ENSGALG00000002922


Gallus gallus

Features
Gene ID: ENSGALG00000002922
  
Biological name :NOTCH2
  
Synonyms : NOTCH2
  
Possible biological names infered from orthology : Q04721
  
Species: Gallus gallus
  
Chr. number: 8
Strand: 1
Band:
Gene start: 4177695
Gene end: 4256719
  
Corresponding Affymetrix probe sets: Gga.10652.1.S1_at (Chicken Array)   Gga.14211.1.S1_at (Chicken Array)   Gga.14336.1.S1_at (Chicken Array)   Gga.18916.1.S1_at (Chicken Array)   Gga.4950.1.S1_at (Chicken Array)   GgaAffx.20944.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000039195
NCBI entrez gene - 374031     See in Manteia.
RefSeq - NM_001252033
RefSeq Peptide - NP_001238962
swissprot - F1P236
Ensembl - ENSGALG00000002922
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 notch2ENSDARG00000043130Danio rerio
 si:ch73-281k2.5ENSDARG00000104329Danio rerio
 NOTCH2ENSG00000134250Homo sapiens
 Notch2ENSMUSG00000027878Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NOTCH1 / P46531* / Q01705* / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain*ENSGALG0000000237554
JAG1 / jagged 1 / P78504* / Q9QXX0* / Protein jagged-1 *ENSGALG0000000902014
JAG2 / jagged 2 / Q9QYE5* / Q9Y219* / Protein jagged-2 *ENSGALG0000001169614
SNED1 / sushi, nidogen and EGF like domains 1 / Q8TER0*ENSGALG0000004359612
ENSGALG0000001618310
DLL1 / delta-like protein 1 precursor / O00548* / Q61483* / delta like canonical Notch ligand 1* / Delta-like protein 1 Dll1-soluble form Dll1-derived cell-associated form Dll1-intracellular form*ENSGALG000000111828
DLL4 / delta like canonical Notch ligand 4 / Q9JI71* / Q9NR61* / Delta-like protein 4 *ENSGALG000000085148
ENSGALG000000399976


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000800  Notch domain
 IPR001881  EGF-like calcium-binding domain
 IPR002110  Ankyrin repeat
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR010660  Notch, NOD domain
 IPR011656  Notch, NODP domain
 IPR013032  EGF-like, conserved site
 IPR016186  C-type lectin-like/link domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR020683  Ankyrin repeat-containing domain
 IPR022336  Neurogenic locus Notch 2
 IPR024600  Domain of unknown function DUF3454, notch


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003184 pulmonary valve morphogenesis IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045967 negative regulation of growth rate IEA
 biological_processGO:0046579 positive regulation of Ras protein signal transduction IEA
 biological_processGO:0046849 bone remodeling IEA
 biological_processGO:0050793 regulation of developmental process IEA
 biological_processGO:0060413 atrial septum morphogenesis IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:2001204 regulation of osteoclast development IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Pre-NOTCH Processing in Golgi
NOTCH2 intracellular domain regulates transcription
NOTCH2 Activation and Transmission of Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000008367 MDK / midkine precursor / P12025* / P21741* / midkine*  / complex / reaction
 ENSGALG00000009809 MAML3 / mastermind like transcriptional coactivator 3 / Q96JK9*  / reaction / complex
 ENSGALG00000017199 MAML2 / mastermind like transcriptional coactivator 2 / Q8IZL2* / mastermind-like protein 2 isoform 1 *  / reaction / complex
 ENSGALG00000002922 NOTCH2 / Q04721*  / complex






 

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