ENSDARG00000042684


Danio rerio

Features
Gene ID: ENSDARG00000042684
  
Biological name :serpinc1
  
Synonyms : serpinc1 / serpin peptidase inhibitor, clade C (antithrombin), member 1
  
Possible biological names infered from orthology : P01008 / P32261 / serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 / serpin family C member 1
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 16022211
Gene end: 16028191
  
Corresponding Affymetrix probe sets: Dr.4199.1.S1_at (Zebrafish Array)   NM_182863_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000062617
NCBI entrez gene - 321545     See in Manteia.
RefSeq - NM_182863
RefSeq Peptide - NP_878283
swissprot - Q8AYE3
ZFIN ID - ZDB-GENE-030131-264
Ensembl - ENSDARG00000042684
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SERPINC1ENSGALG00000004591Gallus gallus
 P01008ENSG00000117601Homo sapiens
 P32261ENSMUSG00000026715Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
serpini1 / serpin peptidase inhibitor, clade I (neuroserpin), member 1 / O35684* / Q99574* / serpin family I member 1* / serine (or cysteine) peptidase inhibitor, clade I, member 1*ENSDARG0000003416825
serpine1 / serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 / P05121* / serpin family E member 1* / serine (or cysteine) peptidase inhibitor, cl...ENSDARG0000005679523
serpine2 / serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 / P07093* / serpin family E member 2*ENSDARG0000002935323
B0UYL8 / serpine3 / serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 / A8MV23* / serpin family E member 3*ENSDARG0000005710822
serpinh1a / serpin peptidase inhibitor, clade H (heat shock protein 47), member 1a / P50454* / P19324* / SERPINH1* / Serpin H1 * / serpin family H member 1*ENSDARG0000007595421
serpinh1b / serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b / P50454* / P19324* / SERPINH1* / Serpin H1 * / serpin family H member 1*ENSDARG0000001994921
serpinh2 / serine (or cysteine) peptidase inhibitor, clade H, member 2ENSDARG0000003644518


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR015555  Antithrombin-III
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR033829  Antithrombin serpin domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030193 regulation of blood coagulation IMP
 biological_processGO:0071391 cellular response to estrogen stimulus IDA
 biological_processGO:2000266 regulation of blood coagulation, intrinsic pathway IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IBA
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000114 heart heart obstructed , abnormal
heart blood coagulation increased process quality , abnormal
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 ZFA:0000477 posterior cardinal vein posterior cardinal vein blood coagulation, fibrin clot formation delayed , abnormal
posterior cardinal vein blood coagulation, fibrin clot formation increased occurrence , abnormal
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 ZFA:0001094 whole organism whole organism decreased life span , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000036041 f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / complex / reaction
 ENSDARG00000042684 serpinc1 / serpin peptidase inhibitor, clade C (antithrombin), member 1 / P01008* / P32261* / serpin family C member 1* / serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1*  / complex






 

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