ENSG00000257923


Homo sapiens

Features
Gene ID: ENSG00000257923
  
Biological name :CUX1
  
Synonyms : cut like homeobox 1 / CUX1 / P39880 / Q13948
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q22.1
Gene start: 101815904
Gene end: 102283958
  
Corresponding Affymetrix probe sets: 202367_at (Human Genome U133 Plus 2.0 Array)   214743_at (Human Genome U133 Plus 2.0 Array)   225935_at (Human Genome U133 Plus 2.0 Array)   225937_at (Human Genome U133 Plus 2.0 Array)   227069_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000496739
Ensembl peptide - ENSP00000292535
Ensembl peptide - ENSP00000292538
Ensembl peptide - ENSP00000353401
Ensembl peptide - ENSP00000377410
Ensembl peptide - ENSP00000409745
Ensembl peptide - ENSP00000414091
Ensembl peptide - ENSP00000494610
Ensembl peptide - ENSP00000496653
Ensembl peptide - ENSP00000446630
Ensembl peptide - ENSP00000447373
Ensembl peptide - ENSP00000449371
Ensembl peptide - ENSP00000450125
Ensembl peptide - ENSP00000451558
Ensembl peptide - ENSP00000484760
NCBI entrez gene - 1523     See in Manteia.
OMIM - 116896
RefSeq - XM_017011760
RefSeq - NM_001202543
RefSeq - NM_001202544
RefSeq - NM_001202545
RefSeq - NM_001202546
RefSeq - NM_001913
RefSeq - NM_181500
RefSeq - NM_181552
RefSeq - XM_005250150
RefSeq - XM_005250151
RefSeq - XM_005250154
RefSeq - XM_006715854
RefSeq - XM_006715855
RefSeq - XM_011515823
RefSeq - XM_011515825
RefSeq - XM_017011759
RefSeq Peptide - NP_001189472
RefSeq Peptide - NP_001189473
RefSeq Peptide - NP_001189474
RefSeq Peptide - NP_001189475
RefSeq Peptide - NP_001904
RefSeq Peptide - NP_852477
RefSeq Peptide - NP_853530
swissprot - P39880
swissprot - Q13948
Ensembl - ENSG00000257923
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Cux1ENSMUSG00000029705Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CUX2 / O14529 / cut like homeobox 2ENSG0000011124945
O95948 / ONECUT2 / one cut homeobox 2ENSG000001195478
Q9UBC0 / ONECUT1 / one cut homeobox 1ENSG000001698568
O60422 / ONECUT3 / one cut homeobox 3ENSG000002059227


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003350  CUT domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR012955  CASP, C-terminal
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II TAS
 biological_processGO:0000301 retrograde transport, vesicle recycling within Golgi IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006891 intra-Golgi vesicle-mediated transport IEA
 biological_processGO:0007275 multicellular organism development TAS
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0048193 Golgi vesicle transport IBA
 biological_processGO:0050775 positive regulation of dendrite morphogenesis ISS
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030173 integral component of Golgi membrane IEA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
Signaling by cytosolic FGFR1 fusion mutants
Signaling by FGFR1 in disease
Intra-Golgi traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000106636 YKT6 / O15498 / YKT6 v-SNARE homolog  / reaction
 ENSG00000162236 STX5 / Q13190 / syntaxin 5  / reaction
 ENSG00000173757 P51692 / STAT5B / signal transducer and activator of transcription 5B  / reaction
 ENSG00000108587 GOSR1 / O95249 / golgi SNAP receptor complex member 1  / reaction
 ENSG00000126561 P42229 / STAT5A / signal transducer and activator of transcription 5A  / reaction
 ENSG00000066455 GOLGA5 / Q8TBA6 / golgin A5  / reaction
 ENSG00000257923 CUX1 / P39880 / Q13948 / cut like homeobox 1  / complex
 ENSG00000173905 GOLIM4 / O00461 / golgi integral membrane protein 4  / reaction
 ENSG00000177951 BET1L / Q9NYM9 / Bet1 golgi vesicular membrane trafficking protein like  / reaction






 

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© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr