ENSMUSG00000043013


Mus musculus

Features
Gene ID: ENSMUSG00000043013
  
Biological name :Onecut1
  
Synonyms : O08755 / Onecut1 / one cut domain, family member 1
  
Possible biological names infered from orthology : one cut homeobox 1 / Q9UBC0
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: D
Gene start: 74861921
Gene end: 74891781
  
Corresponding Affymetrix probe sets: 10587082 (MoGene1.0st)   1421447_at (Mouse Genome 430 2.0 Array)   1450252_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000058020
NCBI entrez gene - 15379     See in Manteia.
MGI - MGI:1196423
RefSeq - NM_008262
RefSeq Peptide - NP_032288
swissprot - O08755
Ensembl - ENSMUSG00000043013
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ONECUT1ENSGALG00000038618Gallus gallus
 Q9UBC0ENSG00000169856Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6XBJ3 / Onecut2 / One cut domain family member 2 / O95948* / one cut homeobox 2*ENSMUSG0000004599167
Q8K557 / Onecut3 / One cut domain family member 3 / O60422* / one cut homeobox 3*ENSMUSG0000004551856
Cux1 / cut-like homeobox 1 / P39880* / Q13948*ENSMUSG0000002970525
Cux2 / P70298 / Homeobox protein cut-like 2 / O14529* / cut like homeobox 2*ENSMUSG0000004258922


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR003350  CUT domain
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IGI
 biological_processGO:0001952 regulation of cell-matrix adhesion IGI
 biological_processGO:0002064 epithelial cell development IMP
 biological_processGO:0006006 glucose metabolic process IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IMP
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0009653 anatomical structure morphogenesis IMP
 biological_processGO:0030154 cell differentiation IMP
 biological_processGO:0030183 B cell differentiation IMP
 biological_processGO:0030335 positive regulation of cell migration IGI
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IGI
 biological_processGO:0031016 pancreas development IMP
 biological_processGO:0031018 endocrine pancreas development TAS
 biological_processGO:0045165 cell fate commitment IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048536 spleen development IMP
 biological_processGO:0060271 cilium assembly IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm TAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IBA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Rhotm1Phm/Rhotm1Phm
Genetic Background: B6.129S1-Rhotm1Phm

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rhotm1Phm/Rhotm1Phm
Genetic Background: B6.129S1-Rhotm1Phm

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem,Onecut3tm1Jqmn/Onecut3tm1Jqmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rhotm1Phm/Rhotm1Phm
Genetic Background: B6.129S1-Rhotm1Phm

 MP:0002693 abnormal pancreas physiology "abberrant function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0002696 decreased circulating glucagon level "lower than normal blood concentration of this peptide hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002929 abnormal bile duct development "incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003250 absent gall bladder "absence of the organ which serves as a storage reservoir for bile" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003266 biliary cysts "the appearance of fluid-filled sacs within the bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003334 pancreatic fibrosis "invasion of fibrous connective tissue into the pancreas, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0003336 pancreatic cysts "the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0003934 abnormal pancreas development "anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem,Onecut2tm1Flem/Onecut2tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem,Onecut3tm1Jqmn/Onecut3tm1Jqmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005083 abnormal biliary tract morphology "anomalous structure or development of the gall bladder or its ducts " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009111 pancreas hypoplasia "underdevelopment or reduced size of the pancreas, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem,Onecut3tm1Jqmn/Onecut3tm1Jqmn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0009143 abnormal pancreatic duct morphology "any structural anomaly of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0009144 dilated pancreatic duct "an increase in volume of the luminal space of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A03.734.667]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0009145 abnormal pancreatic acinus morphology "any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0009149 decreased pancreatic acinar cell number "reduced number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0009164 exocrine pancreas atrophy "wasting of the acinar gland portion of the pancreas that secretes digestive enzymes resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0009173 absent pancreatic islets "absence of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0009174 absent pancreatic beta cells "absence of the cells of the pancreas that secrete insulin" [MESH:A03.734.414.131]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009177 decreased pancreatic alpha cell number "reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0009178 absent pancreatic alpha cells "absence of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009181 decreased pancreatic delta cell number "reduced number of the cells found in the pancreas that secrete somatostatin" [MESH:A03.556.875.875.440.854]
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Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009254 disorganized pancreatic islets "derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011932 abnormal endocrine pancreas development 
Show

Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011934 abnormal branching involved in pancreas development "any anomaly in the process in which the branches of the developing pancreas are generated and organized" [GO:0061114]
Show

Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0012242 abnormal hepatoblast differentiation "developmental anomaly or inability of hepatoblasts to differentiate into hepatocytes and cholangiocytes" [MGI:anna]
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Allelic Composition: Nectin2tm1Vrr/Nectin2tm1Vrr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem,Onecut2tm1Flem/Onecut2tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0012246 abnormal hepatic cord morphology "any structural anomaly of the three-dimensional arrangement formed by plates of hepatocytes, usually one cell thick, that radiates from the center of the liver lobule; hepatic laminae are highly branched, irregular structures bordered by endothelial lined vascular spaces called hepatic sinusoids" [MGI:anna]
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Allelic Composition: Onecut1tm1Flem/Onecut1tm1Flem,Onecut2tm1Flem/Onecut2tm1Flem
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Swiss

 MP:0013221 pancreatic acinar-to-ductal metaplasia "a reprogramming event that induces transdifferentiation of pancreatic acinar cells to a duct-like phenotype in response to inflammatory injury; ADM is associated with an increased risk of exocrine pancreatic cancer and is considered a precursor of pancreatic ductal adenocarcinoma" [MGI:anna]
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Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

 MP:0014108 calcified pancreas "pathologic deposition of calcium salts in the pancreas; commonly seen in chronic pancreatitis" [MGI:Anna]
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Allelic Composition: Onecut1tm1.1Mga/Onecut1tm1.1Mga,Tg(Pdx1-cre)89.1Dam/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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