3667


Homo sapiens (NCBI)

Features
Gene ID: 3667
  
Biological name :
  
Synonyms : HIRS-1 / insulin receptor substrate 1 / IRS1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens (NCBI)
  
Chr. number:
Strand:
Band:
Gene start:
Gene end:
  
Corresponding Affymetrix probe sets: 204686_at (Human Genome U133 Plus 2.0 Array)   238933_at (Human Genome U133 Plus 2.0 Array)   242979_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: RefSeq - 5031805
RefSeq - NC_000002.12
RefSeq - NG_015830.1
RefSeq - NP_005535.1
RefSeq - NM_005544.2
  
See co-cited genes in PubMed
Warning: Please see the Ensembl gene model ENSG00000169047 to get all the annotations available for this gene.


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0008284 positive regulation of cell proliferation NAS
 biological_processGO:0008286 insulin receptor signaling pathway IPI
 biological_processGO:0010907 positive regulation of glucose metabolic process IMP
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IDA
 biological_processGO:0019216 regulation of lipid metabolic process IBA
 biological_processGO:0032000 positive regulation of fatty acid beta-oxidation IMP
 biological_processGO:0032868 response to insulin IDA
 biological_processGO:0032869 cellular response to insulin stimulus IMP
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0038111 interleukin-7-mediated signaling pathway TAS
 biological_processGO:0042593 glucose homeostasis TAS
 biological_processGO:0043434 response to peptide hormone ISS
 biological_processGO:0043552 positive regulation of phosphatidylinositol 3-kinase activity ISS
 biological_processGO:0045725 positive regulation of glycogen biosynthetic process NAS
 biological_processGO:0046326 positive regulation of glucose import IMP
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway ISS
 biological_processGO:0046628 positive regulation of insulin receptor signaling pathway ISS
 biological_processGO:0046676 negative regulation of insulin secretion IDA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IEA
 biological_processGO:0048009 insulin-like growth factor receptor signaling pathway IPI
 biological_processGO:0048015 phosphatidylinositol-mediated signaling TAS
 biological_processGO:0051897 positive regulation of protein kinase B signaling TAS
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IDA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005899 insulin receptor complex ISS
 cellular_componentGO:0005901 caveola IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISS
 molecular_functionGO:0001784 phosphotyrosine residue binding IPI
 molecular_functionGO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity ISS
 molecular_functionGO:0005080 protein kinase C binding ISS
 molecular_functionGO:0005088 Ras guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005158 insulin receptor binding IPI
 molecular_functionGO:0005159 insulin-like growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0042169 SH2 domain binding ISS
 molecular_functionGO:0043548 phosphatidylinositol 3-kinase binding ISS
 molecular_functionGO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS


Pathways (from Reactome)
Pathway description
No match


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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