ENSMUSG00000059201


Mus musculus

Features
Gene ID: ENSMUSG00000059201
  
Biological name :Lep
  
Synonyms : Lep / Leptin / P41160
  
Possible biological names infered from orthology : P41159
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: A3.3
Gene start: 29060220
Gene end: 29073877
  
Corresponding Affymetrix probe sets: 10536789 (MoGene1.0st)   1422582_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000067046
Ensembl peptide - ENSMUSP00000130087
NCBI entrez gene - 16846     See in Manteia.
MGI - MGI:104663
RefSeq - XM_006504999
RefSeq - NM_008493
RefSeq Peptide - NP_032519
swissprot - P41160
swissprot - Q544U0
swissprot - E9Q7Z0
Ensembl - ENSMUSG00000059201
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LEPENSG00000174697Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000065  Leptin
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001542 ovulation from ovarian follicle IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0001932 regulation of protein phosphorylation IDA
 biological_processGO:0001936 regulation of endothelial cell proliferation IEA
 biological_processGO:0002021 response to dietary excess IEA
 biological_processGO:0003300 cardiac muscle hypertrophy IEA
 biological_processGO:0006006 glucose metabolic process IMP
 biological_processGO:0006111 regulation of gluconeogenesis IMP
 biological_processGO:0006112 energy reserve metabolic process IEA
 biological_processGO:0006114 glycerol biosynthetic process IEA
 biological_processGO:0006629 lipid metabolic process IMP
 biological_processGO:0006635 fatty acid beta-oxidation IGI
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0008203 cholesterol metabolic process IGI
 biological_processGO:0008206 bile acid metabolic process IDA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008343 adult feeding behavior IDA
 biological_processGO:0009062 fatty acid catabolic process IEA
 biological_processGO:0009892 negative regulation of metabolic process IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010507 negative regulation of autophagy IEA
 biological_processGO:0010888 negative regulation of lipid storage IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0019222 regulation of metabolic process IMP
 biological_processGO:0019953 sexual reproduction IEA
 biological_processGO:0021954 central nervous system neuron development IMP
 biological_processGO:0030073 insulin secretion IGI
 biological_processGO:0030217 T cell differentiation IMP
 biological_processGO:0030300 regulation of intestinal cholesterol absorption IDA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0032008 positive regulation of TOR signaling IEA
 biological_processGO:0032099 negative regulation of appetite IDA
 biological_processGO:0032310 prostaglandin secretion IEA
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032615 interleukin-12 production IDA
 biological_processGO:0032635 interleukin-6 production IDA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IDA
 biological_processGO:0032814 regulation of natural killer cell activation IEA
 biological_processGO:0032817 regulation of natural killer cell proliferation IEA
 biological_processGO:0032868 response to insulin IMP
 biological_processGO:0033197 response to vitamin E IEA
 biological_processGO:0033210 leptin-mediated signaling pathway IEA
 biological_processGO:0033686 positive regulation of luteinizing hormone secretion IEA
 biological_processGO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035630 bone mineralization involved in bone maturation IEA
 biological_processGO:0038108 negative regulation of appetite by leptin-mediated signaling pathway IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042269 regulation of natural killer cell mediated cytotoxicity IEA
 biological_processGO:0042307 positive regulation of protein import into nucleus IDA
 biological_processGO:0042445 hormone metabolic process IMP
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0042593 glucose homeostasis IGI
 biological_processGO:0042755 eating behavior IGI
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043270 positive regulation of ion transport IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0044320 cellular response to leptin stimulus IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045598 regulation of fat cell differentiation IGI
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0045906 negative regulation of vasoconstriction IEA
 biological_processGO:0046325 negative regulation of glucose import IEA
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IEA
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway IEA
 biological_processGO:0046850 regulation of bone remodeling IMP
 biological_processGO:0046881 positive regulation of follicle-stimulating hormone secretion IEA
 biological_processGO:0048639 positive regulation of developmental growth IEA
 biological_processGO:0050796 regulation of insulin secretion IMP
 biological_processGO:0050810 regulation of steroid biosynthetic process IMP
 biological_processGO:0050892 intestinal absorption IEA
 biological_processGO:0050901 leukocyte tethering or rolling IEA
 biological_processGO:0050999 regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IDA
 biological_processGO:0060587 regulation of lipoprotein lipid oxidation IEA
 biological_processGO:0060612 adipose tissue development IGI
 biological_processGO:0061037 negative regulation of cartilage development IEA
 biological_processGO:0070093 negative regulation of glucagon secretion IDA
 biological_processGO:0071298 cellular response to L-ascorbic acid IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0072604 interleukin-6 secretion IEA
 biological_processGO:0072606 interleukin-8 secretion IEA
 biological_processGO:0090335 regulation of brown fat cell differentiation IDA
 biological_processGO:0098868 bone growth IMP
 biological_processGO:1900015 regulation of cytokine production involved in inflammatory response IEA
 biological_processGO:1900180 regulation of protein localization to nucleus IMP
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:1904651 positive regulation of fat cell apoptotic process IEA
 biological_processGO:1990051 activation of protein kinase C activity IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 biological_processGO:2000486 negative regulation of glutamine transport IEA
 biological_processGO:2000491 positive regulation of hepatic stellate cell activation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051428 peptide hormone receptor binding IEA


Pathways (from Reactome)
Pathway description
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and deacylation of Ghrelin


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000003 abnormal adipose tissue morphology "structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Zfp423tm1Reed/Zfp423tm1Reed
Genetic Background: involves: 129 * C57BL/6

