ENSMUSG00000026715


Mus musculus

Features
Gene ID: ENSMUSG00000026715
  
Biological name :Serpinc1
  
Synonyms : P32261 / serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 / Serpinc1
  
Possible biological names infered from orthology : P01008 / serpin family C member 1
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H2.1
Gene start: 160978585
Gene end: 161005863
  
Corresponding Affymetrix probe sets: 10351015 (MoGene1.0st)   1417909_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068971
Ensembl peptide - ENSMUSP00000142122
Ensembl peptide - ENSMUSP00000141885
Ensembl peptide - ENSMUSP00000141864
Ensembl peptide - ENSMUSP00000141834
Ensembl peptide - ENSMUSP00000141556
NCBI entrez gene - 11905     See in Manteia.
MGI - MGI:88095
RefSeq - XM_006496626
RefSeq - NM_080844
RefSeq Peptide - NP_543120
swissprot - A0A0A6YWH7
swissprot - A0A0A6YX85
swissprot - A0A0A6YXS8
swissprot - P32261
swissprot - Q543J5
swissprot - A0A0A6YX49
swissprot - A0A0A6YX70
Ensembl - ENSMUSG00000026715
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 serpinc1ENSDARG00000042684Danio rerio
 SERPINC1ENSGALG00000004591Gallus gallus
 P01008ENSG00000117601Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9D7P9 / Serpinb12 / Serpin B12 / Q96P63* / serpin family B member 12*ENSMUSG0000005995629
Q9CQV3 / Serpinb11 / Serpin B11 / Q96P15* / serpin family B member 11 (gene/pseudogene)*ENSMUSG0000002632729
O35684 / Serpini1 / serine (or cysteine) peptidase inhibitor, clade I, member 1 / Q99574* / serpin family I member 1*ENSMUSG0000002783428
Q9D695 / Serpinb7 / Serpin B7 / O75635* / serpin family B member 7*ENSMUSG0000006700127
Q9JK88 / Serpini2 / serine (or cysteine) peptidase inhibitor, clade I, member 2 / O75830* / serpin family I member 2*ENSMUSG0000003413927
Q07235 / Serpine2 / serine (or cysteine) peptidase inhibitor, clade E, member 2 / P07093* / serpin family E member 2*ENSMUSG0000002624925
Serpine1 / serine (or cysteine) peptidase inhibitor, clade E, member 1 / P05121* / serpin family E member 1*ENSMUSG0000003741124
Serpine3 / serpin family E member 3 / A8MV23*ENSMUSG0000009115523
P19324 / Serpinh1 / Serpin H1 / P50454* / serpin family H member 1*ENSMUSG0000007043620


Protein motifs (from Interpro)
Interpro ID Name
 IPR000215  Serpin family
 IPR015555  Antithrombin-III
 IPR023795  Serpin, conserved site
 IPR023796  Serpin domain
 IPR033829  Antithrombin serpin domain
 IPR036186  Serpin superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002438 acute inflammatory response to antigenic stimulus IEA
 biological_processGO:0007584 response to nutrient IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0007596 blood coagulation IEA
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0030193 regulation of blood coagulation IEA
 biological_processGO:2000266 regulation of blood coagulation, intrinsic pathway IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11+
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11+
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn
Genetic Background: involves: 129P2/OlaHsd

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11+
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002658 abnormal liver regeneration "deviation from the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002698 abnormal sclera morphology "structural anomaly of the fibrous, outer envelope of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002847 abnormal glomerular filtration rate "deviation from the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Serpinc1tm1Sai/Serpinc1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11+
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0003328 portal hypertension "elevation of arterial blood pressure in the hepatic portal system, often a result of cirrhosis or of blockage of the portal vein" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003415 priapism "prolonged penile erection, often painful and without sexual desire " [smb:Susan M Bello, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005048 thrombosis "formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11+
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Serpinc1tm1Sai/Serpinc1+
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005098 abnormal choroid morphology "anomalous structure of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005187 abnormal penis morphology "anomalous structure of the organ of copulation and urination in the male" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11+
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0006137 venoocclusion "blockage of blood flow through one or more veins" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Serpinc1tm1Dwr/Serpinc1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Hoxa11tm1Ssp/Hoxa11+
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Atp1a1Gt(OST31117)Lex/Atp1a1Gt(OST31117)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0020407 abnormal placental thrombosis "any anomaly in the formation or presence of a thrombus within the blood vessel network of the placenta" [MGI:anna]
Show

Allelic Composition: Serpinc1tm1Dwr/Serpinc1tm1Dwr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / complex / reaction
 ENSMUSG00000026715 P32261 / Serpinc1 / serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1 / P01008* / serpin family C member 1*  / complex






 

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