ENSMUSG00000057722


Mus musculus

Features
Gene ID: ENSMUSG00000057722
  
Biological name :Lepr
  
Synonyms : Lepr / Leptin receptor / P48356
  
Possible biological names infered from orthology : P48357
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C6
Gene start: 101717404
Gene end: 101815352
  
Corresponding Affymetrix probe sets: 10506301 (MoGene1.0st)   1425644_at (Mouse Genome 430 2.0 Array)   1425873_a_at (Mouse Genome 430 2.0 Array)   1425875_a_at (Mouse Genome 430 2.0 Array)   1456156_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037385
Ensembl peptide - ENSMUSP00000099838
Ensembl peptide - ENSMUSP00000102534
Ensembl peptide - ENSMUSP00000123654
NCBI entrez gene - 16847     See in Manteia.
MGI - MGI:104993
RefSeq - XM_017320002
RefSeq - NM_001122899
RefSeq - NM_010704
RefSeq - NM_146146
RefSeq Peptide - NP_001116371
RefSeq Peptide - NP_034834
RefSeq Peptide - NP_666258
swissprot - P48356
swissprot - Q3UNU8
swissprot - Q3US58
swissprot - A2AV66
Ensembl - ENSMUSG00000057722
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 leprENSDARG00000070961Danio rerio
 LEPRENSGALG00000011058Gallus gallus
 LEPRENSG00000116678Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003529  Long hematopoietin receptor, Gp130 family 2, conserved site
 IPR003531  Short hematopoietin receptor, family 1, conserved site
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR010457  Immunoglobulin C2-set-like, ligand-binding
 IPR013783  Immunoglobulin-like fold
 IPR015752  Leptin receptor
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006909 phagocytosis IMP
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008203 cholesterol metabolic process IGI
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0019222 regulation of metabolic process TAS
 biological_processGO:0019953 sexual reproduction IMP
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0033210 leptin-mediated signaling pathway IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0044321 response to leptin IMP
 biological_processGO:0045721 negative regulation of gluconeogenesis IMP
 biological_processGO:0046850 regulation of bone remodeling IMP
 biological_processGO:0051346 negative regulation of hydrolase activity IGI
 biological_processGO:0060259 regulation of feeding behavior IMP
 biological_processGO:0097009 energy homeostasis IMP
 biological_processGO:0098868 bone growth IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0038021 leptin receptor activity IMP
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000003 abnormal adipose tissue morphology "structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Leprdb/Leprdb,Tg(SHBG)4-aGlha/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Lepr+,Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic Background: involves: C3H * C57BL/6 * C57BLKS/J

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: FVB.BKS-Leprdb

Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: B6.129-Leprdb-3J

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLt-Leprdb-5J

Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL

 MP:0000259 abnormal vascular development "malformation or aberrant differentiation of the blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17509]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Xdhrenf/Xdhrenf
Genetic Background: involves: C3H * C57BL/6J

 MP:0000642 enlarged adrenal glands "increased size of the endocrine gland" [J:40203]
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Allelic Composition: Kcna1tm1Tem/Kcna1tm1Tem
Genetic Background: involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ

 MP:0000643 absent central medulla "missing marrow like structure; cells here are responsible for secretion of epinephrine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Kcna1tm1Tem/Kcna1tm1Tem
Genetic Background: involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL

Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0001119 abnormal female reproductive anatomy "anomalous structure of the organs associated with producing offspring in the gender that bears the offspring" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

 MP:0001120 abnormal uterus morphology "malformation or absence of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: T24H/T+,th2/t+
Genetic Background: involves: 101/H * C3H/HeH

 MP:0001143 constricted vaginal opening "shrunken, narrowed external vaginal opening" [J:50844]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb-2J/Leprdb-2J
Genetic Background: involves: C57BL/6J * STOCK Tyrp1b Whrnwi

 MP:0001157 small seminal gland "reduced size, compared to the norm, of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Zfxtm1Dcp/Zfxtm1Dcp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Leprdb-1R/Leprdb-1R
Genetic Background: involves: D7R75M

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)7Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Dbsq2C3H/HeJ/Dbsq2C3H/HeJ,Leprdb/Lepr+
Genetic Background: involves: C3H/HeJ * C57BLKS

Allelic Composition: Dbsq2C57BLKS/J/Dbsq2C3H/HeJ,Leprdb/Lepr+
Genetic Background: involves: C3H/HeJ * C57BLKS

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprtm1Mgmj/Lepr+
Genetic Background: B6.129-Leprtm1Mgmj

Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: LeprKK/LeprKK
Genetic Background: involves: C57BL/6J * KK/HlLt

Allelic Composition: Leprdb/Lepr+
Genetic Background: involves: C57BLKS/J

Allelic Composition: LeprDb-Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-Btlr

Allelic Composition: LeprDb-2Btlr/Lepr+
Genetic Background: C57BL/6J-LeprDb-2Btlr

Allelic Composition: Leprdb-ad/Leprdb-ad
Genetic Background: Not Specified

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

Allelic Composition: Leprm4Btlr/?
Genetic Background: C57BL/6J-Leprm4Btlr

Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

Allelic Composition: Leprdb/Leprdb,Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BLKS/J * DBA

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6 * CBA

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Leprtm5Mgmj/Leprtm5Mgmj
Genetic Background: B6.129-Leprtm5Mgmj

Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

Allelic Composition: Leprm6Btlr/Leprm6Btlr
Genetic Background: C57BL/6J-Leprm6Btlr

Allelic Composition: Leprm6Btlr/Lepr+
Genetic Background: C57BL/6J-Leprm6Btlr

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Leprtm5Mgmj/Leprtm5Mgmj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Leprtm1.1Rck/Leprtm1.1Rck
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Leprdb-1R/Leprdb-1R
Genetic Background: involves: D7R75M

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLtJ

Allelic Composition: Leprdb-rtnd/Leprdb-rtnd
Genetic Background: involves: C57BL/6 * CBA/J

Allelic Composition: Leprdb-rlpy/Leprdb-rlpy
Genetic Background: NU/J

Allelic Composition: Leprdb-dmpg/Leprdb-dmpg
Genetic Background: involves: B10.D2-H8b/Sn * C57BL/6

Allelic Composition: Leprtm1Chua/Leprtm1Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6J * FVB/N

Allelic Composition: Leprdb/Leprdb
Genetic Background: FVB.BKS-Leprdb

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb-5J
Genetic Background: involves: C57BLKS/J * NOD/ShiLtJ

Allelic Composition: LeprKK/LeprKK
Genetic Background: involves: C57BL/6J * KK/HlLt

Allelic Composition: LeprDb-Btlr/LeprDb-Btlr
Genetic Background: C57BL/6J-LeprDb-Btlr

Allelic Composition: LeprDb-2Btlr/LeprDb-2Btlr
Genetic Background: C57BL/6J-LeprDb-2Btlr

Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

Allelic Composition: Leprdb-NCSU/Leprdb-NCSU
Genetic Background: involves: CD-1

Allelic Composition: Leprm3Btlr/Leprm3Btlr
Genetic Background: C57BL/6J-Leprm3Btlr

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

Allelic Composition: Leprbrta/Leprbrta
Genetic Background: C57BL/6JSfdAnu-Leprbrta/Anu

Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

Allelic Composition: Leprdb-lb/Leprdb-lb
Genetic Background: C57BL/6NCrl-Leprdb-lb/Crl

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Leprm1Anu/Leprm1Anu
Genetic Background: C57BL/6JAnu-Leprm1Anu

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch,Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Leprm1Clo/Leprm1Clo
Genetic Background: STOCK Leprm1Clo/GrsrJ

Allelic Composition: Leprdb/Leprdb,Tg(SHBG)4-aGlha/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Sirt1tm1.1Ygu/Sirt1tm1.1Ygu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Leprdb/Leprdb,Tg(Fabp4-Fcor)1Jnak/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * DBA/2

Allelic Composition: Leprdb/Leprdb,Repin1tm1.2Arte/Repin1tm1.2Arte
Genetic Background: involves: BALB/c * C57BL/6 * C57BLKS/J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLt-Leprdb-5J

 MP:0001264 increased body size "larger than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Kcna1tm1Tem/Kcna1tm1Tem
Genetic Background: involves: 129S7SvEvBrd * BALB/cByJ * C3HeB/FeJ

Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

 MP:0001272 increased metastatic potential 
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Afg3l2Emv66/Afg3l2Emv66
Genetic Background: FVB.MEV2-Afg3l2Emv66

 MP:0001380 male reduced copulation without impotence "males do not initiate sexual behavior as scored by the presence of copulation plugs (not due to infertility)" [J:57125]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb-2J/Leprdb-2J
Genetic Background: involves: C57BL/6J * STOCK Tyrp1b Whrnwi

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb-NCSU/Leprdb-NCSU
Genetic Background: involves: CD-1

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Relnrl-8J/Relnrl-8J
Genetic Background: STOCK Relnrl-8J/J

Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

Allelic Composition: Leprtm5Mgmj/Leprtm5Mgmj
Genetic Background: B6.129-Leprtm5Mgmj

Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zfxtm1Dcp/Zfxtm1Dcp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Leprtm1Chua/Leprtm1Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLt-Leprdb-5J

Allelic Composition: Leprdb-NCSU/Leprdb-NCSU
Genetic Background: involves: CD-1

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Pdgfratm6Sor/Pdgfratm11(EGFP)Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dach1tm1Mrd/Dach1tm1Mrd
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb-lb/Leprdb-lb
Genetic Background: C57BL/6NCrl-Leprdb-lb/Crl

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Leprdb/Leprdb,Tg(SHBG)4-aGlha/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Leprdb/Leprdb,Tg(SHBG)4-aGlha/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Leprtm1Rck/Leprtm1.1Rck,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLtJ

Allelic Composition: Leprdb-rtnd/Leprdb-rtnd
Genetic Background: involves: C57BL/6 * CBA/J

Allelic Composition: Leprdb-rlpy/Leprdb-rlpy
Genetic Background: NU/J

Allelic Composition: Leprdb-dmpg/Leprdb-dmpg
Genetic Background: involves: B10.D2-H8b/Sn * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: FVB.BKS-Leprdb

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLt-Leprdb-5J

Allelic Composition: Leprdb-9J/Leprdb-9J
Genetic Background: involves: C57BL/6 * CBA * SWR

Allelic Composition: LeprDb-Btlr/LeprDb-Btlr
Genetic Background: C57BL/6J-LeprDb-Btlr

Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprbrta/Leprbrta
Genetic Background: C57BL/6JSfdAnu-Leprbrta/Anu

Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/Jcl

Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Leprdb/Leprdb,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J

Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

Allelic Composition: Leprdb/Leprdb,Tg(SHBG)4-aGlha/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: B6.129-Leprdb-3J

Allelic Composition: Leprdb/Lepr+
Genetic Background: involves: C57BLKS/J

 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Lepr+
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Lepr+
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Leprdb-NCSU/Leprdb-NCSU
Genetic Background: involves: CD-1

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb-ad/Leprdb-ad
Genetic Background: Not Specified

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0001777 abnormal body temperature regulation "anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacna1ftm1.2Sdie/Y
Genetic Background: B6(Cg)-Cacna1ftm1.2Sdie/J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0001868 ovary inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the ovary" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLt-Leprdb-5J

 MP:0001882 abnormal lactation "atypical production of milk from the mammary gland" [J:51296]
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Allelic Composition: Zfxtm1Dcp/Zfxtm1Dcp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0001899 absent long term depression "lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [Principles of Neural Science:ISBN 0-8385-8034-3, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Leprm1Clo/Leprm1Clo
Genetic Background: STOCK Leprm1Clo/GrsrJ

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

Allelic Composition: Leprdb-9J/Leprdb-9J
Genetic Background: involves: C57BL/6 * CBA * SWR

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Leprtm1Chua/Leprtm1Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

Allelic Composition: LeprDb-Btlr/LeprDb-Btlr
Genetic Background: C57BL/6J-LeprDb-Btlr

Allelic Composition: LeprDb-2Btlr/LeprDb-2Btlr
Genetic Background: C57BL/6J-LeprDb-2Btlr

Allelic Composition: Leprm3Btlr/Leprm3Btlr
Genetic Background: C57BL/6J-Leprm3Btlr

Allelic Composition: Leprbrta/Leprbrta
Genetic Background: C57BL/6JSfdAnu-Leprbrta/Anu

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Leprdb-NCSU/Leprdb-NCSU
Genetic Background: involves: CD-1

Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb-2J/Leprdb-2J
Genetic Background: involves: C57BL/6J * STOCK Tyrp1b Whrnwi

Allelic Composition: Leprdb-NCSU/Leprdb-NCSU
Genetic Background: involves: CD-1

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: involves: 129/Sv

Allelic Composition: Leprm1Clo/Leprm1Clo
Genetic Background: STOCK Leprm1Clo/GrsrJ

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Leprtm5Mgmj/Leprtm5Mgmj
Genetic Background: B6.129-Leprtm5Mgmj

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdgfratm6Sor/Pdgfratm11(EGFP)Sor
Genetic Background: either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6J)

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Zfxtm1Dcp/Zfxtm1Dcp
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Leprtm1Chua/Leprtm1Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: B6.129-Leprdb-3J

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Lepr+
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: KitlSl-38H/KitlSl-38H
Genetic Background: involves: BALB/c * C3H/HeN

Allelic Composition: Leprtm1Rck/Leprtm1.1Rck,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLtJ

Allelic Composition: Leprdb-rtnd/Leprdb-rtnd
Genetic Background: involves: C57BL/6 * CBA/J

Allelic Composition: Leprdb-rlpy/Leprdb-rlpy
Genetic Background: NU/J

Allelic Composition: Leprdb-dmpg/Leprdb-dmpg
Genetic Background: involves: B10.D2-H8b/Sn * C57BL/6

Allelic Composition: Leprtm1Chua/Leprtm1Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: FVB.BKS-Leprdb

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLt-Leprdb-5J

Allelic Composition: LeprKK/LeprKK
Genetic Background: involves: C57BL/6J * KK/HlLt

Allelic Composition: Leprdb-ad/Leprdb-ad
Genetic Background: Not Specified

Allelic Composition: Leprdb-NCSU/Leprdb-NCSU
Genetic Background: involves: CD-1

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/Jcl

Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Leprdb/Leprdb,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac,Leprdb/Leprdb
Genetic Background: B6.Cg-Foxo1tm2.1Dac Leprdb

Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Leprdb/Lepr+,Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic Background: involves: C3H * C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Leprdb/Leprdb,Tg(SHBG)4-aGlha/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dad1tm1Kni/Dad1+
Genetic Background: involves: 129S/SvEv

Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLt-Leprdb-5J

Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

Allelic Composition: Leprdb-NCSU/Leprdb-NCSU
Genetic Background: involves: CD-1

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atxn7tm1Hzo/Atxn7+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Airetm1.1Doi/Airetm1.1Doi,Tg(Ins2-TFRC/OVA)296Wehi/0,Tg(TcraTcrb)425Cbn/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nf1tm1Fcr/Nf1tm1.1Par
Genetic Background: involves: 129S/SvEv * 129S1/Sv * 129S2/SvPas * 129X1/SvJ

Allelic Composition: Leprtm1Rck/Leprtm1Rck
Genetic Background: involves: 129/Sv

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0002206 abnormal CNS synaptic transmission "defect in the communication from a neuron to a target across a synapse in the central nervous system" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Gt(ROSA)26Sortm2Sho/Gt(ROSA)26Sor+,Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002306 abnormal functional residual capacity "anomaly in the volume of air remaining in the lungs at the end of a normal expiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0002314 abnormal respiratory mechanics "anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0002333 abnormal lung compliance "anomalous pulmonary volume change per unit pressure change " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm,Tg(Tek-cre)12Flv/?
Genetic Background: involves: C3H * C57BL/6

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLt-Leprdb-5J

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: ItgaxM1Btlr/Itgax+
Genetic Background: C57BL/6J-ItgaxM1Btlr

 MP:0002498 abnormal acute inflammation "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1Rck/Leprtm1.1Rck,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Leprdb-9J/Leprdb-9J
Genetic Background: involves: C57BL/6 * CBA * SWR

Allelic Composition: Leprdb-lb/Leprdb-lb
Genetic Background: C57BL/6NCrl-Leprdb-lb/Crl

Allelic Composition: Leprm1Clo/Leprm1Clo
Genetic Background: STOCK Leprm1Clo/GrsrJ

Allelic Composition: Leprdb/Leprdb,Tg(SHBG)4-aGlha/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

 MP:0002637 small uterus "reduced size of the female muscular organ of gestation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb-2J/Leprdb-2J
Genetic Background: involves: C57BL/6J * STOCK Tyrp1b Whrnwi

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002680 decreased number of corpora lutea "fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrus cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb-9J/Leprdb-9J
Genetic Background: involves: C57BL/6 * CBA * SWR

 MP:0002682 reduced number of mature ovarian follicles "fewer than normal numbers of spehroidal cell aggregations in the ovary containing the ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb-9J/Leprdb-9J
Genetic Background: involves: C57BL/6 * CBA * SWR

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/Jcl

 MP:0002710 increased glucagon secretion "greater than normal release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0002712 increased circulating glucagon level "greater than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002716 small preputial glands "reduced size of the sebaceous glands of the corona and neck of the glans penis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, il:Ira Lu , Mouse Genome Informatics Curator, J:82312]
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Allelic Composition: Leprdb-2J/Leprdb-2J
Genetic Background: involves: C57BL/6J * STOCK Tyrp1b Whrnwi

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprtm2Mgmj/Leprtm2Mgmj
Genetic Background: B6.Cg-Leprtm2Mgmj

Allelic Composition: Leprtm2Mgmj/Lepr+
Genetic Background: B6.Cg-Leprtm2Mgmj

Allelic Composition: Leprdb-9J/Leprdb-9J
Genetic Background: involves: C57BL/6 * CBA * SWR

Allelic Composition: Leprdb/Lepr+
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002781 increased circulating testosterone level "greater than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb,Tg(SHBG)4-aGlha/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Afg3l2Emv66/Afg3l2Emv66
Genetic Background: FVB.MEV2-Afg3l2Emv66

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0002843 decreased blood pressure "decreased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: B6.129-Leprdb-3J

Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Leprdb/Leprdb,Tg(Fabp4-Fcor)1Jnak/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * DBA/2

Allelic Composition: Leprdb/Leprdb,Repin1tm1.2Arte/Repin1tm1.2Arte
Genetic Background: involves: BALB/c * C57BL/6 * C57BLKS/J

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+,Tg(Pomc1-hrGFP)1Lowl/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6 * CBA

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

Allelic Composition: Leprdb/Leprdb,Tg(SHBG)4-aGlha/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0003025 increased vascular smooth muscle contraction "greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Adrb2tm1Kry/Adrb2+,Lepob/Lep+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: C57BL/6 * FVB * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Leprdb/Leprdb,Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BLKS/J * DBA

Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Adrb2tm1Kry/Adrb2+,Lepob/Lep+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: C57BL/6 * FVB * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0003212 susceptibility to age related obesity "increased probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Leprtm3.1Yli/Lepr+
Genetic Background: B6.129-Leprtm3.1Yli

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

 MP:0003213 resistance to age related obesity "reduced probability of excessive weight gain that is progressive with age" [RGD:Rat Genome Database submission]
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Allelic Composition: Leprdb/Leprdb,Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0003355 reduced ovulation "reduction in the frequency in which an ovum is released from a rupturing ovarian follicle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0003443 increased circulating glycerol level "higher than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm5Mgmj/Leprtm5Mgmj
Genetic Background: B6.129-Leprtm5Mgmj

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: FVB.BKS-Leprdb

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Lepr+
Genetic Background: involves: C57BLKS/J

 MP:0003819 increased left ventricle diastolic pressure "increase in the pressure in the left ventricle between heart beats when the heart is relaxed" [RGD:Rat Genome Database submission]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0003881 abnormal nephron morphology "malformation of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of henle" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:71588]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

Allelic Composition: Leprdb/Leprdb,Tg(SHBG)4-aGlha/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Lepr+
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb-2J/Leprdb-2J
Genetic Background: involves: C57BL/6J * STOCK Tyrp1b Whrnwi

