ENSMUSG00000030733


Mus musculus

Features
Gene ID: ENSMUSG00000030733
  
Biological name :Sh2b1
  
Synonyms : Q91ZM2 / Sh2b1 / SH2B adapter protein 1
  
Possible biological names infered from orthology : Q9NRF2 / SH2B adaptor protein 1
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 126466994
Gene end: 126475424
  
Corresponding Affymetrix probe sets: 10567903 (MoGene1.0st)   1431438_at (Mouse Genome 430 2.0 Array)   1448874_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000146282
Ensembl peptide - ENSMUSP00000146121
Ensembl peptide - ENSMUSP00000146229
Ensembl peptide - ENSMUSP00000032978
Ensembl peptide - ENSMUSP00000145554
Ensembl peptide - ENSMUSP00000145754
Ensembl peptide - ENSMUSP00000145842
Ensembl peptide - ENSMUSP00000145953
NCBI entrez gene - 20399     See in Manteia.
MGI - MGI:1201407
RefSeq - XM_006507487
RefSeq - NM_001081459
RefSeq - NM_001289538
RefSeq - NM_001289539
RefSeq - NM_001289540
RefSeq - NM_001289541
RefSeq - NM_001289542
RefSeq - NM_011363
RefSeq - XM_006507478
RefSeq - XM_006507480
RefSeq - XM_006507481
RefSeq - XM_006507482
RefSeq - XM_006507485
RefSeq Peptide - NP_001276470
RefSeq Peptide - NP_035493
RefSeq Peptide - NP_001276469
RefSeq Peptide - NP_001276471
RefSeq Peptide - NP_001074928
RefSeq Peptide - NP_001276467
RefSeq Peptide - NP_001276468
swissprot - Q91ZM2
swissprot - A0A0U1RQ35
Ensembl - ENSMUSG00000030733
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sh2b1ENSDARG00000057679Danio rerio
 SH2B1ENSG00000178188Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sh2b2 / Q9JID9 / SH2B adaptor protein 2ENSMUSG0000000505733
Sh2b3 / O09039 / SH2B adapter protein 3 / Q9UQQ2* / SH2B adaptor protein 3*ENSMUSG0000004259425


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015012  Phenylalanine zipper
 IPR030521  SH2B adapter protein 1
 IPR030523  SH2B adapter protein
 IPR035057  SH2B1, SH2 domain
 IPR036290  Phenylalanine zipper superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0030032 lamellipodium assembly IDA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IDA
 biological_processGO:2000278 regulation of DNA biosynthetic process IMP
 cellular_componentGO:0001726 ruffle TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035591 signaling adaptor activity IEA


Pathways (from Reactome)
Pathway description
Prolactin receptor signaling
Growth hormone receptor signaling
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001125 abnormal oocytes "anomalous structure of immature ova" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: KitW-44J/Kit+
Genetic Background: B6.C3-KitW-44J/J

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: KitW-44J/Kit+
Genetic Background: B6.C3-KitW-44J/J

Allelic Composition: Sh2b1tm1Lr/Sh2b1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: KitW-44J/Kit+
Genetic Background: B6.C3-KitW-44J/J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0001940 testicular hypoplasia "decreased cell number in the testicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0002631 abnormal epididymis morphology "malformation of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(rtTA,EGFP)Nagy/Gt(ROSA)26Sor+,Ptf1atm1.1(cre)Cvw/Ptf1a+,Tg(tetO-Kras2)12Hev/0,Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6J * FVB/N

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0003572 abnormal uterus development "abnormal morphogenesis of the female muscular organ of gestation" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0004856 decreased ovary weight "reduction in the average weight of the female reproductive gland containing the germ cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0005158 ovary hypoplasia "underdeveloped ovaries, usually due to reduced cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:78931]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: KitW-44J/Kit+
Genetic Background: B6.C3-KitW-44J/J

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: KitW-44J/Kit+
Genetic Background: B6.C3-KitW-44J/J

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: KitW-44J/Kit+
Genetic Background: B6.C3-KitW-44J/J

 MP:0005536 Leydig cell hypoplasia "reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0008974 proportional dwarf "abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Cyp19a1tm1Esi/Cyp19a1tm1Esi
Genetic Background: involves: 129S6/SvEvTac

 MP:0011819 increased pancreatic beta cell proliferation "increase in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division" [CL:0000169]
Show

Allelic Composition: Sh2b1tm2.1Lr/Sh2b1tm2.1Lr,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / reaction / complex
 ENSMUSG00000057722 Lepr / P48356 / Leptin receptor / P48357*  / complex / reaction
 ENSMUSG00000030733 Sh2b1 / Q91ZM2 / SH2B adapter protein 1 / Q9NRF2* / SH2B adaptor protein 1*  / reaction / complex
 ENSMUSG00000005268 Prlr / Q08501 / prolactin receptor / P16471*  / reaction / complex
 ENSMUSG00000020713 Gh / P06880 / Somatotropin / GH2* / GH1* / CSH2* / CSH1* / CSHL1* / P01241* / Q14406* / P0DML2* / P0DML3* / P01242* / growth hormone 1* / growth hormone 2* / chorionic somatomammotropin ho...  / reaction / complex
 ENSMUSG00000059201 Lep / P41160 / Leptin / P41159*  / complex / reaction






 

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