ENSMUSG00000060538


Mus musculus

Features
Gene ID: ENSMUSG00000060538
  
Biological name :Tmem219
  
Synonyms : Q9D123 / Tmem219 / transmembrane protein 219
  
Possible biological names infered from orthology : Q86XT9
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 126886171
Gene end: 126922917
  
Corresponding Affymetrix probe sets: 10568099 (MoGene1.0st)   1424497_at (Mouse Genome 430 2.0 Array)   1430505_at (Mouse Genome 430 2.0 Array)   1457243_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116806
Ensembl peptide - ENSMUSP00000115017
Ensembl peptide - ENSMUSP00000135259
Ensembl peptide - ENSMUSP00000032926
Ensembl peptide - ENSMUSP00000112485
Ensembl peptide - ENSMUSP00000113260
Ensembl peptide - ENSMUSP00000113647
Ensembl peptide - ENSMUSP00000114040
NCBI entrez gene - 68742     See in Manteia.
MGI - MGI:1915992
RefSeq - XM_006508158
RefSeq - NM_026827
RefSeq - NM_028389
RefSeq - XM_006508155
RefSeq - XM_006508156
RefSeq - XM_006508157
RefSeq Peptide - NP_082665
RefSeq Peptide - NP_081103
swissprot - F6VVM1
swissprot - G3X9Z3
swissprot - G5E8V1
swissprot - H3BK56
swissprot - Q9D123
swissprot - D3Z6H6
swissprot - D3Z3J3
Ensembl - ENSMUSG00000060538
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q86XT9ENSG00000149932Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
No match


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
TP53 Regulates Transcription of Death Receptors and Ligands


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0008837 increased transforming growth factor level "greater concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
Show

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0008838 decreased transforming growth factor level "reduced concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function" [MESH:D12.644.276.374.687]
Show

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0020344 abnormal susceptibility to injury induced morbidity/mortality "differences from the expected moribund state caused by trauma, especially that by physical means" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

 MP:0030002 increased lung apoptosis "acceleration in the timing or in the number of cells of the lung undergoing programmed cell death" [ORCID:orcid.org/0000-0002-6490-7723, PMID:17589521]
Show

Allelic Composition: Apptm1.1Wevn/Apptm1.1Wevn
Genetic Background: B6.129S6(FVB)-Apptm1.1Wevn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020427 Igfbp3 / P47878 / Insulin-like growth factor-binding protein 3 / P17936*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr