ENSMUSG00000005057


Mus musculus

Features
Gene ID: ENSMUSG00000005057
  
Biological name :Sh2b2
  
Synonyms : Q9JID9 / Sh2b2 / SH2B adaptor protein 2
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 136218147
Gene end: 136246556
  
Corresponding Affymetrix probe sets: 10534585 (MoGene1.0st)   1450718_at (Mouse Genome 430 2.0 Array)   1453389_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142728
Ensembl peptide - ENSMUSP00000005188
Ensembl peptide - ENSMUSP00000142398
Ensembl peptide - ENSMUSP00000142515
NCBI entrez gene - 23921     See in Manteia.
MGI - MGI:1345171
RefSeq - XM_011240882
RefSeq - NM_001302938
RefSeq - NM_001302939
RefSeq - NM_018825
RefSeq - XM_006504420
RefSeq - XM_006504422
RefSeq Peptide - NP_001289868
RefSeq Peptide - NP_061295
RefSeq Peptide - NP_001289867
swissprot - A0A0G2JED4
swissprot - Q9JID9
swissprot - A0A0G2JDV1
Ensembl - ENSMUSG00000005057
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SH2B2ENSDARG00000090421Danio rerio
 SH2B2ENSGALG00000001828Gallus gallus
 SH2B2ENSG00000160999Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sh2b1 / Q91ZM2 / SH2B adapter protein 1 / Q9NRF2* / SH2B adaptor protein 1*ENSMUSG0000003073340
Sh2b3 / O09039 / SH2B adapter protein 3 / Q9UQQ2* / SH2B adaptor protein 3*ENSMUSG0000004259429


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR015012  Phenylalanine zipper
 IPR030520  SH2B adapter protein 2
 IPR030523  SH2B adapter protein
 IPR035058  SH2B2, SH2 domain
 IPR036290  Phenylalanine zipper superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001922 B-1 B cell homeostasis IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008286 insulin receptor signaling pathway IDA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0019222 regulation of metabolic process IMP
 biological_processGO:0030036 actin cytoskeleton organization IPI
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042593 glucose homeostasis ISA
 biological_processGO:0046325 negative regulation of glucose import ISA
 biological_processGO:0046425 regulation of JAK-STAT cascade IEA
 biological_processGO:0046578 regulation of Ras protein signal transduction IEA
 biological_processGO:0050776 regulation of immune response IMP
 biological_processGO:0050851 antigen receptor-mediated signaling pathway IDA
 biological_processGO:0050873 brown fat cell differentiation IDA
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0001726 ruffle IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005884 actin filament IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity IDA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008269 JAK pathway signal transduction adaptor activity ISO
 molecular_functionGO:0035591 signaling adaptor activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Xu/Trp53tm1Xu
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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