 MP:0000008 increased white fat amount "increased quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0000180 abnormal circulating cholesterol level "anomalous concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Scn5atm1Pec/Scn5a+
Genetic Background: involves: Swiss

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: BKS.Cg-Lepob/J

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Ldlrtm1Her/Ldlrtm1Her,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: BKS.Cg-Lepob/J

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Ldlrtm1Her/Ldlrtm1Her,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv * BALB/c * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Ldlrtm1Her/Ldlrtm1Her,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: BKS.Cg-Lepob/J

Allelic Composition: Dmbx1tm1Sse/Dmbx1tm1Sse,Lepob/Lepob
Genetic Background: involves: ICR

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Ldlrtm1Her/Ldlrtm1Her,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Dmrtc2tm1.1Zark/Dmrtc2tm1.1Zark,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001130 abnormal ovarian folliculogenesis "atypical formation or failure to form the spherical ovum in the ovary" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:35782]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
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Allelic Composition: Pax8tm1Pgr/Pax8tm1Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001142 abnormal vaginal opening "a malformed or absent opening to the genital canal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax8tm1Pgr/Pax8tm1Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001259 abnormal body weight "anomaly in average weight compared to the norm" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Gnai1tm1Drs/Gnai1+
Genetic Background: Not Specified

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Dmbx1tm1Sse/Dmbx1tm1Sse,Lepob/Lepob
Genetic Background: involves: ICR

Allelic Composition: Cidectm1Pli/Cidectm1Pli,Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Lepob/Lepob,Tg(Eno2-Pomc)1Mobb/?
Genetic Background: involves: C3H * C57BL/6

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lep+,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Acacbtm1.2Lowl/Acacbtm1.2Lowl,Lepob/Lepob
Genetic Background: involves: 129S6/SvEvTac * FVB/N

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Ccar2tm1Dac/Ccar2tm1Dac,Lepob/Lepob
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Leptm1.2Gvcao/Leptm1.2Gvcao
Genetic Background: involves: 129S4/SvJaeSor * FVB/NJ * FVB/NTac

 MP:0001261 obese "excessively fat; an increase in fat in the subcutaneous connective tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob,Npy5rtm1Rpa/Npy5rtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Npbwr1tm1Rck/Npbwr1tm1Rck,Lepob/Lepob
Genetic Background: involves: 129P/Ola * C57BL/6J

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: D2.Cg-Lepob/Chua

Allelic Composition: Leptm1Kry/Leptm1Kry
Genetic Background: Not Specified

Allelic Composition: Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6J * SJL * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepob/Lepob-2J
Genetic Background: involves: C57BL/6J * SM/Ckc

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

Allelic Composition: Kittm1Rosay/Kit+,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Lepm1Btlr/Lepm1Btlr
Genetic Background: C57BL/6J-Lepm1Btlr

Allelic Composition: Lepm2Btlr/Lepm2Btlr
Genetic Background: C57BL/6J-Lepm2Btlr

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Ldlrtm1Her/Ldlrtm1Her,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Leptm1.1Gvcao/Leptm1.1Gvcao,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NTac

Allelic Composition: Leptm1.2Gvcao/Leptm1.2Gvcao
Genetic Background: involves: 129S4/SvJaeSor * FVB/NJ * FVB/NTac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob,Mapk8tm1Wag/Mapk8tm1Wag
Genetic Background: B6.Cg-Lepob Mapk8tm1Wag

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv * BALB/c * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepob/Lepob,Tg(Npy-MAPT/Sapphire)1Rck/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lepob/Lepob,Tg(Pomc-MAPT/Topaz)1Rck/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lepob/Lepob,Tg(Pmch-ATXN3*)3Rck/0
Genetic Background: involves: C57BL/6J * FVB/NJ

Allelic Composition: Hmga2tm1Cha/Hmga2+,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Akt2tm1.2Mbb/Akt2tm1.2Mbb,Lepob/Lepob,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

Allelic Composition: Akt2tm1.1Mbb/Akt2+,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

Allelic Composition: Lepob/Lepob,Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Pmchtm1.1(DTR)Rpa/Pmch+
Genetic Background: B6.Cg-Lepob Pmchtm1.1(DTR)Rpa

Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

Allelic Composition: Lepob/Lepob,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: B6.Cg-Nfe2l2tm1Mym Lepob

Allelic Composition: Lepob/Lepob,Tg(Ins2-Mir184)4Mnpy/0
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Cnot3tm1.1Tya/Cnot3+,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fitm2tm1.1Dls/Fitm2tm1.1Dls,Lepob/Lepob,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: B6.BKS(D)-Leprdb/J

Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Lepob/Lepob,Tg(Ins2-Mir184)4Mnpy/0
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Hmga2pg-Tg40BCha/Hmga2+
Genetic Background: involves: C57BL/6J * CBA/J

Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Lepob/Lepob,Mir375tm1Stf/Mir375tm1Stf
Genetic Background: B6.Cg-Mir375tm1Stf Lepob

 MP:0001272 increased metastatic potential 
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
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Allelic Composition: Lepob/Lepob,Tg(Pmch-ATXN3*)3Rck/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Mir375tm1Stf/Mir375tm1Stf
Genetic Background: B6.Cg-Mir375tm1Stf Lepob

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
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Allelic Composition: Zfp423tm1Reed/Zfp423tm1Reed
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob,Npy5rtm1Rpa/Npy5rtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0001501 abnormal sleep pattern "deviation from the normal wake/sleep cycle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Scn5atm1Pec/Scn5a+
Genetic Background: involves: Swiss