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0004120 cardiac ischemia "inadequate blood blow to the heart; may cause infarction and is usually caused by coronary artery disease" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0004183 abnormal sympathetic nervous system physiology "anomaly in the function of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Adrb2tm1Kry/Adrb2+,Lepob/Lep+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: C57BL/6 * FVB * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0004193 abnormal kidney papilla morphology "any structural anomaly of the apex of the renal pyramid that projects into a calyx" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0004195 abnormal calyx morphology "any structural anomaly of any of the branches of the renal pelvis that surround each renal papilla and collect urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0004232 decreased muscle weight "less than average muscle weight" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

 MP:0004260 enlarged placenta "increased size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Lepr+
Genetic Background: involves: C57BLKS/J

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb-lb/Leprdb-lb
Genetic Background: C57BL/6NCrl-Leprdb-lb/Crl

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0004896 abnormal endometrium morphology "any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy" [MESH:A05.360.319.679.490, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0004905 decreased uterus weight "reduction in the weight of the female organ of gestation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0004953 decreased spleen weight "reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLt-Leprdb-5J

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53tm1.2Awbr/Trp53+
Genetic Background: involves: C57BL/6

Allelic Composition: Leprtm1.1Rll/Lepr+
Genetic Background: 129P3/J-Leprtm1.1Rll

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0005130 decreased follicle stimulating hormone level "less than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb-2J/Leprdb-2J
Genetic Background: involves: C57BL/6J * STOCK Tyrp1b Whrnwi

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

Allelic Composition: Leprdb/Leprdb,Tg(SHBG)4-aGlha/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLt-Leprdb-5J

Allelic Composition: Leprdb/Leprdb,Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BLKS/J * DBA

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Leprdb-rtnd/Leprdb-rtnd
Genetic Background: involves: C57BL/6 * CBA/J

Allelic Composition: Leprdb-rlpy/Leprdb-rlpy
Genetic Background: NU/J

Allelic Composition: Leprdb-dmpg/Leprdb-dmpg
Genetic Background: involves: B10.D2-H8b/Sn * C57BL/6

Allelic Composition: Leprdb-9J/Leprdb-9J
Genetic Background: involves: C57BL/6 * CBA * SWR

 MP:0005220 abnormal exocrine pancreas morphology "malformation of the acinar gland portion of the pancreas that secretes digestive enzymes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

 MP:0005257 abnormal intraocular pressure "anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0005288 abnormal oxygen consumption "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plin1tm1Chan/Plin1tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Leprdb/Leprdb,Tg(Fabp4-Fcor)1Jnak/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * DBA/2

Allelic Composition: Leprtm5Mgmj/Leprtm5Mgmj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb,Tg(Fabp4-Fcor)1Jnak/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * DBA/2

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: FVB.BKS-Leprdb

Allelic Composition: Leprdb/Lepr+
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

Allelic Composition: Foxo1tm2.1Dac/Foxo1tm2.1Dac,Leprdb/Leprdb
Genetic Background: B6.Cg-Foxo1tm2.1Dac Leprdb

Allelic Composition: Leprdb/Lepr+,Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic Background: involves: C3H * C57BL/6 * C57BLKS/J

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: FVB.BKS-Leprdb

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: FVB.BKS-Leprdb

Allelic Composition: Leprdb-NCSU/Leprdb-NCSU
Genetic Background: involves: CD-1

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

Allelic Composition: Leprdb-lb/Leprdb-lb
Genetic Background: C57BL/6NCrl-Leprdb-lb/Crl

Allelic Composition: Leprdb/Leprdb,Ptentm1Hwu/Ptentm1Hwu,Tg(Ins2-cre)25Mgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BLKS/J * DBA

Allelic Composition: Leprtm5Mgmj/Leprtm5Mgmj
Genetic Background: B6.129-Leprtm5Mgmj

Allelic Composition: Leprdb/Lepr+,Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic Background: involves: C3H * C57BL/6 * C57BLKS/J

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Dbsq1C57BLKS/J/Dbsq1C57BLKS/J,Leprdb/Leprdb
Genetic Background: involves: C3H/HeJ * C57BLKS

Allelic Composition: Dbsq1C57BLKS/J/Dbsq1C3H/HeJ,Leprdb/Leprdb
Genetic Background: involves: C3H/HeJ * C57BLKS

Allelic Composition: Leprtm2Mgmj/Leprtm2Mgmj
Genetic Background: B6.Cg-Leprtm2Mgmj

 MP:0005335 abnormal gonadal fat pad "malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0005403 abnormal nerve conduction "anomaly in the act of transmitting electricity along a single nerve" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb-9J/Leprdb-9J
Genetic Background: involves: C57BL/6 * CBA * SWR

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0005451 abnormal body composition "anomalous relative amounts of various components of the body, such as percent body fat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprtm1Rck/Leprtm1.1Rck,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Leprtm1Chua/Leprtm1Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLt-Leprdb-5J

Allelic Composition: Leprdb/Lepr+
Genetic Background: involves: C57BLKS/J

 MP:0005457 abnormal percent body fat "more or less fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLt-Leprdb-5J

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

Allelic Composition: Leprtm3.1Yli/Lepr+
Genetic Background: B6.129-Leprtm3.1Yli

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLtJ

Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: FVB.BKS-Leprdb

Allelic Composition: Leprm1Clo/Leprm1Clo
Genetic Background: STOCK Leprm1Clo/GrsrJ

