ENSMUSG00000021288


Mus musculus

Features
Gene ID: ENSMUSG00000021288
  
Biological name :Klc1
  
Synonyms : kinesin light chain 1 isoform 1G / Klc1
  
Possible biological names infered from orthology : AL139300.1 / kinesin light chain 1 / Q07866
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F1
Gene start: 111758849
Gene end: 111807844
  
Corresponding Affymetrix probe sets: 10398727 (MoGene1.0st)   1417005_at (Mouse Genome 430 2.0 Array)   1428881_at (Mouse Genome 430 2.0 Array)   1448541_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113171
Ensembl peptide - ENSMUSP00000113997
Ensembl peptide - ENSMUSP00000120491
Ensembl peptide - ENSMUSP00000082004
Ensembl peptide - ENSMUSP00000113237
NCBI entrez gene - 16593     See in Manteia.
MGI - MGI:107978
RefSeq - XM_017314965
RefSeq - NM_001025361
RefSeq - NM_001025362
RefSeq - NM_001025363
RefSeq - NM_001081959
RefSeq - NM_008450
RefSeq - XM_006515492
RefSeq - XM_006515494
RefSeq - XM_006515495
RefSeq - XM_006515498
RefSeq - XM_006515499
RefSeq - XM_011244001
RefSeq - XM_017314963
RefSeq - XM_017314964
RefSeq - NM_001025358
RefSeq - NM_001025359
RefSeq - NM_001025360
RefSeq Peptide - NP_032476
RefSeq Peptide - NP_001020529
RefSeq Peptide - NP_001020530
RefSeq Peptide - NP_001020531
RefSeq Peptide - NP_001020532
RefSeq Peptide - NP_001020533
RefSeq Peptide - NP_001020534
RefSeq Peptide - NP_001075428
swissprot - Q7TNF4
swissprot - Q5UE59
swissprot - F6UYN4
swissprot - Q8CD76
swissprot - E9Q7C9
Ensembl - ENSMUSG00000021288
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klc1aENSDARG00000009796Danio rerio
 ENSGALG00000011528Gallus gallus
 AL139300.1ENSG00000256500Homo sapiens
 KLC1ENSG00000126214Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Klc2 / kinesin light chain 2 / Q9H0B6*ENSMUSG0000002486268
Klc4 / Q9DBS5 / Mus musculus kinesin light chain 4 (Klc4), transcript variant 2, mRNA. / Q9NSK0* / kinesin light chain 4*ENSMUSG0000000354667
Klc3 / Q91W40 / Kinesin light chain 3 / Q6P597*ENSMUSG0000004071448
Nphp3 / Q7TNH6 / Nephrocystin-3 / Q7Z494* / NPHP3-ACAD11* / NPHP3-ACAD11 readthrough (NMD candidate)*ENSMUSG0000003255827
Gm28305ENSMUSG000001011524


Protein motifs (from Interpro)
Interpro ID Name
 IPR002151  Kinesin light chain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR015792  Kinesin light chain repeat
 IPR019734  Tetratricopeptide repeat
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0035418 protein localization to synapse IEA
 cellular_componentGO:0005871 kinesin complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031982 vesicle IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0015631 tubulin binding IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
RHO GTPases activate KTN1
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Tlr3M2Btlr/Tlr3+
Genetic Background: C57BL/6J-Tlr3M2Btlr

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0003225 axonal dystrophy "axon degeneration resulting from inadequate or faulty metabolism" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Klc1tm1Gsn/Klc1tm1Gsn
Genetic Background: B6.129-Klc1tm1Gsn

 MP:0003329 amyloid beta deposits 
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0004250 tau protein deposits "formation of self-assembled tangles of paired helical filaments and straight filaments due to hyperphosphorylation of the tau protein; often seen in neuronal tissues of individuals with neurodegenerative disorders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klc1tm1Gsn/Klc1tm1Gsn
Genetic Background: B6.129-Klc1tm1Gsn

 MP:0004768 abnormal axonal transport "any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klc1tm1Gsn/Klc1tm1Gsn
Genetic Background: B6.129-Klc1tm1Gsn

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gabrg2tm2.1Geh/Gabrg2tm2.1Geh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Klc1tm1Gsn/Klc1tm1Gsn
Genetic Background: B6.129-Klc1tm1Gsn

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Klc1tm1Gsn/Klc1tm1Gsn
Genetic Background: B6.129-Klc1tm1Gsn

 MP:0008026 abnormal brain white matter morphology "any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klc1tm1Gsn/Klc1tm1Gsn
Genetic Background: B6.129-Klc1tm1Gsn

 MP:0008027 abnormal spinal cord white matter morphology "any structural anomaly of the regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Klc1tm1Gsn/Klc1tm1Gsn
Genetic Background: B6.129-Klc1tm1Gsn

 MP:0008546 abnormal vesicle-mediated transport "anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell" [GO:0016192]
Show

Allelic Composition: Foxo3mommeR1/Foxo3tm1.1Rdp,Tg(HBA1-Gfp)1Ew/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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