MP:0000367 | abnormal coat/ hair morphology | "anomalous color, structure, growth, or texture of the hair" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: C3H/He
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MP:0000377 | abnormal hair follicle | "malformed invagination of the epidermis from which the hair shaft develops" [J:65031] |
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: OF1
Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0000381 | enlarged hair follicles | "increased size of the epidermal invaginations from which the hair shaft develops" [J:30249] |
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb Genetic Background: involves: BALB/c
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MP:0000383 | abnormal hair follicle orientation | "misaligned hair follicles; hair follicles that do not orient in a typical pattern" [J:47620] |
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: OF1
Allelic Composition: Cux1tm1Ejn/Cux1tm1Ejn Genetic Background: involves: 129S4/SvJae * C57BL
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MP:0000388 | absent inner root sheath | "missing epidermally derived layer surrounding the hair follicle; innermost of two layers" [J:65047] |
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: OF1
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MP:0000414 | alopecia | "absence of hair or loss of hair; not usually in reference to primary genetic hairlessness but may be due to dietary, stress, secondary to immune condition" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:30772, J:33796] |
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb Genetic Background: involves: BALB/c
Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0000416 | sparse fur | "fur that is significantly less dense" [J:46854] |
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: OF1
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MP:0000706 | small thymus | "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167] |
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Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0000711 | thymic cortex hypoplasia | "reduced cell number in the outer portion of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0000715 | decreased thymocyte number | "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0001175 | abnormal lung morphology | "malformed organ of respiration" [J:35802] |
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0001176 | abnormal lung development | "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931] |
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Ptger3tm1Sna/Ptger3tm1Sna Genetic Background: B6.129P2-Ptger3tm1Sna
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MP:0001274 | curly vibrissae | "whiskers twisted into coils or spirals" [J:47620] |
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: OF1
Allelic Composition: Cux1tm1Ejn/Cux1tm1Ejn Genetic Background: involves: 129S4/SvJae * C57BL
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MP:0001278 | kinked vibrissae | "sharp bends in the vibrissae" [J:56641] |
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Allelic Composition: Cux1tm1Ejn/Cux1tm1Ejn Genetic Background: involves: 129S4/SvJae * C57BL
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MP:0001279 | wavy vibrissae | "whiskers having undulations or a sinusoidal shape" [J:65044] |
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Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0001282 | short vibrissae | "decreased length of the vibrissae" [J:30249] |
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Allelic Composition: Ppargtm1Yec/Ppargtm1Yec Genetic Background: involves: 129S4/SvJae * C57BL/6
Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: OF1
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MP:0001575 | cyanosis | "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159] |
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0001601 | abnormal myelopoiesis | "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc] |
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Allelic Composition: Ptger3tm1Sna/Ptger3tm1Sna Genetic Background: B6.129P2-Ptger3tm1Sna
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb Genetic Background: involves: BALB/c
Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: OF1
Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0001823 | thymus hypoplasia | "small size due to reduced cell number in the thymus" [J:23255] |
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Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0001867 | rhinitis | "inflammation of the mucous membrane of the nose" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896] |
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb Genetic Background: involves: BALB/c
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MP:0001921 | reduced fertility | "diminished ability to produce live offspring" [J:65030] |
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Allelic Composition: Cux1tm1Ejn/Cux1tm1Ejn Genetic Background: C.129S4-Cux1tm1Ejn
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MP:0001922 | reduced male fertility | "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340] |
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb Genetic Background: involves: BALB/c
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MP:0001953 | respiratory failure | "cessation of or failure to commence breathing" [MGI:cls, J:60159] |
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb Genetic Background: involves: BALB/c
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ptger3tm1Sna/Ptger3tm1Sna Genetic Background: B6.129P2-Ptger3tm1Sna
Allelic Composition: Cux1tm1Ejn/Cux1tm1Ejn Genetic Background: C.129S4-Cux1tm1Ejn
