ENSG00000111249


Homo sapiens

Features
Gene ID: ENSG00000111249
  
Biological name :CUX2
  
Synonyms : cut like homeobox 2 / CUX2 / O14529
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.11
Gene start: 111034024
Gene end: 111350554
  
Corresponding Affymetrix probe sets: 1566528_at (Human Genome U133 Plus 2.0 Array)   213920_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261726
Ensembl peptide - ENSP00000380765
NCBI entrez gene - 23316     See in Manteia.
OMIM - 610648
RefSeq - XM_017019081
RefSeq - NM_015267
RefSeq - XM_011538069
RefSeq - XM_011538070
RefSeq - XM_017019080
RefSeq - XM_011538061
RefSeq - XM_011538063
RefSeq Peptide - NP_056082
swissprot - O14529
swissprot - F5GWR6
Ensembl - ENSG00000111249
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cux2bENSDARG00000086345Danio rerio
 CUX2ENSGALG00000004598Gallus gallus
 Cux2ENSMUSG00000042589Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CUX1 / P39880 / Q13948 / cut like homeobox 1ENSG0000025792345
Q9UBC0 / ONECUT1 / one cut homeobox 1ENSG000001698568
O60422 / ONECUT3 / one cut homeobox 3ENSG000002059228
O95948 / ONECUT2 / one cut homeobox 2ENSG000001195477


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003350  CUT domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR017970  Homeobox, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0007614 short-term memory IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0048193 Golgi vesicle transport IBA
 biological_processGO:0050775 positive regulation of dendrite morphogenesis IEA
 biological_processGO:0050890 cognition IMP
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IEA
 biological_processGO:0071310 cellular response to organic substance IEA
 biological_processGO:2000463 positive regulation of excitatory postsynaptic potential IEA
 cellular_componentGO:0000139 Golgi membrane IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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