 MP:0005528 decreased glomerular filtration rate "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1btm1Kin,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Cdkn1btm1Kin/Cdkn1b+,Leprdb/Leprdb
Genetic Background: involves: C57BL/6J * C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

 MP:0005535 abnormal body temperature "deviation in the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

 MP:0005540 decreased albumin excretion "less than the normal amount of this protein voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0005557 increased creatinine clearance "greater than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprtm1Chua/Leprtm1Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Dbsq3C3H/HeJ/Dbsq3C3H/HeJ,Leprdb/Lepr+
Genetic Background: involves: C3H/HeJ * C57BLKS

Allelic Composition: Dbsq3C57BLKS/J/Dbsq3C3H/HeJ,Leprdb/Lepr+
Genetic Background: involves: C3H/HeJ * C57BLKS

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: LeprKK/LeprKK
Genetic Background: involves: C57BL/6J * KK/HlLt

Allelic Composition: Leprdb/Lepr+
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb-ad/Leprdb-ad
Genetic Background: Not Specified

Allelic Composition: Leprdb-NCSU/Leprdb-NCSU
Genetic Background: involves: CD-1

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprdb/Lepr+,Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic Background: involves: C3H * C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

Allelic Composition: Leprm7Btlr/Leprm7Btlr
Genetic Background: C57BL/6J-Leprm7Btlr

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Aqp9tm1Nlsn/Aqp9tm1Nlsn,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Leprdb/Leprdb,Repin1tm1.2Arte/Repin1tm1.2Arte
Genetic Background: involves: BALB/c * C57BL/6 * C57BLKS/J

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0005576 decreased pulmonary ventilation "less than the normal total volume of gas per minute inspired or expired " [RGD:Rat Genome Database submission]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0005580 periinsulitis "early pancreatic infiltration of mononuclear cells around pancreatic Langerhans islets" [J:11442, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLt-Leprdb-5J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BLKS/J

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0005645 abnormal hypothalamus physiology "anomalous function of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

 MP:0005661 decreased circulating adrenaline level "less than the normal concentration in the blood of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adrb2tm1Kry/Adrb2+,Lepob/Lep+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: C57BL/6 * FVB * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0005664 decreased circulating noradrenaline level "less than the normal blood concentration of this precursor of epinephrine that is a widespread central and autonomic neurotransmitter" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adrb2tm1Kry/Adrb2+,Lepob/Lep+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: C57BL/6 * FVB * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0005666 abnormal adipose tissue physiology "functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Leprdb/Leprdb,Repin1tm1.2Arte/Repin1tm1.2Arte
Genetic Background: involves: BALB/c * C57BL/6 * C57BLKS/J

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Leprtm2Mgmj/Leprtm2Mgmj
Genetic Background: B6.Cg-Leprtm2Mgmj

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Leprtm1Rck/Leprtm1.1Rck,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

Allelic Composition: Leprtm1Chua/Leprtm1Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLt-Leprdb-5J

Allelic Composition: LeprKK/LeprKK
Genetic Background: involves: C57BL/6J * KK/HlLt

Allelic Composition: Leprdb/Lepr+
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb-NCSU/Leprdb-NCSU
Genetic Background: involves: CD-1

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

Allelic Composition: Leprtm3.1Yli/Leprtm3.1Yli
Genetic Background: B6.129-Leprtm3.1Yli

Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Leprtm5Mgmj/Leprtm5Mgmj
Genetic Background: B6.129-Leprtm5Mgmj

Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Leprtm5Mgmj/Leprtm5Mgmj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Leprdb/Leprdb,Tg(SHBG)4-aGlha/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

 MP:0006036 abnormal mitochondrial physiology 
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Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0006315 abnormal kidney protein excretion "anomaly in the amount of protein eliminated by the kidneys" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ropn1Gt(OST21705)Lex/Ropn1Gt(OST21705)Lex,Ropn1lGt(OST20298)Lex/Ropn1lGt(OST20298)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/Jcl

 MP:0006353 incleased glycosylated hemoglobin level "greater than normal blood concentration of a modified form of hemoglobin with an attached saccharide molecule " [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator", Riken ENU:Hiroshi Masuya]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0008295 abnormal zona reticularis morphology "any structural anomaly of the inner zone of the adrenal cortex that produces the enzymes that convert pregnenolone, a 21-carbon steroid, to 19-carbon steroids" [MESH:A06.407.071.140.970]
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Allelic Composition: Leprdb-9J/Leprdb-9J
Genetic Background: involves: C57BL/6 * CBA * SWR

 MP:0008329 decreased somatotroph cell number "reduced number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Leprtm1.1Chua/Lepr+,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atxn7tm1Hzo/Atxn7+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008414 abnormal spatial reference memory "anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to naviagate or perform other behavior using such locational cues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0008810 increased circulating iron level "elevation in the concentration of iron in the blood" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0008821 increased blood uric acid level "greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb-lb/Leprdb-lb
Genetic Background: C57BL/6NCrl-Leprdb-lb/Crl

 MP:0008853 decreased abdominal adipose tissue amount "reduction in amount of adipose tissue associated with internal organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb,Tg(Fabp4-Fcor)1Jnak/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * DBA/2

 MP:0008869 anovulation "complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Trp53tm1.2Awbr/Trp53+
Genetic Background: involves: C57BL/6

