Ral GTPase-activating protein subunit alpha-2 * / Ral GTPase activating protein catalytic alpha subunit 2*ENSGALG000000447305
A3KGS3* / Q2PPJ7* / RALGAPA2* / Ral GTPase-activating protein subunit alpha-2 * / Ral GTPase activating protein catalytic alpha subunit 2*ENSGALG000000329644
RAP1GAP2 / rap1 GTPase-activating protein 2 / Q5SVL6* / Q684P5*ENSGALG000000338854
RAP1GAP1 / RAP1 GTPase activating protein / P47736* / A2ALS5* / RAP1GAP* / Mus musculus Rap1 GTPase-activating protein (Rap1gap), transcript variant 5, mRNA.*ENSGALG000000147013


Protein motifs (from Interpro)
Interpro ID Name
 IPR000331  Rap GTPase activating protein domain
 IPR003913  Tuberin
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR018515  Tuberin-type domain
 IPR024584  Tuberin, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016239 positive regulation of macroautophagy IEA
 biological_processGO:0030178 negative regulation of Wnt signaling pathway IBA
 biological_processGO:0032007 negative regulation of TOR signaling IEA
 biological_processGO:0043276 anoikis IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IBA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction IEA
 biological_processGO:0051726 regulation of cell cycle IBA
 biological_processGO:0051898 negative regulation of protein kinase B signaling IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0033596 TSC1-TSC2 complex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0019902 phosphatase binding IEA
 molecular_functionGO:0031267 small GTPase binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA


Pathways (from Reactome)
Pathway description
Macroautophagy
Inhibition of TSC complex formation by PKB
AKT phosphorylates targets in the cytosol
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
TBC/RABGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001678 PRKAB2 / protein kinase AMP-activated non-catalytic subunit beta 2 / O43741* / Q6PAM0* / protein kinase, AMP-activated, beta 2 non-catalytic subunit*  / reaction
 ENSGALG00000007373 PRKAB1 / Q9R078* / Q9Y478* / protein kinase AMP-activated non-catalytic subunit beta 1* / protein kinase, AMP-activated, beta 1 non-catalytic subunit*  / reaction
 ENSGALG00000005646 TSC2 / TSC complex subunit 2 / P49815* / tuberous sclerosis 2*  / complex
 ENSGALG00000014832 PRKAA1 / protein kinase AMP-activated catalytic subunit alpha 1 / Q13131* / Q5EG47* / protein kinase, AMP-activated, alpha 1 catalytic subunit*  / reaction
 ENSGALG00000010826 PRKAA2 / protein kinase AMP-activated catalytic subunit alpha 2 / P54646* / Q8BRK8* / protein kinase, AMP-activated, alpha 2 catalytic subunit*  / reaction
 ENSGALG00000011360 PRKAG3 / 5-AMP-activated protein kinase subunit gamma-3 / Q9UGI9* / Q8BGM7* / protein kinase AMP-activated non-catalytic subunit gamma 3* / protein kinase, AMP-activated, gamma 3 non-catat...  / reaction
 ENSGALG00000036282 O54950* / P54619* / PRKAG1* / protein kinase AMP-activated non-catalytic subunit gamma 1* / protein kinase, AMP-activated, gamma 1 non-catalytic subunit*  / reaction






 

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