Manteia

ENSMUSG00000024862

Mus musculus

Features

Gene ID:	ENSMUSG00000024862

Biological name :	Klc2

Synonyms :	kinesin light chain 2 / Klc2

Possible biological names infered from orthology :	Q9H0B6

Species:	Mus musculus

Chr. number:	19
Strand:	-1
Band:	A
Gene start:	5107746
Gene end:	5118560

Corresponding Affymetrix probe sets:	10464932 (MoGene1.0st) 1418214_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000109357 Ensembl peptide - ENSMUSP00000122458 Ensembl peptide - ENSMUSP00000112262 Ensembl peptide - ENSMUSP00000025798 Ensembl peptide - ENSMUSP00000109356 NCBI entrez gene - 16594 See in Manteia. MGI - MGI:107953 RefSeq - XM_011248603 RefSeq - XM_017318070 RefSeq - NM_008451 RefSeq - XM_017318069 RefSeq Peptide - NP_032477 swissprot - Q91YS4 swissprot - D3Z5Y7 swissprot - D3YXZ3 Ensembl - ENSMUSG00000024862

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
KLC2	ENSG00000174996	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Klc4 / Q9DBS5 / Mus musculus kinesin light chain 4 (Klc4), transcript variant 2, mRNA. / Q9NSK0* / kinesin light chain 4*	ENSMUSG00000003546	70
Klc1 / kinesin light chain 1 isoform 1G / Q07866* / AL139300.1* / kinesin light chain 1*	ENSMUSG00000021288	68
Klc3 / Q91W40 / Kinesin light chain 3 / Q6P597*	ENSMUSG00000040714	49
Nphp3 / Q7TNH6 / Nephrocystin-3 / Q7Z494* / NPHP3-ACAD11* / NPHP3-ACAD11 readthrough (NMD candidate)*	ENSMUSG00000032558	25
Gm28305	ENSMUSG00000101152	3

Protein motifs (from Interpro)

Interpro ID	Name
IPR002151	Kinesin light chain
IPR011990	Tetratricopeptide-like helical domain superfamily
IPR013026	Tetratricopeptide repeat-containing domain
IPR015792	Kinesin light chain repeat
IPR019734	Tetratricopeptide repeat
IPR036388	Winged helix-like DNA-binding domain superfamily

Gene Ontology (GO)

Pathways (from Reactome)

Pathway description

MHC class II antigen presentation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0006358	absent pinna reflex	"complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Jam3^{tm1.1(KOMP)Vlcg}/Jam3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Jam3^{tm1.1(KOMP)Vlcg}/J
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Jam3^{tm1.1(KOMP)Vlcg}/Jam3^{tm1.1(KOMP)Vlcg} Genetic Background: C57BL/6N-Jam3^{tm1.1(KOMP)Vlcg}/J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000007815	Rhoa / Q9QUI0 / ras homolog family member A / P61586*	/ complex / reaction
ENSMUSG00000024862	Klc2 / kinesin light chain 2 / Q9H0B6*	/ complex / reaction
ENSMUSG00000001847	Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*	/ complex / reaction
ENSMUSG00000073982	Rhog / P84096 / ras homolog family member G / P84095*	/ reaction / complex
ENSMUSG00000074657	Kif5a / P33175 / Kinesin heavy chain isoform 5A / Q12840* / kinesin family member 5A*	/ complex / reaction

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr