ENSDARG00000062707


Danio rerio

Features
Gene ID: ENSDARG00000062707
  
Biological name :plat
  
Synonyms : plasminogen activator, tissue / plat
  
Possible biological names infered from orthology : P00750 / P11214 / plasminogen activator, tissue type / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plasminogen activator chain B
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 2260912
Gene end: 2306477
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000120778
Ensembl peptide - ENSDARP00000145513
NCBI entrez gene - 100320028     See in Manteia.
swissprot - F1QB78
ZFIN ID - ZDB-GENE-081104-181
Ensembl - ENSDARG00000062707
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PLATENSGALG00000003709Gallus gallus
 PLATENSG00000104368Homo sapiens
 PlatENSMUSG00000031538Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
plaub / plasminogen activator, urokinase b / PLAU* / P00749* / P06869* / plasminogen activator, urokinase*ENSDARG0000003914529
habp2 / hyaluronan binding protein 2 / Q14520* / Mus musculus hyaluronic acid binding protein 2 (Habp2), transcript variant 1, mRNA.*ENSDARG0000005749829
plg / plasminogen / LPA* / P08519* / P20918* / P00747* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*ENSDARG0000002311128
plaua / plasminogen activator, urokinase a / PLAU* / P00749* / P06869* / plasminogen activator, urokinase*ENSDARG0000007526525
f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*ENSDARG0000003604120
mst1 / macrophage stimulating 1 / P26928* / macrophage stimulating 1 (hepatocyte growth factor-like)*ENSDARG0000010330819
hgfa / hepatocyte growth factor a / HGF* / P14210* / Q08048* / hepatocyte growth factor* / Hepatocyte growth factor Hepatocyte growth factor alpha chain Hepatocyte growth factor beta chain*ENSDARG0000004554418
hgfb / hepatocyte growth factor b / HGF* / P14210* / hepatocyte growth factor*ENSDARG0000007907617


Protein motifs (from Interpro)
Interpro ID Name
 IPR000001  Kringle
 IPR000742  EGF-like domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR013032  EGF-like, conserved site
 IPR013806  Kringle-like fold
 IPR018056  Kringle, conserved site
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR026280  Tissue plasminogen activator
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR034811  Tissue-type plasminogen activator


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0031639 plasminogen activation IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Signaling by PDGF
Dissolution of Fibrin Clot


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000023111 plg / plasminogen / LPA* / P08519* / P20918* / P00747* / lipoprotein(a)* / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B*  / reaction / complex
 ENSDARG00000056795 serpine1 / serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 / P05121* / serpin family E member 1* / serine (or cysteine) peptidase inhibitor, cl...  / complex / reaction
 ENSDARG00000077588 pdgfc / platelet derived growth factor c / Q8CI19* / Q9NRA1* / platelet-derived growth factor, C polypeptide*  / reaction
 ENSDARG00000062707 plat / plasminogen activator, tissue / P11214* / P00750* / plasminogen activator, tissue type* / Tissue-type plasminogen activator Tissue-type plasminogen activator chain A Tissue-type plas...  / complex






 

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