ENSMUSG00000045518


Mus musculus

Features
Gene ID: ENSMUSG00000045518
  
Biological name :Onecut3
  
Synonyms : Onecut3 / One cut domain family member 3 / Q8K557
  
Possible biological names infered from orthology : O60422 / one cut homeobox 3
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 80494835
Gene end: 80517276
  
Corresponding Affymetrix probe sets: 10364810 (MoGene1.0st)   1428040_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000053288
NCBI entrez gene - 246086     See in Manteia.
MGI - MGI:1891409
RefSeq - NM_139226
RefSeq Peptide - NP_631972
swissprot - Q8K557
Ensembl - ENSMUSG00000045518
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 onecut3aENSDARG00000056395Danio rerio
 onecut3bENSDARG00000091059Danio rerio
 ONECUT3ENSGALG00000028081Gallus gallus
 O60422ENSG00000205922Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6XBJ3 / Onecut2 / One cut domain family member 2 / O95948* / one cut homeobox 2*ENSMUSG0000004599154
O08755 / Onecut1 / one cut domain, family member 1 / Q9UBC0* / one cut homeobox 1*ENSMUSG0000004301353
Cux1 / cut-like homeobox 1 / P39880* / Q13948*ENSMUSG0000002970522
Cux2 / P70298 / Homeobox protein cut-like 2 / O14529* / cut like homeobox 2*ENSMUSG0000004258921


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003350  CUT domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048731 system development IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005667 transcription factor complex IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem,Onecut3tm1Jqmn/Onecut3tm1Jqmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem,Onecut3tm1Jqmn/Onecut3tm1Jqmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0009111 pancreas hypoplasia "underdevelopment or reduced size of the pancreas, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem,Onecut3tm1Jqmn/Onecut3tm1Jqmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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