Allelic Composition: Leprtm1.1Rll/Lepr+
Genetic Background: 129P3/J-Leprtm1.1Rll

 MP:0008902 abnormal renal fat pad morphology "any structural anomaly of the encapsulated adipose tissue associated with the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0008903 abnormal mesenteric fat pad morphology "any structural anomaly of the encapsulated adipose tissue associated with the mesentery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

 MP:0008963 increased carbon dioxide production "increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0008964 decreased carbon dioxide production "reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0009008 delayed estrous cycle "onset of the sexual cycle of females occurring at a later than expected day/age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm5Mgmj/Leprtm5Mgmj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009009 absent estrous cycle "failure of female animals to enter or progress through their sexual cycle" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: involves: 129/Sv

 MP:0009010 abnormal diestrus "any anomaly or aberrant timing of the last phase of the estrous cycle, during which unfertilized eggs are eliminated, the vagina and vulva are at a minimum size, and new follicles begin to undergo a rapid growth for the next ovulation; if pregnancy does not occur, the metestrous phase is ultimately followed by the diestrous phase" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb-2J/Leprdb-2J
Genetic Background: involves: C57BL/6J * STOCK Tyrp1b Whrnwi

 MP:0009019 abnormal metestrus "any anomaly or aberrant timing of the phase of the estrous cycle which follows estrus when mature eggs move through the oviducts and into the uterus; the vulva is no longer bloated, and the vagina is now closed" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb-2J/Leprdb-2J
Genetic Background: involves: C57BL/6J * STOCK Tyrp1b Whrnwi

 MP:0009021 absent estrus "absence or failure of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: involves: 129/Sv

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/Jcl

Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Leprdb/Leprdb,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J

Allelic Composition: Leprdb/Lepr+,Tg(APPswe,PSEN1dE9)85Dbo/0
Genetic Background: involves: C3H * C57BL/6 * C57BLKS/J

 MP:0009133 decreased white fat cell size "reduction in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb,Tg(Fabp4-Fcor)1Jnak/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * DBA/2

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Leprdb-3J/Leprdb-3J
Genetic Background: 129P3/J-Leprdb-3J/J

 MP:0009255 degranulated pancreatic beta cells "insulin-secreting cells of the pancreas do not contain vesicles containing insulin" [MGI:acv "Alicia Valenzuela, Genetic Resources Curator"]
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Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLtJ

Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLt-Leprdb-5J

Allelic Composition: Leprdb-9J/Leprdb-9J
Genetic Background: involves: C57BL/6 * CBA * SWR

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm2Mgmj/Leprtm2Mgmj
Genetic Background: B6.Cg-Leprtm2Mgmj

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0009288 increased epididymal fat pad weight 
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0009298 increased mesenteric fat pad weight 
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Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm4Mgmj/Leprtm4Mgmj
Genetic Background: B6.Cg-Leprtm4Mgmj

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Gcgrtm1Mjch/Gcgrtm1Mjch,Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J * SJL

Allelic Composition: Leprdb/Leprdb,Tg(SHBG)4-aGlha/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Agrp-cre)1Gsb/0
Genetic Background: involves: 129 * FVB/N

 MP:0009488 pancreatic islet cell apoptosis "change in the timing or the number of pancreatic islet cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpbtm1.1Maka/Cebpbtm1.1Maka,Leprdb/Leprdb,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * C57BLKS/J * CBA/J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb,Tg(SHBG)4-aGlha/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

 MP:0009673 increased birth weight "increase in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Leprdb/Lepr+
Genetic Background: involves: C57BLKS/J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0009815 decreased prostaglandin level "reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1Rck/Leprtm1.1Rck,Tg(Syn1-cre)671Jxm/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb-Pas/Leprdb-Pas
Genetic Background: DW/Pas

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprdb/Lepr+
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Slc32a1tm2(cre)Lowl/Slc32a1+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

Allelic Composition: Leprtm5Mgmj/Leprtm5Mgmj
Genetic Background: B6.129-Leprtm5Mgmj

Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Leprtm5Mgmj/Leprtm5Mgmj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0010045 increased omental fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the fold of peritoneal tissue that extends from the stomach to the posterior abdominal wall after associating with the transverse colon" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

 MP:0010087 increased circulating fructosamine level "increase in the concentration in the blood of total non enzymatic glycated proteins in the blood" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1b(EUCOMM)Wtsi/Leprtm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Leprtm1b(EUCOMM)Wtsi/H

 MP:0010149 abnormal synaptic dopamine release "aberrant secretion across synapses of the catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Ntstm1(cre)Mgmj/Nts+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1Jke/Leprtm1Jke,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb-9J/Leprdb-9J
Genetic Background: involves: C57BL/6 * CBA * SWR

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Gh1-cre)bKnmn/0
Genetic Background: involves: 129 * C57BL/6 * FVB

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atxn7tm1Hzo/Atxn7+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010934 increased subcutaneous adipose tissue amount "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0010957 abnormal aerobic respiration "any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor" [GO:0009060]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: C57BLKS/J

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Prlhtm1(cre)Smln/Prlh+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011020 abnormal circadian temperature homeostasis "any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]
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Allelic Composition: Leprm5Btlr/Leprm5Btlr
Genetic Background: C57BL/6-Leprm5Btlr

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprtm1Chua/Leprtm1Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm1Yli/Leprtm1Yli
Genetic Background: B6.129-Leprtm1Yli

Allelic Composition: Leprtm2Yli/Leprtm2Yli
Genetic Background: B6.129-Leprtm2Yli

 MP:0011182 decreased hematopoietic cell number "fewer than expected number of cells of the hematopoietic lineage" [MGI:csmith]
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Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/Ka * SJL

Allelic Composition: Kitltm1.1Sjm/Kitltm2.1Sjm,Leprtm2(cre)Rck/Lepr+,Tg(Tek-cre)12Flv/0
Genetic Background: involves: 129S6/SvEvTac * C3H * C57BL/6 * C57BL/Ka * SJL

 MP:0011312 abnormal kidney afferent arteriole morphology "any structural anomaly of the blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0011369 increased renal glomerulus apoptosis "increase in the number of cells of the kidney glomerulus undergoing programmed cell death" [MGI:anna]
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Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0011377 renal glomerulus fibrosis "formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process" [MGI:anna]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

Allelic Composition: Leprdb/Leprdb,Rock1tm1Leiw/Rock1tm1Leiw
Genetic Background: involves: 129S7/SvEvBrd * C57BLKS/J * FVB/N

 MP:0011430 mesangiolysis "an injurious glomerular process that affects primarily the mesangium, starting with loosening and detachment of its matrix and progressing to dissolution/attenuation with degeneration of mesangial cells; mesangial cells may show only edema and vacuolization, or may undergo severe degeneration and necrosis" [MGI:anna]
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Allelic Composition: Leprdb/Leprdb,Nos3tm1Unc/Nos3tm1Unc
Genetic Background: BKS.Cg-Leprdb Nos3tm1Unc

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Leprtm1.1Chua/Leprtm1.1Chua,Tg(Nr5a1-cre)2Lowl/0
Genetic Background: involves: 129 * C57BL/6J * FVB

Allelic Composition: Leprdb/Lepr+
Genetic Background: involves: C57BLKS/J

Allelic Composition: Leprdb-ad/Leprdb-ad
Genetic Background: Not Specified

Allelic Composition: Leprtm1.1Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Leprtm1.2Chua/Leprtm1.2Chua,Nos1tm1(cre)Mgmj/Nos1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

Allelic Composition: Leprtm5Mgmj/Leprtm5Mgmj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Gdf15tm1Sjl/Gdf15tm1Sjl,Leprdb/Leprdb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BLKS/J

 MP:0012555 decreased cell death "decreased occurrence of the cessation of function at the cellular level" [http://orcid.org/0000-0001-5208-3432]
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Allelic Composition: Leprm7Btlr/Leprm7Btlr
Genetic Background: C57BL/6J-Leprm7Btlr

 MP:0014121 increased pancreatic islet cell apoptosis "increase in the number of pancreatic islet cells undergoing programmed cell death" [MGI:Anna]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/Jcl

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Leprdb/Leprdb,Repin1tm1.2Arte/Repin1tm1.2Arte
Genetic Background: involves: BALB/c * C57BL/6 * C57BLKS/J

 MP:0020001 decreased response to antigen "decreased or weak immune response after exposure to an antigen" [GOC:NV]
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Allelic Composition: Leprm7Btlr/Leprm7Btlr
Genetic Background: C57BL/6J-Leprm7Btlr

 MP:0020087 increased susceptibility to non-insulin-dependent diabetes "increased likelihood to develop non-insulin-dependent diabetes" [GOC:NV]
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Allelic Composition: Leprtm1Jke/Leprtm1Jke
Genetic Background: involves: 129X1/SvJ

 MP:0020386 adipose tissue inflammation "local accumulation of fluid, plasma proteins, and leukocytes in adipose tissue" [MGI:anna, PMID:24662293, PMID:24695736, PMID:26629401]
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Allelic Composition: Leprdb-lb/Leprdb-lb
Genetic Background: C57BL/6NCrl-Leprdb-lb/Crl

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0020411 increased abdominal adipose tissue amount "increase in amount of adipose tissue associated with internal organs" [MGI:anna]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Leprtm1.1Chua/Leprtm1.1Chua,Tg(Pomc1-cre)16Lowl/0
Genetic Background: involves: 129 * 129S4/SvJae * 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0020477 abnormal locomotor circadian rhythm "any anomaly in the rhythm of the locomotor activity of an organism during its 24 hour activity cycle" [GO:0045475]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: BKS.Cg-Dock7m +/+ Leprdb/J

 MP:0020518 renal glomerular protein deposits "any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0020519 renal glomerular immunoglobulin deposits "any anomalous accumulation of immunoglobulins in the renal glomerulus" [PMID:12764198, PMID:17685926]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / reaction / complex
 ENSMUSG00000059201 Lep / P41160 / Leptin / P41159*  / reaction / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / reaction / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / reaction / complex
 ENSMUSG00000030733 Sh2b1 / Q91ZM2 / SH2B adapter protein 1 / Q9NRF2* / SH2B adaptor protein 1*  / reaction / complex
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / reaction / complex
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / complex / reaction
 ENSMUSG00000057722 Lepr / P48356 / Leptin receptor / P48357*  / complex






 

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