ENSDARG00000004870


Danio rerio

Features
Gene ID: ENSDARG00000004870
  
Biological name :psen1
  
Synonyms : presenilin 1 / psen1
  
Possible biological names infered from orthology : P49768 / P49769
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 51206225
Gene end: 51224800
  
Corresponding Affymetrix probe sets: Dr.14679.1.A1_s_at (Zebrafish Array)   Dr.14679.1.A1_x_at (Zebrafish Array)   Dr.8310.1.S1_at (Zebrafish Array)   NM_131024_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000124467
Ensembl peptide - ENSDARP00000124616
Ensembl peptide - ENSDARP00000136264
Ensembl peptide - ENSDARP00000146226
NCBI entrez gene - 30221     See in Manteia.
RefSeq - NM_131024
RefSeq - XM_005169882
RefSeq - XM_005169883
RefSeq Peptide - NP_571099
swissprot - F8W2T3
swissprot - F1Q8Y6
swissprot - F8W381
ZFIN ID - ZDB-GENE-991119-4
Ensembl - ENSDARG00000004870
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSEN1ENSGALG00000009320Gallus gallus
 PSEN1ENSG00000080815Homo sapiens
 Psen1ENSMUSG00000019969Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
psen2 / Q90ZE4 / presenilin 2 / P49810*ENSDARG0000001554061


Protein motifs (from Interpro)
Interpro ID Name
 IPR001108  Peptidase A22A, presenilin
 IPR002031  Peptidase A22A, presenilin 1
 IPR006639  Presenilin/signal peptide peptidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0016485 protein processing IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004190 aspartic-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation
NOTCH3 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000006 ball ball increased size , abnormal
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 ZFA:0000008 brain brain hydrocephalic , abnormal
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 ZFA:0000029 hindbrain hindbrain hydrocephalic , abnormal
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 ZFA:0000075 spinal cord spinal cord decreased thickness , abnormal
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 ZFA:0000106 extension extension decreased size , abnormal
extension aplastic , abnormal
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 ZFA:0000110 fourth ventricle fourth ventricle increased size , abnormal
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 ZFA:0000128 midbrain midbrain hydrocephalic , abnormal
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 ZFA:0000155 somite somite shape , abnormal
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 ZFA:0000159 tectal ventricle tectal ventricle increased size , abnormal
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 ZFA:0001071 presumptive neural retina presumptive neural retina molecular quality , abnormal
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 ZFA:0001094 whole organism whole organism decreased size , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001115 trunk trunk melanocyte decreased amount , abnormal
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 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region melanocyte decreased amount , abnormal
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 ZFA:0005110 thoracic duct thoracic duct absent , abnormal
thoracic duct wholeness , abnormal
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 ZFA:0005178 DoLA DoLA increased amount , abnormal
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 ZFA:0009091 melanocyte melanocyte spatial pattern , abnormal
melanocyte decreased amount , abnormal
melanocyte decreased size , abnormal
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 ZFA:0009165 neural crest cell neural crest cell decreased amount , abnormal
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 ZFA:0009248 neuron neuron increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005612 aph1b / Q8JHE9 / APH1B gamma secretase subunit / Aph1c* / Q9DCZ9* / Q8C7N7* / Q8WW43* / Gamma-secretase subunit APH-1B * / Putative gamma-secretase subunit APH-1C * / aph-1 homolog B, gamma...  / complex
 ENSDARG00000068698 psenen / Q8JHF0 / presenilin enhancer gamma secretase subunit / Q9NZ42* / Q9CQR7* / AD000671.1* / Gamma-secretase subunit PEN-2 *  / complex
 ENSDARG00000004870 psen1 / presenilin 1 / P49768* / P49769*  / complex
 ENSDARG00000088708 ngfra / nerve growth factor receptor a (TNFR superfamily, member 16) / NGFR* / P08138* / nerve growth factor receptor*  / reaction
 ENSDARG00000089223 ngfrb / nerve growth factor receptor b / NGFR* / P08138* / nerve growth factor receptor*  / reaction






 

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