ENSMUSG00000026009


Mus musculus

Features
Gene ID: ENSMUSG00000026009
  
Biological name :Icos
  
Synonyms : Icos / Inducible T-cell costimulator / Q9WVS0
  
Possible biological names infered from orthology : Q9Y6W8
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C2
Gene start: 60977927
Gene end: 61000320
  
Corresponding Affymetrix probe sets: 10346799 (MoGene1.0st)   1421930_at (Mouse Genome 430 2.0 Array)   1421931_at (Mouse Genome 430 2.0 Array)   1436598_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027162
Ensembl peptide - ENSMUSP00000099891
NCBI entrez gene - 54167     See in Manteia.
MGI - MGI:1858745
RefSeq - XM_006496140
RefSeq - NM_017480
RefSeq - XM_006496138
RefSeq - XM_006496139
RefSeq Peptide - NP_059508
swissprot - Q9WVS0
swissprot - Q5SUZ7
swissprot - Q5SUZ8
Ensembl - ENSMUSG00000026009
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ICOSENSGALG00000008656Gallus gallus
 ICOSENSG00000163600Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR013106  Immunoglobulin V-set domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002517 T cell tolerance induction IEA
 biological_processGO:0031295 T cell costimulation IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
PIP3 activates AKT signaling
Costimulation by the CD28 family
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Icostm1Dgry/Icostm1Dgry
Genetic Background: B6.129P2-Icostm1Dgry

 MP:0000496 abnormal small intestine morphology "structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Abi2tm1Pen/Abi2+
Genetic Background: B6.Cg-Abi2tm1Pen

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1Dgry/Icostm1Dgry
Genetic Background: B6.129P2-Icostm1Dgry

Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Shr/Icostm1Shr
Genetic Background: Not Specified

Allelic Composition: Icostm1Dgry/Icostm1Dgry
Genetic Background: B6.129P2-Icostm1Dgry

Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: NOD.129S1-Icostm1Flv

 MP:0001807 decreased IgA "less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cd28tm1Mak/Cd28tm1Mak,Rc3h1san/Rc3h1+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6JSfdAnu

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Icostm1Shr/Icostm1Shr
Genetic Background: Not Specified

 MP:0002217 small lymph nodes "lymph nodes of decreased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icosltm1Cdon/Icosltm1Cdon
Genetic Background: involves: 129S6/SvEvTac

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Icostm1Shr/Icostm1Shr
Genetic Background: Not Specified

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1Tkan/Icostm1Tkan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1Dgry/Icostm1Dgry
Genetic Background: B6.129P2-Icostm1Dgry

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Icosltm1Cdon/Icosltm1Cdon
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Icostm1Shr/Icostm1Shr
Genetic Background: Not Specified

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1Shr/Icostm1Shr
Genetic Background: Not Specified

 MP:0002870 decreased insulin autoantibody level "reduced level of antibodies to insulin present in the sera" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: NOD.129S1-Icostm1Flv

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Tie1tm1Jpa/Tie1tm1Jpa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

Allelic Composition: Icostm1Flv/Icostm1Flv,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Icostm1Flv/Icostm1Flv,Tg(Cd4-Maf)6666Glm/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003726 decreased autoantibody level "reduced level of antibodies to self-antigens present in the sera" [acv:Alicia Valenzuela, Genetic Resources Curator, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: NOD.129S1-Icostm1Flv

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: NOD.129S1-Icostm1Flv

Allelic Composition: Icostm1Flv/Icos+
Genetic Background: NOD.129S1-Icostm1Flv

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: NOD.129S1-Icostm1Flv

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004942 abnormal B cell selection "anomaly in the process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival" [GO:0002339]
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Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: NOD.129S1-Icostm1Flv

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Dgry/Icostm1Dgry
Genetic Background: B6.129P2-Icostm1Dgry

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Shr/Icostm1Shr
Genetic Background: Not Specified

Allelic Composition: Icostm1Dgry/Icostm1Dgry
Genetic Background: B6.129P2-Icostm1Dgry

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008093 abnormal memory B cell number "anomaly in the number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin" [CL:0000787, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Dgry/Icostm1Dgry
Genetic Background: B6.129P2-Icostm1Dgry

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Dgry/Icostm1Dgry
Genetic Background: B6.129P2-Icostm1Dgry

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Dgry/Icostm1Dgry
Genetic Background: B6.129P2-Icostm1Dgry

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1Tkan/Icostm1Tkan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Icostm1Dgry/Icostm1Dgry
Genetic Background: B6.129P2-Icostm1Dgry

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1Shr/Icostm1Shr
Genetic Background: Not Specified

Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Shr/Icostm1Shr
Genetic Background: Not Specified

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Shr/Icostm1Shr
Genetic Background: Not Specified

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: NOD.129S1-Icostm1Flv

 MP:0008568 abnormal interleukin secretion "anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Icostm1Dgry/Icostm1Dgry
Genetic Background: B6.129P2-Icostm1Dgry

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Icostm1Tkan/Icostm1Tkan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008603 decreased circulating interleukin-4 level "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Icostm1Tkan/Icostm1Tkan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Icostm1Dgry/Icostm1Dgry
Genetic Background: B6.129P2-Icostm1Dgry

Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Icostm1Dgry/Icostm1Dgry
Genetic Background: B6.129P2-Icostm1Dgry

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Icostm1Flv/Icostm1Flv
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1Shr/Icostm1Shr
Genetic Background: Not Specified

 MP:0008897 decreased IgG2c level "less than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009058 decreased interleukin-21 secretion "reduction in the production or release of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd9tm1Mek/Cd9tm1Mek
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Icostm1.1Wks/Icostm1.1Wks
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009168 decreased pancreatic islet number "reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Icostm1Flv/Icos+
Genetic Background: NOD.129S1-Icostm1Flv

 MP:0010268 decreased lymphoma incidence "less than the expected number of neoplasms derived from lymphoid tissue in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Icostm1Flv/Icostm1Flv,Rc3h1san/Rc3h1+
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BL/6JSfdAnu

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Icostm1Tkan/Icostm1Tkan
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / reaction / complex
 ENSMUSG00000000732 Icosl / Q9JHJ8 / icos ligand / ICOSLG* / O75144* / FP565260.3* / inducible T cell costimulator ligand*  / reaction / complex






 

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