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MP:0002145 | abnormal T lymphocyte development | "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0002271 | abnormal alveolar duct morphology | "any structural anomaly of the conducting tubes leading to the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002324 | abnormal blood-air barrier | "anomaly in the membrane between the capillary blood and alveolar air, comprised of the alveolar epithelium and the capillary epithelium and their adherent basement membranes and epithelial cell cytoplasm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0002412 | increased susceptibility to bacterial infection | "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb Genetic Background: involves: BALB/c
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MP:0002780 | decreased circulating testosterone level | "less than the normal blood concentration of this most potent androgen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Il4ratm1Fbb/Il4ratm1Fbb Genetic Background: involves: BALB/c
Allelic Composition: Cux1tm2Ejn/Cux1+ Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0003068 | enlarged kidney | "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator] |
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Allelic Composition: Cux1tm1Ejn/Cux1tm1Ejn,Cys1cpk/Cys1cpk Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0003675 | kidney cysts | "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Cux1tm1Ejn/Cux1tm1Ejn,Cys1cpk/Cys1cpk Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0003795 | abnormal bone structure | |
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Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0003809 | abnormal hair shaft morphology | "irregular or unusual structure of the cuticle, and/or cortex and/or medulla of a hair" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
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MP:0003917 | increased kidney weight | "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission] |
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Allelic Composition: Cux1tm1Ejn/Cux1tm1Ejn,Cys1cpk/Cys1cpk Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0005017 | decreased B cell number | "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0005092 | decreased double-positive T cell count | "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0005150 | cachexia | "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0005409 | darkened coat color | "amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreasesd when compared to wild-type agouti" [llw2:Linda Washburn , Mouse Genome Informatics Curator] |
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Allelic Composition: Cux1tm1Ejn/Cux1tm1Ejn Genetic Background: involves: 129S4/SvJae * C57BL
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MP:0005565 | increased blood urea nitrogen level | "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Cux1tm1Ejn/Cux1tm1Ejn,Cys1cpk/Cys1cpk Genetic Background: involves: 129S4/SvJae * C57BL/6
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MP:0006363 | absent auchene hairs | "absence of truncal hairs having a single constriction and bend about midway along the hair shaft, and contain two or more air cells in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: OF1
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MP:0006364 | absent awl hair | "absence of truncal hairs that are straight, but are shorter than guard hairs, and contain two or more air cells in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: OF1
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MP:0006365 | absent guard hair | "absence of the long, straight truncal hairs that contain two air cells in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: OF1
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MP:0006366 | absent zigzag hairs | "absence of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla" [ISBN:0-8493-8372-2 "Sundberg, JP (ed.) Handbook of Mouse Mutations with Skin and Hair Abnormalities", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: OF1
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MP:0008752 | abnormal tumor necrosis factor level | "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800] |
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Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0008779 | abnormal maternal behavior | "any response from the mother inconsistent with ability of young to thrive" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cux1tm1Ejn/Cux1tm1Ejn Genetic Background: involves: 129S4/SvJae * C57BL
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MP:0008947 | increased neuron number | "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663] |
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Allelic Composition: Stat3tm1Dlv/Stat3tm1Dlv,Tg(Csf1r-icre)1Jwp/0 Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB
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MP:0010025 | decreased total body fat amount | "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Cux1tm1Ejn/Cux1tm1Ejn Genetic Background: C.129S4-Cux1tm1Ejn
Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn Genetic Background: C.129S4-Cux1tm2Ejn
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MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: 129P2/OlaHsd * C57BL/6
Allelic Composition: Cux1tm1Mbu/Cux1tm1Mbu Genetic Background: involves: C3H/He
Allelic Composition: Cux1tm1Rhsc/Cux1tm1Rhsc Genetic Background: involves: 129S1/Sv * C57BL/6J
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MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Cux1tm2Ejn/Cux1tm2Ejn,Cux2tm1.1Nieto/Cux2tm1.1Nieto Genetic Background: involves: 129S4/SvJae * C57BL6 * FVB/N * Swiss Webster
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