ENSG00000126214


Homo sapiens

Features
Gene ID: ENSG00000126214
  
Biological name :KLC1
  
Synonyms : kinesin light chain 1 / KLC1 / Q07866
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.33
Gene start: 103561896
Gene end: 103714249
  
Corresponding Affymetrix probe sets: 212877_at (Human Genome U133 Plus 2.0 Array)   212878_s_at (Human Genome U133 Plus 2.0 Array)   213656_s_at (Human Genome U133 Plus 2.0 Array)   232036_at (Human Genome U133 Plus 2.0 Array)   244196_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000441347
Ensembl peptide - ENSP00000246489
Ensembl peptide - ENSP00000334523
Ensembl peptide - ENSP00000334618
Ensembl peptide - ENSP00000341154
Ensembl peptide - ENSP00000369377
Ensembl peptide - ENSP00000374394
Ensembl peptide - ENSP00000412693
Ensembl peptide - ENSP00000414982
Ensembl peptide - ENSP00000442554
Ensembl peptide - ENSP00000450616
Ensembl peptide - ENSP00000450617
Ensembl peptide - ENSP00000450648
Ensembl peptide - ENSP00000450786
Ensembl peptide - ENSP00000451242
Ensembl peptide - ENSP00000451691
Ensembl peptide - ENSP00000451732
Ensembl peptide - ENSP00000452095
Ensembl peptide - ENSP00000452167
Ensembl peptide - ENSP00000452481
Ensembl peptide - ENSP00000452487
Ensembl peptide - ENSP00000488938
NCBI entrez gene - 3831     See in Manteia.
OMIM - 600025
RefSeq - NM_001130107
RefSeq - NM_182923
RefSeq - NM_005552
RefSeq Peptide - NP_005543
RefSeq Peptide - NP_891553
RefSeq Peptide - NP_001123579
swissprot - G5E9S8
swissprot - G3V3H3
swissprot - H0YG16
swissprot - H0YGB8
swissprot - H0YJK1
swissprot - H0YJL0
swissprot - H0YJT3
swissprot - H0YJU9
swissprot - G3V2P7
swissprot - G3V2E7
swissprot - F8W6L3
swissprot - Q07866
swissprot - G3V5R9
Ensembl - ENSG00000126214
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 klc1aENSDARG00000009796Danio rerio
 ENSGALG00000011528Gallus gallus
 Klc1ENSMUSG00000021288Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AL139300.1ENSG0000025650090
KLC4 / Q9NSK0 / kinesin light chain 4ENSG0000013717167
KLC2 / Q9H0B6 / kinesin light chain 2ENSG0000017499667
KLC3 / Q6P597 / kinesin light chain 3ENSG0000010489247
NPHP3 / Q7Z494 / nephrocystin 3ENSG0000011397127
NPHP3-ACAD11 / NPHP3-ACAD11 readthrough (NMD candidate)ENSG0000027481012


Protein motifs (from Interpro)
Interpro ID Name
 IPR002151  Kinesin light chain
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR015792  Kinesin light chain repeat
 IPR019734  Tetratricopeptide repeat
 IPR036388  Winged helix-like DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0007018 microtubule-based movement TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0035617 stress granule disassembly ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005871 kinesin complex IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0030426 growth cone ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003774 motor activity TAS
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
RHO GTPases activate KTN1
COPI-dependent Golgi-to-ER retrograde traffic
Kinesins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000126214 KLC1 / Q07866 / kinesin light chain 1  / complex / reaction
 ENSG00000155980 KIF5A / Q12840 / kinesin family member 5A  / complex / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / complex / reaction
 ENSG00000126777 KTN1 / Q86UP2 / kinectin 1  / complex / reaction
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / reaction / complex
 ENSG00000174996 KLC2 / Q9H0B6 / kinesin light chain 2  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000177105 RHOG / P84095 / ras homolog family member G  / reaction / complex






 

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