ENSMUSG00000073982


Mus musculus

Features
Gene ID: ENSMUSG00000073982
  
Biological name :Rhog
  
Synonyms : P84096 / ras homolog family member G / Rhog
  
Possible biological names infered from orthology : P84095
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E2
Gene start: 102239123
Gene end: 102256054
  
Corresponding Affymetrix probe sets: 10566132 (MoGene1.0st)   1422572_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000147985
Ensembl peptide - ENSMUSP00000095832
Ensembl peptide - ENSMUSP00000102536
NCBI entrez gene - 56212     See in Manteia.
MGI - MGI:1928370
RefSeq - NM_019566
RefSeq Peptide - NP_062512
swissprot - A0A1B0GSL4
swissprot - P84096
swissprot - Q3UDZ1
Ensembl - ENSMUSG00000073982
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rhogaENSDARG00000068653Danio rerio
 rhogbENSDARG00000004301Danio rerio
 RHOGENSGALG00000026995Gallus gallus
 RHOGENSG00000177105Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*ENSMUSG0000000184772
Rac2 / Q05144 / Ras-related C3 botulinum toxin substrate 2 / P15153* / Rac family small GTPase 2*ENSMUSG0000003322072
Rac3 / P60764 / RAS-related C3 botulinum substrate 3 / P60763* / Rac family small GTPase 3*ENSMUSG0000001801270
Cdc42 / P60766 / Cell division control ENSMUSG0000000669961
Rhoq / Q8R527 / Rho-related GTP-binding protein RhoQ / P17081* / ras homolog family member Q*ENSMUSG0000002414354
Rhoj / Q9ER71 / ras homolog family member J / Q9H4E5*ENSMUSG0000004676852
Rhou / Q9EQT3 / Rho-related GTP-binding protein RhoU / Q7L0Q8* / ras homolog family member U*ENSMUSG0000003996050
Rhov / Q8VDU1 / Rho-related GTP-binding protein RhoV / Q96L33* / ras homolog family member V*ENSMUSG0000003422647
Q91V93 / Rhobtb2 / Rho-related BTB domain-containing protein 2 / Q9BYZ6* / Rho related BTB domain containing 2*ENSMUSG0000002207542
Q9DAK3 / Rhobtb1 / Rho-related BTB domain-containing protein 1 / O94844* / Rho related BTB domain containing 1*ENSMUSG0000001994441


Protein motifs (from Interpro)
Interpro ID Name
 IPR001806  Small GTPase superfamily
 IPR003578  Small GTPase superfamily, Rho type
 IPR005225  Small GTP-binding protein domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007266 Rho protein signal transduction ISO
 biological_processGO:0016601 Rac protein signal transduction ISO
 biological_processGO:0030036 actin cytoskeleton organization ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0060326 cell chemotaxis ISS
 biological_processGO:0090630 activation of GTPase activity ISO
 biological_processGO:1900027 regulation of ruffle assembly IDA
 biological_processGO:1903078 positive regulation of protein localization to plasma membrane ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
Rho GTPase cycle
G alpha (12/13) signalling events
RHO GTPases activate KTN1
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cited1tm1Dunw/Cited1+
Genetic Background: B6.129P2-Cited1tm1Dunw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / reaction
 ENSMUSG00000020611 Gna13 / P27601 / guanine nucleotide binding protein, alpha 13 / Q14344* / G protein subunit alpha 13*  / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / reaction
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction
 ENSMUSG00000040940 Q61210 / Arhgef1 / Rho guanine nucleotide exchange factor 1 / Q92888*  / reaction
 ENSMUSG00000074657 Kif5a / P33175 / Kinesin heavy chain isoform 5A / Q12840* / kinesin family member 5A*  / reaction / complex
 ENSMUSG00000024862 Klc2 / kinesin light chain 2 / Q9H0B6*  / complex / reaction






 

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