ENSMUSG00000042594


Mus musculus

Features
Gene ID: ENSMUSG00000042594
  
Biological name :Sh2b3
  
Synonyms : O09039 / Sh2b3 / SH2B adapter protein 3
  
Possible biological names infered from orthology : Q9UQQ2 / SH2B adaptor protein 3
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 121815488
Gene end: 121837646
  
Corresponding Affymetrix probe sets: 10533386 (MoGene1.0st)   1433455_at (Mouse Genome 430 2.0 Array)   1450183_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113808
Ensembl peptide - ENSMUSP00000113926
Ensembl peptide - ENSMUSP00000143505
Ensembl peptide - ENSMUSP00000142666
Ensembl peptide - ENSMUSP00000119086
Ensembl peptide - ENSMUSP00000118523
Ensembl peptide - ENSMUSP00000041611
Ensembl peptide - ENSMUSP00000083490
NCBI entrez gene - 16923     See in Manteia.
MGI - MGI:893598
RefSeq - NM_008507
RefSeq - XM_006530173
RefSeq - XM_006530172
RefSeq - XM_006530171
RefSeq - XM_006530170
RefSeq - NM_001306126
RefSeq - NM_001306127
RefSeq - NM_001306128
RefSeq Peptide - NP_001293055
RefSeq Peptide - NP_001293056
RefSeq Peptide - NP_001293057
RefSeq Peptide - NP_032533
swissprot - D3Z3Y5
swissprot - O09039
swissprot - A0A0G2JE79
swissprot - D6RCY9
swissprot - A0A0G2JGB8
swissprot - D3Z0T9
Ensembl - ENSMUSG00000042594
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sh2b3ENSDARG00000069958Danio rerio
 SH2B3ENSGALG00000004610Gallus gallus
 SH2B3ENSG00000111252Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sh2b1 / Q91ZM2 / SH2B adapter protein 1 / Q9NRF2* / SH2B adaptor protein 1*ENSMUSG0000003073334
Sh2b2 / Q9JID9 / SH2B adaptor protein 2ENSMUSG0000000505732


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR011993  PH-like domain superfamily
 IPR015012  Phenylalanine zipper
 IPR030522  SH2B adapter protein 3
 IPR030523  SH2B adapter protein
 IPR035059  SH2B3, SH2 domain
 IPR036290  Phenylalanine zipper superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035591 signaling adaptor activity IEA


Pathways (from Reactome)
Pathway description
Regulation of KIT signaling
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Juptm1.1Shou/Juptm1.1Shou,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sh2b3tm1Paw/Sh2b3tm1Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sh2b3tm1Paw/Sh2b3tm1Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000240 extramedullary hematopoiesis "formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Sh2b3tm1Paw/Sh2b3tm1Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Juptm1.1Shou/Juptm1.1Shou,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129 * C57BL/6J

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Sh2b3tm1Paw/Sh2b3tm1Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002417 abnormal megakaryocyte morphology/development "anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003135 increased erythrocyte precursors "greater numbers of progenitors of the erythrocyte lineage" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sprtm1Lex/Sprtm1Lex
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sh2b3tm1Paw/Sh2b3tm1Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sh2b3tm1Paw/Sh2b3tm1Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005505 increased platelet count "greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Sh2b3tm1Paw/Sh2b3tm1Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008112 abnormal monocyte differentiation "atypical production of or inability to produce the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood" [CL:0000576, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0008254 increased megakaryocyte cell number "greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sh2b3tm1Paw/Sh2b3tm1Paw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011746 spleen fibrosis "invasion of fibrous connective tissue into the spleen, often resulting from inflammation or injury" [MGI:csmith]
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Allelic Composition: Slc18a2tm1Uhl/Slc18a2tm1Uhl
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005672 Kit / P05532 / Mast/stem cell growth factor receptor Kit / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction






 

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