ENSMUSG00000034064


Mus musculus

Features
Gene ID: ENSMUSG00000034064
  
Biological name :Poglut1
  
Synonyms : Poglut1 / protein O-glucosyltransferase 1 / Q8BYB9
  
Possible biological names infered from orthology : Q8NBL1
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B4
Gene start: 38525137
Gene end: 38550258
  
Corresponding Affymetrix probe sets: 10439471 (MoGene1.0st)   1426535_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038166
NCBI entrez gene - 224143     See in Manteia.
MGI - MGI:2444232
RefSeq - NM_172380
RefSeq - NM_001300827
RefSeq Peptide - NP_001287756
RefSeq Peptide - NP_759012
swissprot - Q8BYB9
Ensembl - ENSMUSG00000034064
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 poglut1ENSDARG00000053463Danio rerio
 POGLUT1ENSGALG00000015480Gallus gallus
 Q8NBL1ENSG00000163389Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kdelc2 / KDEL motif containing 2 / Q7Z4H8*ENSMUSG0000003448728
Kdelc1 / Q9JHP7 / KDEL motif-containing protein 1 / Q6UW63* / KDEL motif containing 1*ENSMUSG0000002604728


Protein motifs (from Interpro)
Interpro ID Name
 IPR006598  Lipopolysaccharide-modifying protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0006486 protein glycosylation IEA
 biological_processGO:0006493 protein O-linked glycosylation IEA
 biological_processGO:0006664 glycolipid metabolic process IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0008593 regulation of Notch signaling pathway IMP
 biological_processGO:0010470 regulation of gastrulation IMP
 biological_processGO:0018242 protein O-linked glycosylation via serine IDA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IEA
 biological_processGO:0048318 axial mesoderm development IMP
 biological_processGO:0048339 paraxial mesoderm development IMP
 biological_processGO:0060537 muscle tissue development IEA
 biological_processGO:0072358 cardiovascular system development IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016757 transferase activity, transferring glycosyl groups IEA
 molecular_functionGO:0030158 protein xylosyltransferase activity IEA
 molecular_functionGO:0035251 UDP-glucosyltransferase activity TAS
 molecular_functionGO:0035252 UDP-xylosyltransferase activity IEA
 molecular_functionGO:0046527 glucosyltransferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
Show

Allelic Composition: Npm1tm1Gsva/Npm1tm1Gsva,Dppa3tm1(cre)Peli/Dppa3+
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Npm1tm1Gsva/Npm1tm1Gsva,Dppa3tm1(cre)Peli/Dppa3+
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npm1tm1Gsva/Npm1tm1Gsva,Dppa3tm1(cre)Peli/Dppa3+
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npm1tm1Gsva/Npm1tm1Gsva,Dppa3tm1(cre)Peli/Dppa3+
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Smobnb/Smobnb
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Npm1tm1Gsva/Npm1tm1Gsva,Dppa3tm1(cre)Peli/Dppa3+
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
Show

Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

 MP:0004187 cardia bifida "failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts" [smb:Susan M Bello, Mouse Genome Informatics Curator ""]
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Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

 MP:0004837 abnormal neural fold formation "any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

 MP:0005083 abnormal biliary tract morphology "anomalous structure or development of the gall bladder or its ducts " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
Show

Allelic Composition: Smobnb/Smobnb
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

 MP:0006386 absent somites "missing all somites" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smobnb/Smobnb
Genetic Background: involves: C3H/HeJ * C57BL/6J

Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

 MP:0012183 decreased paraxial mesoderm size "reduced size or deficiency of the mesoderm lying at either side of the midline embryonic notochord that, on segmentation, forms the paired somites" [MGI:anna]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

Allelic Composition: Poglut1wsnp/Poglut1wsnp
Genetic Background: involves: C3H/HeJ * C57BL/6J

 MP:0012254 absent intersomitic vessels "absence of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna]
Show

Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

 MP:0012272 decreased axial mesoderm size "reduced size or deficiency of the part of the middle of the three primary germ layers of the embryo which includes the prechordal mesoderm and the chordamesoderm and gives rise to the prechordal plate and to the notochord" [MGI:anna]
Show

Allelic Composition: Ugdhlzme/Ugdhlzme
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0012498 abnormal cardiogenic plate morphology "any structural anomaly of the splanchnic mesodermal thickening which forms cranial and lateral to the developing neural plate; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube" [MGI:anna]
Show

Allelic Composition: Poglut1Gt(IST10323G11)Tigm/Poglut1Gt(IST10323G11)Tigm
Genetic Background: involves: C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026923 Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*  / reaction






 

1 s.

 
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