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Ldlrtm1Her

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: BKS.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/JBomTac

Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

Allelic Composition: Lepob/Lepob
Genetic Background: involves: C57BL/6

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

Allelic Composition: Lepob/Lepob,Nfe2l2tm1.1Jgpi/Nfe2l2tm1.1Jgpi,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: C57BL/6

Allelic Composition: Lepob/Lepob,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: B6.Cg-Nfe2l2tm1Mym Lepob

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Ldlrtm1Her/Ldlrtm1Her,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Lepob/Lepob,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Ldlrtm1Her/Ldlrtm1Her,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Scn5atm1Pec/Scn5a+
Genetic Background: involves: Swiss

Allelic Composition: Ldlrtm1Her/Ldlr+,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Ldlrtm1Her

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: BKS.Cg-Lepob/J

Allelic Composition: Lepob/Lepob,Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv * BALB/c * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepob/Lepob
Genetic Background: involves: C57BL/6

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1,T2dm2C57BL/6J/T2dm2C57BL/6J
Genetic Background: involves: BTBR * C57BL/6J

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: D2.Cg-Lepob/Chua

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: BKS.Cg-Lepob/J

Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

Allelic Composition: Ildr2Dbsm1-DBA/2J/Ildr2Dbsm1-DBA/2J,Lepob/Lepob
Genetic Background: B6.Cg-Ildr2Dbsm1-DBA/2J Lepob

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Kittm1Rosay/Kit+,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob

Allelic Composition: Lepob/Lepob
Genetic Background: involves: BTBR * C57BL/6 * V stock

Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

Allelic Composition: Lepob/Lepob,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: B6.Cg-Nfe2l2tm1Mym Lepob

Allelic Composition: Lepob/Lepob,Tg(Ins2-Mir184)4Mnpy/0
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Gt(ROSA)26Sortm1(Notch1)Dam/Gt(ROSA)26Sor+,Lepob/Lepob,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NJ

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0001560 abnormal circulating insulin level "anomalous blood concentration of this polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001596 hypotension "sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001731 abnormal postnatal growth "anomaly in reaching a developmental stage or stages after birth" [il:Ira Lu, Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob,Pmchtm1.1(DTR)Rpa/Pmch+
Genetic Background: B6.Cg-Lepob Pmchtm1.1(DTR)Rpa

 MP:0001744 hypersecretion of cortisol 
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0001745 increased circulating corticosterone level "greater than the normal concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:54931]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: BKS.Cg-Lepob/J

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob
Genetic Background: BKS.Cg-Lepob/J

Allelic Composition: Lepob/Lepob,Mir375tm1Stf/Mir375tm1Stf
Genetic Background: B6.Cg-Mir375tm1Stf Lepob

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

 MP:0001781 abnormal white fat amount "anomaly in the quantity of the fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Glatm1Kul/Y,Tg(A4GALT)#Sais/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6JJms

Allelic Composition: Lepob/Lepob,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: B6.Cg-Nfe2l2tm1Mym Lepob

Allelic Composition: Fitm2tm1.1Dls/Fitm2tm1.1Dls,Lepob/Lepob,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepob/Lepob,Pmchtm1.1(DTR)Rpa/Pmch+
Genetic Background: B6.Cg-Lepob Pmchtm1.1(DTR)Rpa

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

Allelic Composition: Leptm1.1Gvcao/Leptm1.1Gvcao,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NTac

Allelic Composition: Leptm1.2Gvcao/Leptm1.2Gvcao
Genetic Background: involves: 129S4/SvJaeSor * FVB/NJ * FVB/NTac

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Leptm1.1Gvcao/Leptm1.1Gvcao,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NTac

Allelic Composition: Leptm1.2Gvcao/Leptm1.2Gvcao
Genetic Background: involves: 129S4/SvJaeSor * FVB/NJ * FVB/NTac

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepob/Lepob,Pmchtm1.1(DTR)Rpa/Pmch+
Genetic Background: B6.Cg-Lepob Pmchtm1.1(DTR)Rpa

Allelic Composition: Leptm1.1Gvcao/Leptm1.1Gvcao,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NTac

Allelic Composition: Leptm1.2Gvcao/Leptm1.2Gvcao
Genetic Background: involves: 129S4/SvJaeSor * FVB/NJ * FVB/NTac

 MP:0001927 abnormal oestrous cycle (sensu Rodentia) "failure of or aberrant timing of the sexual cycle of female animals" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Pax8tm1Pgr/Pax8tm1Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob,T2dm2BTBR/T2dm2BTBR
Genetic Background: involves: BTBR * C57BL/6J

Allelic Composition: Lepob/Lepob,T2dm2BTBR/T2dm2C57BL/6J
Genetic Background: involves: BTBR * C57BL/6J

Allelic Composition: Lepob/Lepob,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: D2.Cg-Lepob/Chua

Allelic Composition: Lepob/Lepob
Genetic Background: FVB.Cg-Lepob/Chua

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: BKS.Cg-Lepob/J

Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

Allelic Composition: Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6J * SJL * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Adrb2tm1Kry/Adrb2+,Lepob/Lep+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: C57BL/6 * FVB * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepob/Lepob,Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepob/Lepob,Ptprvtm1Asmi/Ptprv+
Genetic Background: involves: 129P2/OlaHsd * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

Allelic Composition: Lepob/Lepob
Genetic Background: involves: BTBR * C57BL/6 * V stock

Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Lepob/Lepob,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Ldlrtm1Her/Ldlrtm1Her,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Lepob/Lepob,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hrtm1Cct/Hrtm1Cct,Tg(KRT14-Hr)551Cct/0
Genetic Background: involves: 129/Sv * C57BL/6 * SJL

Allelic Composition: Lepob/Lepob,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: B6.Cg-Nfe2l2tm1Mym Lepob

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Akt2tm1.2Mbb/Akt2tm1.2Mbb,Lepob/Lepob,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pax8tm1Pgr/Pax8tm1Pgr
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

Allelic Composition: Lepob/Lepob,Tg(Pmch-ATXN3*)3Rck/0
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0002164 abnormal gland physiology "altered glandular secretion not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Klc1tm1Gsn/Klc1tm1Gsn
Genetic Background: B6.129-Klc1tm1Gsn

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0002397 abnormal bone marrow morphology "structural anomalies in the soft tissue that fills the cavities of bones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0002498 abnormal acute inflammation "aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lepob/Lepob,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: B6.Cg-Nfe2l2tm1Mym Lepob

Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cidectm1Pli/Cidectm1Pli,Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Lepob/Lepob,Nr1i3tm1Dgen/Nr1i3tm1Dgen
Genetic Background: B6.Cg-Nr1i3tm1Dgen Lepob

 MP:0002665 decreased circulating corticosterone level "less than the normal blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002673 abnormal sperm count "increased or decreased numbers of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv * BALB/c * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Cidectm1Pli/Cidectm1Pli,Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob,Mapk8tm1Wag/Mapk8tm1Wag
Genetic Background: B6.Cg-Lepob Mapk8tm1Wag

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Ildr2Dbsm1-DBA/2J/Ildr2Dbsm1-DBA/2J,Lepob/Lepob
Genetic Background: B6.Cg-Ildr2Dbsm1-DBA/2J Lepob

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Lepob/Lepob,Mir375tm1Stf/Mir375tm1Stf
Genetic Background: B6.Cg-Mir375tm1Stf Lepob

Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1
Genetic Background: B6.Cg-Lepob Chr 16BTNTTF

Allelic Composition: Lepob/Lepob,Tg(Ins2-rtTA)2Efr/0,Tg(tetO-Mir184)#Mnpy/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lepob/Lepob,Tg(Ins2-Mir184)4Mnpy/0
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Lepob/Lepob,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0002773 decreased circulating luteinizing hormone level "lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary" [J:35132, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leptm1.1Gvcao/Leptm1.1Gvcao,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NTac

 MP:0002780 decreased circulating testosterone level "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002786 abnormal Leydig cell morphology "malformation or absence of the interstitial cells of the seminiferous tubules that secrete testosterone" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002790 decreased circulating follicle stimulating hormone level "less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leptm1.1Gvcao/Leptm1.1Gvcao,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NTac

Allelic Composition: Leptm1.2Gvcao/Leptm1.2Gvcao
Genetic Background: involves: 129S4/SvJaeSor * FVB/NJ * FVB/NTac

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

 MP:0002865 increased growth rate "accelerated time to reach a developmental stage or stages" [J:32208, il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: BKS.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Lepob/Lepob,Tg(Npy-MAPT/Sapphire)1Rck/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lepob/Lepob,Tg(Pomc-MAPT/Topaz)1Rck/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
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Allelic Composition: Cidectm1Pli/Cidectm1Pli,Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6J * SJL * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp5tm1Hota Lepob

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Lepob

Allelic Composition: Cnot3tm1.1Tya/Cnot3+,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Lepob/Lepob,Tg(Npy-MAPT/Sapphire)1Rck/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002938 white spotting "the appearance of patches of white fur" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Kittm1Rosay/Kit+,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Lepob/Lepob,Tg(Pomc-MAPT/Topaz)1Rck/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lep+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob,Tg(Ins2-Mir184)4Mnpy/0
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: Rac2m3Btlr/Rac2+
Genetic Background: C57BL/6J-Rac2m3Btlr

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0003177 decreased pain threshold "ordinarily painless stimuli, once perceived, are experienced as being painful" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:81734]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0003194 abnormal frequency of paradoxical sleep "abnormal incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0003215 renal interstitial fibrosis "formation of fibrous tissue within the interstices of the kidney as a result of repair or a reactive process" [RGD:Rat Genome Database submission]
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Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob
Genetic Background: D2.Cg-Lepob/Chua

Allelic Composition: Lepob/Lepob,Mir375tm1Stf/Mir375tm1Stf
Genetic Background: B6.Cg-Mir375tm1Stf Lepob

Allelic Composition: Lepob/Lepob
Genetic Background: involves: BTBR * C57BL/6 * V stock

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Lepob/Lepob,Mir375tm1Stf/Mir375tm1Stf
Genetic Background: B6.Cg-Mir375tm1Stf Lepob

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Akt2tm1.2Mbb/Akt2tm1.2Mbb,Lepob/Lepob,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

Allelic Composition: Akt2tm1.1Mbb/Akt2+,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

Allelic Composition: Lepob/Lepob,Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003503 decreased activity of thyroid 
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0003562 abnormal beta cell physiology "anomaly in the function of the insulin-producing cells of the islets of Langerhans in the pancreas" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: BKS.Cg-Lepob/J

 MP:0003564 abnormal insulin secretion "aberrant release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0003619 abnormal urine color "any alteration from the usual straw-coloration of the urine" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Lepob/Lepob,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: B6.Cg-Nfe2l2tm1Mym Lepob

 MP:0003645 increased number of pancreatic beta cells "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob
Genetic Background: D2.Cg-Lepob/Chua

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Lepob/Lepob,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/JRj

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0003867 increased defecation "increase in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

 MP:0003953 abnormal hormone level "aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0003956 abnormal body size "anomaly in the average body weight, height and/or length of an organism compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob,Tg(Eno2-Pomc)1Mobb/?
Genetic Background: involves: C3H * C57BL/6

 MP:0003960 increased lean body mass "more than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Ccar2tm1Dac/Ccar2tm1Dac,Lepob/Lepob
Genetic Background: involves: 129 * C57BL/6J

 MP:0003962 abnormal adrenaline level "aberrant concentration in the blood or tissues of this catacholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003963 abnormal corticosterone level "anomalous blood or tissue concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0003972 decreased pituitary hormone level "less than the expected amount of any of the pituitary hormones in the blood or tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leptm1.2Gvcao/Leptm1.2Gvcao
Genetic Background: involves: 129S4/SvJaeSor * FVB/NJ * FVB/NTac

 MP:0003973 increased pituitary hormone level "greater than the expected amount of any of the pituitary hormones in the blood or tissues" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leptm1.1Gvcao/Leptm1.1Gvcao,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NTac

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

 MP:0004016 decreased bone mass "a reduction in the total amount of bone tissue contained in the skeleton" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0004112 abnormal arteriole morphology "structural anomaly in the small diameter vessels that branch from the arteries and lead to the capillaries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0004183 abnormal sympathetic nervous system physiology "anomaly in the function of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0004847 abnormal liver weight "anomaly in the average weight of the bile-secreting exocrine gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0004848 abnormal liver size "anomaly in the average size of the liver " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Tg(Eno2-Pomc)1Mobb/?
Genetic Background: involves: C3H * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0004890 decreased energy expenditure "decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0004909 increased seminal gland weight "increase in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004910 decreased seminal gland weight "reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: C57BL/6

 MP:0005120 decreased circulating growth hormone level "less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leptm1.1Gvcao/Leptm1.1Gvcao,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NTac

 MP:0005121 decreased circulating prolactin level "less than expected blood concentration of the hormone that stimulates milk secretion " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leptm1.1Gvcao/Leptm1.1Gvcao,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NTac

Allelic Composition: Leptm1.2Gvcao/Leptm1.2Gvcao
Genetic Background: involves: 129S4/SvJaeSor * FVB/NJ * FVB/NTac

 MP:0005129 increased adrenocorticotropin level "increased concentration of adrenocorticotropic hormone " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: BKS.Cg-Lepob/J

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Ldlrtm1Her

Allelic Composition: Ldlrtm1Her/Ldlr+,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Ldlrtm1Her

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: BKS.Cg-Lepob/J

Allelic Composition: Lepob/Lepob,Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv * BALB/c * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

Allelic Composition: Lepob/Lepob
Genetic Background: involves: C57BL/6

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Ldlrtm1Her/Ldlrtm1Her,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Lepob/Lepob,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

 MP:0005180 abnormal circulating testosterone level "aberration in the blood concentration of this most potent androgen" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob
Genetic Background: D2.Cg-Lepob/Chua

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

 MP:0005217 abnormal pancreatic beta cell morphology "malformation of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: KitW-82J/Kit+
Genetic Background: involves: C3HeB/FeLe

 MP:0005280 abnormal fatty acid level "anomalous concentration of organic, monobasic acids derived from hydrocarbons and which are complexed with serum albumin for transport; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob,Tg(Eno2-Pomc)1Mobb/?
Genetic Background: involves: C3H * C57BL/6

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0005288 abnormal oxygen consumption "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob,Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cnot3tm1.1Tya/Cnot3+,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005290 decreased oxygen consumption "less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005291 abnormal glucose tolerance "deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cidectm1Pli/Cidectm1Pli,Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6J * SJL * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp5tm1Hota Lepob

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Lepob

Allelic Composition: Lepob/Lepob,Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepob/Lepob,Pmchtm1.1(DTR)Rpa/Pmch+
Genetic Background: B6.Cg-Lepob Pmchtm1.1(DTR)Rpa

Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Lepob/Lepob,Tg(Myh6-Med13)1Eno/0
Genetic Background: involves: C57BL/6

Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Lepob/Lepob,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

Allelic Composition: Cnot3tm1.1Tya/Cnot3+,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Adipoqtm1Pesch/Adipoqtm1Pesch,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Ildr2Dbsm1-DBA/2J/Ildr2Dbsm1-DBA/2J,Lepob/Lepob
Genetic Background: B6.Cg-Ildr2Dbsm1-DBA/2J Lepob

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Ccar2tm1Dac/Ccar2tm1Dac,Lepob/Lepob
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv * BALB/c * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0005318 decreased triglyceride level "lower than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob,Plin4tm1Vlcg/Plin4tm1Vlcg
Genetic Background: involves: C57BL/6J

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bmpr1bTg(ACTB-FLP)4917Dym/Bmpr1bTg(ACTB-FLP)4917Dym,Gdf5bp-J/Gdf5bp-J
Genetic Background: involves: A/J * C57BL/6 * SJL

Allelic Composition: Dbmc1BTBR/Dbmc1C57BL/6J,Lepob/Lepob
Genetic Background: involves: BTBR * C57BL/6J

Allelic Composition: Dbmc2BTBR/Dbmc2BTBR,Lepob/Lepob
Genetic Background: involves: BTBR * C57BL/6J

Allelic Composition: Dbmc2BTBR/Dbmc2C57BL/6J,Lepob/Lepob
Genetic Background: involves: BTBR * C57BL/6J

Allelic Composition: Dbmc3C57BL/6J/Dbmc3C57BL/6J,Lepob/Lepob
Genetic Background: involves: BTBR * C57BL/6J

Allelic Composition: Dbmc3BTBR/Dbmc3C57BL/6J,Lepob/Lepob
Genetic Background: involves: BTBR * C57BL/6J

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lepob/Lepob,Nfe2l2tm1.1Jgpi/Nfe2l2tm1.1Jgpi,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: C57BL/6

Allelic Composition: Lepob/Lepob,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: B6.Cg-Nfe2l2tm1Mym Lepob

Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Lepob/Lepob,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005335 abnormal gonadal fat pad "malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
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Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cidectm1Pli/Cidectm1Pli,Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Ldlrtm1Her

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Ldlrtm1Her/Ldlrtm1Her,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Apobtm2Sgy/Apobtm2Sgy,Apoetm1Unc/Apoetm1Unc,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6

 MP:0005345 abnormal circulating corticosterone level "anomalous blood concentration of this adrenocortical steroid; induces glycogen deposition and regulates sodium conservation and potassium secretion" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005407 hyperalgesia "increased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0005418 abnormal circulating hormone level "anomalous blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

 MP:0005438 abnormal glycogen homeostasis "abnormal processing and or utilization of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

Allelic Composition: Lepob/Lepob,Tg(Eno2-Pomc)1Mobb/?
Genetic Background: involves: C3H * C57BL/6

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005452 abnormal body fat amount "more or less than the normal total amount of connective tissue composed of fat cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Cidectm1Pli/Cidectm1Pli,Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0005455 increased weight gain "greater increase in body weight over existing weight when compared to the average increase in weight on the same diet, with equal energy (calorie) intake " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:42702]
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Allelic Composition: Lepob/Lepob,Npy4rtm1.1Hhz/Npy4rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0005491 islet cell hyperplasia "increased numbers cells within the structures that are scattered throughout the pancreas and comprise its endocrine portion" [J:48446, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: BTBR * C57BL/6 * V stock

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0005535 abnormal body temperature "deviation in the level of heat natural to a living being" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob,Tg(Eno2-Pomc)1Mobb/?
Genetic Background: involves: C3H * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Lepob/Lepob,Mir375tm1Stf/Mir375tm1Stf
Genetic Background: B6.Cg-Mir375tm1Stf Lepob

Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

Allelic Composition: Akt2tm1.2Mbb/Akt2tm1.2Mbb,Lepob/Lepob,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

Allelic Composition: Lepob/Lepob,Stxbp5lT2dm1/Stxbp5lT2dm1
Genetic Background: B6.Cg-Lepob Chr 16BTNTTF

Allelic Composition: Lepob/Lepob,Steap4tm1Dgen/Steap4tm1Dgen
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Lepob/Lepob,Nfe2l2tm1.1Jgpi/Nfe2l2tm1.1Jgpi,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: C57BL/6

Allelic Composition: Lepob/Lepob,Tg(Ins2-rtTA)2Efr/0,Tg(tetO-Mir184)#Mnpy/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lepob/Lepob,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Lepob/Lepob,Mapk8tm1Wag/Mapk8tm1Wag
Genetic Background: B6.Cg-Lepob Mapk8tm1Wag

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob,Npy2rtm1Pern/Npy2rtm1Pern
Genetic Background: involves: 129/Sv * BALB/c * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepob/Lepob,Tg(Pmch-ATXN3*)3Rck/0
Genetic Background: involves: C57BL/6J * FVB/NJ

Allelic Composition: Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6J * SJL * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Adrb2tm1Kry/Adrb2+,Lepob/Lep+,Tg(Col1a1-cre)1Kry/0
Genetic Background: involves: C57BL/6 * FVB * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepob/Lepob,Ptprvtm1Asmi/Ptprvtm1Asmi
Genetic Background: involves: 129P2/OlaHsd * STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Lepob/Lepob,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

 MP:0005605 increased bone mass "an increase in the total amount of bone tissue contained in the skeleton" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lep+,Tg(Apoe-Lepr)1Kry/0
Genetic Background: involves: C57BL/6J

Allelic Composition: Leptm1Kry/Leptm1Kry
Genetic Background: Not Specified

Allelic Composition: Lepob/Lep+
Genetic Background: involves: C57BL/6J

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Leptm1.1Gvcao/Leptm1.1Gvcao,Tg(Adipoq-cre)1Evdr/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J * FVB/NTac

Allelic Composition: Leptm1.2Gvcao/Leptm1.2Gvcao
Genetic Background: involves: 129S4/SvJaeSor * FVB/NJ * FVB/NTac

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Clockm1Jt/Clockm1Jt,Lepob/Lepob
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: C57BL/6

 MP:0008329 decreased somatotroph cell number "reduced number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin" [CL:0000295, MESH:A06.407.747.608.937]
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Allelic Composition: Leptm1.2Gvcao/Leptm1.2Gvcao
Genetic Background: involves: 129S4/SvJaeSor * FVB/NJ * FVB/NTac

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0008459 abnormal circulating pancreatic peptide level "anomaly in the amount of the 36-amino acid pancreatic hormone in the blood that is secreted mainly by endocrine cells found at the periphery of the islets of Langerhans in response to ingestions, and regulates gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D06.472.699.587.700]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008469 abnormal protein level "anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: MitfMi/Mitftm1Arnh
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Lepob/Lepob,Serpine1tm1Mlg/Serpine1tm1Mlg
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0008844 decreased subcutaneous adipose tissue amount "reduction in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fitm2tm1.1Dls/Fitm2tm1.1Dls,Lepob/Lepob,Tg(Fabp4-cre)1Rev/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0008908 increased total fat pad weight "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Npy5rtm1Rpa/Npy5rtm1Rpa
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Lepob/Lepob,Pmchtm1.1(DTR)Rpa/Pmch+
Genetic Background: B6.Cg-Lepob Pmchtm1.1(DTR)Rpa

Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008964 decreased carbon dioxide production "reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009011 prolonged diestrus "increase in the length of the diestrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009017 prolonged estrus "increase in the length of the estrous phase of the estrous cycle in female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009108 increased pancreas weight "increase in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [MESH:A03.734, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009113 increased pancreatic beta cell mass "greater total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Ago2tm1.1Tara/Ago2tm1.1Tara,Lepob/Lepob,Tg(Ins2-cre)23Herr/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J

 MP:0009114 decreased pancreatic beta cell mass "reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ildr2Dbsm1-DBA/2J/Ildr2Dbsm1-DBA/2J,Lepob/Lepob
Genetic Background: B6.Cg-Ildr2Dbsm1-DBA/2J Lepob

Allelic Composition: Lepob/Lepob,Mir375tm1Stf/Mir375tm1Stf
Genetic Background: B6.Cg-Mir375tm1Stf Lepob

Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

Allelic Composition: Lepob/Lepob,Tg(Ins2-Mir184)4Mnpy/0
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0009117 abnormal white fat cell morphology "any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole" [MESH:A11.329.114.500]
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Allelic Composition: Lepob/Lepob,Nfe2l2tm1.1Jgpi/Nfe2l2tm1.1Jgpi,Tg(Fabp4-cre)1Rev/0
Genetic Background: involves: C57BL/6

Allelic Composition: Lepob/Lepob,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: B6.Cg-Nfe2l2tm1Mym Lepob

 MP:0009118 increased white fat cell size "increase in the size of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

 MP:0009124 increased brown fat cell lipid droplet size "increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

 MP:0009130 increased white fat cell number "increase in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

 MP:0009131 decreased white fat cell number "reduction in the number of fat cells with light coloration and few mitochondria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0009167 increased pancreatic islet number "increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009171 enlarged pancreatic islets "increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Lepob/Lepob
Genetic Background: BKS.Cg-Lepob/J

Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

 MP:0009176 increased pancreatic alpha cell number "increase in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Lepob/Lepob,Mir375tm1Stf/Mir375tm1Stf
Genetic Background: B6.Cg-Mir375tm1Stf Lepob

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: BTBR * C57BL/6 * V stock

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
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Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009283 decreased gonadal fat pad weight "less than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009289 decreased epididymal fat pad weight 
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009292 increased inguinal fat pad weight 
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009293 decreased inguinal fat pad weight 
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Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lepob/Lepob,Lgals12tm1Ftl/Lgals12tm1Ftl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009294 increased interscapular fat pad weight 
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Ftotm1Urt/Ftotm1Urt,Lepob/Lepob
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009299 decreased mesenteric fat pad weight 
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Allelic Composition: Lepob/Lepob,Npy2rtm1.1Hhz/Npy2rtm1.1Hhz
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Hmga2tm1Cha/Hmga2tm1Cha,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009305 decreased retroperitoneal fat pad weight 
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Allelic Composition: Lepob/Lepob,Rcan2tm1Ypt/Rcan2tm1Ypt
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: C57BL/6

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Ldlrtm1Her

Allelic Composition: Ldlrtm1Her/Ldlr+,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Ldlrtm1Her

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepob/Lepob
Genetic Background: involves: C57BL/6

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Lepob/Lepob,Mogat1tm1Far/Mogat1tm1Far
Genetic Background: involves: 129S4/SvJae

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Akt2tm1.2Mbb/Akt2tm1.2Mbb,Lepob/Lepob,Tg(Alb1-cre)1Khk/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

Allelic Composition: Akt2tm1.1Mbb/Akt2+,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Akt2tm1.1Mbb

Allelic Composition: Lepob/Lepob,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: B6.Cg-Nfe2l2tm1Mym Lepob

 MP:0009400 decreased skeletal muscle fiber size "decrease in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0009409 abnormal skeletal muscle fiber type ratio "deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0009436 fragmentation of sleep/wake states "short bouts of sleep/wake stages with an increased number of transitions among these stages compared to controls" [PMID:19246384]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0009536 abnormal interstitial cell of Cajal morphology "any structural abnormality in the type of cell found in the gastrointestinal tract and serving as a pacemaker that triggers gut contraction; ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumours (GISTs) arise; abnormalities in the ICC network can cause chronic intestinal pseudo-obstruction" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:16460275]
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Allelic Composition: Kittm1Rosay/Kit+,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Adipoqtm1Ish/Adipoqtm1Ish,Lepob/Lepob
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lep+,Tg(Apoe-Lepr)1Kry/0
Genetic Background: involves: C57BL/6J

Allelic Composition: Lepm1Yst/Lepm1Yst
Genetic Background: C57BL/6J-Lepm1Yst

Allelic Composition: Ccar2tm1Dac/Ccar2tm1Dac,Lepob/Lepob
Genetic Background: involves: 129 * C57BL/6J

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Ldlrtm1Her

Allelic Composition: Ldlrtm1Her/Ldlr+,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Ldlrtm1Her

Allelic Composition: Lepob/Lepob
Genetic Background: involves: C57BL/6

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/JRj

 MP:0010143 enhanced fertility "increased ability to produce live offspring" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
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Allelic Composition: Agrptm2(DTR)Rpa/Agrp+,Lepob/Lepob
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: B6.Cg-Nfe2l2tm1Mym Lepob

 MP:0010379 decreased respiratory quotient "reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Lepob/Lepob,Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cnot3tm1.1Tya/Cnot3+,Lepob/Lepob
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0010400 increased liver glycogen level "greater than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cebpatm1Gonz/Cebpatm1Gonz,Lepob/Lepob,Tg(Alb1-cre)1Dlr/0
Genetic Background: involves: 129X1/SvJ * C57BL/6J * FVB/N

 MP:0010955 abnormal respiratory electron transport chain "anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient" [GO:0022904]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Bsxtm1Tre/Bsxtm1Tre,Lepob/Lepob
Genetic Background: B6.Cg-Lepob Bsxtm1Tre

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

Allelic Composition: Lepob/Lepob,Ucp1tm1Kz/Ucp1tm1Kz
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0011167 abnormal adipose tissue development "anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue" [MESH:A10.165.114, MGI:csmith]
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Allelic Composition: Lepob/Lepob,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: B6.Cg-Nfe2l2tm1Mym Lepob

 MP:0011294 renal glomerulus hypertrophy "increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement" [MGI:anna]
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Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
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Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

 MP:0011430 mesangiolysis "an injurious glomerular process that affects primarily the mesangium, starting with loosening and detachment of its matrix and progressing to dissolution/attenuation with degeneration of mesangial cells; mesangial cells may show only edema and vacuolization, or may undergo severe degeneration and necrosis" [MGI:anna]
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Allelic Composition: Lepob/Lepob
Genetic Background: BTBR.Cg-Lepob/WiscJ

 MP:0011478 abnormal urine catecholamine level "any anomaly in the urinary amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines are act as hormones or neurotransmitters and are derived from the amino acid tyrosine" [MGI:csmith]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Lepob/Lepob,Pmchtm1Emf/Pmchtm1Emf
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob,Tg(Npy-MAPT/Sapphire)1Rck/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lepob/Lepob,Tg(Pomc-MAPT/Topaz)1Rck/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0011940 decreased food intake "reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Lepob/Lepob
Genetic Background: B6.Cg-Lepob/J

Allelic Composition: Lepob/Lepob,Tg(Npy-MAPT/Sapphire)1Rck/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lepob/Lepob,Tg(Pomc-MAPT/Topaz)1Rck/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Lepob/Lepob,Nfe2l2tm1Mym/Nfe2l2tm1Mym
Genetic Background: B6.Cg-Nfe2l2tm1Mym Lepob

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Lepob/Lepob,Ppargtm2Avp/Ppargtm2Avp
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0012706 decreased embryonic neuroepithelial cell proliferation "decrease in the expansion rate of the cells of the embryonic neuroepithelium by cell division" [CL:0000710, MGI:anna]
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Allelic Composition: Lepob/Lepob
Genetic Background: involves: STOCK Mlphln a Tgfawa1 Cdh23v Ednrbs

 MP:0013279 increased fasted circulating glucose level "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0013795 abnormal colon goblet cell morphology "any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the colon, whose primary function is to secrete gel-forming mucins, the major components of mucus" [MGI:Anna, PMID:25872481]
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Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Lepm1Btlr/Lepm1Btlr
Genetic Background: C57BL/6J-Lepm1Btlr

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Lepob/Lepob,Ppargtm1Avp/Pparg+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0014174 decreased fatty acid beta-oxidation "decreased rate or incidence of the process that results in the complete oxidation of a long-chain fatty acid, beginning with the addition of coenzyme A to a fatty acid, with successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)" [GO:0006635]
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Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

 MP:0030021 increased muscle cell glucose uptake "increased ability of muscle cells to take in glucose" [MGI:anna]
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Allelic Composition: Fabp4tm1Brsp/Fabp4tm1Brsp,Fabp5tm1Hota/Fabp5tm1Hota,Lepob/Lepob
Genetic Background: B6.Cg-Fabp4tm1Brsp Fabp5tm1Hota Lepob

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038894 Irs2 / P81122 / Insulin receptor substrate 2 / Q9Y4H2*  / reaction / complex
 ENSMUSG00000057722 Lepr / P48356 / Leptin receptor / P48357*  / complex / reaction
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSMUSG00000030733 Sh2b1 / Q91ZM2 / SH2B adapter protein 1 / Q9NRF2* / SH2B adaptor protein 1*  / reaction / complex
 ENSMUSG00000053113 Socs3 / O35718 / suppressor of cytokine signaling 3 / O14543*  / reaction / complex
 ENSMUSG00000004043 P42230 / Stat5a / signal transducer and activator of transcription 5A / P42229*  / complex / reaction
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex / reaction
 ENSMUSG00000059201 Lep / P41160 / Leptin / P41159*  / reaction / complex
 ENSMUSG00000020919 P42232 / Stat5b / Signal transducer and activator of transcription 5B / P51692*  / reaction / complex






 

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